cryopreservation Articles
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Cryopreservation Process, Methods and Storage Solution Explored
The Cryopreservation Process The Cryopreservation Process is where biological matter (cells, tissue, organs, etc) is preserved by cooling to a very low temperature. This process stops the normal cell functions and holds the sample in suspended animation. When the time comes to thaw the sample, normal biological function resumes.Cryopreservation Process Steps The cryopreservation process can be ...
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Pooled Human Cryopreserved Hepatocytes
Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since these cells mimic the properties of the liver, researchers can evaluate the ...
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IVF Cryopreservation and Safe Handling Practices
Couples that want to have a baby but have not been able to conceive naturally are drawn to invitro fertilization (IVF) treatments. In an IVF treatment, several eggs are fertilized at once, which creates multiple embryos. While more than one embryo may be implanted, to spur the odds of pregnancy, there are inevitably some unused embryos. The remaining embryos may be preserved cryogenically, for ...
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Biorepository Safety
What is a Biorepository? A biorepository, or "biobank", is a specialized facility designed to store, archive, and distribute biological samples for research or clinical purposes. Biorepositories house biological samples, such as blood, plasma, urine, saliva, tissues, DNA, and organs, among other specimen types, collected from consenting individuals. Critical associated information, including ...
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Q&A with Flyn McKinnirey, R&D Manager at Regeneus
Q. What is your background and experience in the regenerative medicine and stem cell space? How did this lead you to Regeneus? A. I’d always had a love for medical research, however found myself working in the pharmaceutical industry after university prior to joining Regeneus. After 6 years in the pharma industry, I’d decided I needed to get back to a research focused career. The ...
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Blood Storage and Preservation
How Is Blood Stored and Preserved? Blood storage is an important process in the blood banking industry as it helps maintain the quality of blood and its medical effectiveness. Blood can be stored in a few different ways, but the most common method is refrigeration.Blood banks depend on donors to provide blood and blood components. When blood is collected from a donor, it must be processed to ...
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Going beneath the surface of skin cancer - Case study
Summary In this Cell Patterns publication, Ozette co-founders and collaborators at the Cancer Immunotherapy Trials Network (CITN) outline a novel method of analysis of single cell data, FAUST, and validate the multiple potential applications. The paper tackles 2 important problems: 1) analysis of complex single cell datasets; 2) prediction of response to immunotherapy in cancer. Manual ...
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Surgical management of an infected external iliac artery interposition graft with a bioengineered human acellular vessel
ABSTRACT Infection of prosthetic vascular grafts can manifest as pain, pseudoaneurysms, or arterial insufficiency in the leg. We present the case of a female patient with a medical history of a right external iliac artery endofibrosis, with a persistently infected synthetic iliofemoral bypass graft, which we replaced with a bioengineered human acellular vessel. At the 12-month follow-up visit, ...
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Establishment of a Stable Organoid Culture System: Customization and Standardization
Prefix Organoids are miniature organs created in vitro from adult stem cells (ASCs) or pluripotent stem cells (PSCs). They form three-dimensional (3D) tissue-like structures through the self-organization, self-renewal, and differentiation capabilities of stem cells. Compared to traditional two-dimensional (2D) cell cultures or spheroids, organoids closely resemble living organs in terms of ...
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Clinical implementation of the Humacyte human acellular vessel: Implications for military and civilian trauma care
ABSTRACT: The incidence of wartime vascular injury has increased and is a leading cause of mortality and morbidity. While ligation remains an option, current resuscitation and damage control techniques have resulted in vascular repair being pursued in more than half of wartime injuries. Options for vascular reconstruction are currently limited to autologous vein or synthetic conduits, choices ...
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