Cytokine And Chemokine Articles & Analysis
15 articles found
In this article, we will explore what cytokines and chemokines are, the significance of the Rat Cytokine and Chemokine Panel, and how it enhances our understanding of immune responses in rats. What Are Cytokines and Chemokines? Cytokines are small proteins secreted by cells ...
A key aspect of studying the immune system involves analyzing cytokines, chemokines, and growth factors—molecules that regulate immune responses and influence disease progression. ...
A Luminex Cytokine Panel allows the simultaneous quantification of multiple cytokines, chemokines, and growth factors in a single sample. ...
Several studies have shown that CpG ODN is able to stimulate cells that express TLR9, initiating an immunomodulatory cascade that culminates in the production of Th1 and proinflammatory cytokines and chemokines. Besides, they also can improve the antigen presenting function of dendritic cells, monocytes and macrophages, induce the proliferation of B cells, ...
Binding of adjuvants to antigens can increase the surface area of the antigen, and the biological effects include (1) deposit effect of antigen; (2) upregulation of cytokine and chemokine expression, and recruitment of immune cells at the injection site; (3) activation of inflammasome; and (4) carrier effects. ...
Most adjuvants induce local inflammation at the site of administration, recruiting various cytokines and chemokines and stimulating CCR7 expression on APCs to facilitate antigen migration to lymph nodes. ...
When an adjuvant activates PRRs, it triggers a cascade of signaling events leading to the activation of immune cells and the production of cytokines and chemokines. This activation, in turn, leads to the recruitment of immune cells to the site of vaccination, improving the immune response. ...
Thymic Stromal Lymphopoietin (TSLP) is a multifunctional cytokine that acts on various cell types, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils, and innate lymphoid cells, affecting their maturation, survival, and recruitment. ...
Their function is critical because they are fundamental building blocks of connective tissue, and chains of GAGs are linked covalently to other proteins such as cytokines and chemokines. Another feature is that they are linked to antithrombin, a protein involved in the coagulation process, so they can inhibit this function, which makes it essential in the ...
Tumors include not only cancer cells but also extracellular matrix (ECM), stromal cells (e.g., fibroblasts and mesenchymal stromal cells), vascular networks and immune cells such as T and B cells, NK cells, and various immunosuppressive cells such as tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), all of which constitute the tumor microenvironment (TME). TME ...
In addition to forming a physical barrier, IECs can also secrete some antibacterial peptides, such as defensins, cytokines and chemokines, including IL8, CCL2, TNF and IL6, etc. These factors can effectively prevent bacteria from entering the intestinal cells. ...
Research has discovered that many cytokines and niche factors play a role in the initiation, progression, and remission of inflammation; however, developing an unbiased model that accurately recapitulates the in vivo inflammatory environment is a challenge. ...
Various colitis symptoms of mice, including disease activity index score [4.55 ± 0.99 (P < 0.001) and 5.12 ± 0.94 (P < 0.001), respectively], colon length [6.18 ± 0.43 mm (P < 0.001) and 6.62 ± 0.47 mm (P < 0.001), respectively], and colon histological score [(5.33 ± 1.03 (P < 0.001) and 4.00 ± 0.89 (P < 0.01), respectively)], were ...
Oral administration ofL. paracasei KBL382 significantly reduced AD-associated skin lesions, epidermal thickening, serum levels of immunoglobulin E, and immune cell infiltration.L. paracasei KBL382-treated mice showed decreased production of T helper (Th)1-, Th2-, and Th17-type cytokines, including thymic stromal lymphopoietin, thymus, and activation-regulated ...
Effects of L. fermentum KBL375 on the Expression of Cytokines or Chemokines in Skin From the in vivo AD Model Figure 3 shows the effects of L. fermentum KBL375 treatment on the expression of innate cytokine TSLP or chemokines including MDC or TARC in skin in the in vivo AD model. ...