Cytokine Storms Articles & Analysis
9 articles found
Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it is more precise in killing tumor cells and significantly reduces toxic side effects while improving efficacy. Cytokines in CAR-T cell therapy Cytokines are pleiotropic and diverse, and enhancing T-cell activation signaling by transgenic expression of ...
Based on the previous research, CXCR7 is the primary receptor responsible for KineTAC-mediated degradation, and alternative cytokines (such as CXCL11 and vMIPII) were also shown to degrade target proteins. ...
However, often still due to unexplainable reasons, the immune system instead stops fighting and attacks itself instead by producing uncontrolled and excessive amount of infection fighting proteins like cytokines, which can lead to a dangerous cytokine storm associated with sepsis. ...
Cytokine storm is also known as cytokine waterfall cascade, or hypercytokinaemia. Cytokine storm was first proposed by Ferrara et al. in 1993 while studying graft-versus-host disease. ...
Cytokines are a class of small molecule proteins secreted by cells that mediate and regulate immune processes, and they act in an autocrine, paracrine and endocrine manner. ...
Today, there are only a few therapies approved to treat COVID-19, but while novel therapies can take decades and billions of dollars to develop, are there opportunities to repurpose existing drugs for new therapies? Our latest whitepaper showcases how CAS Knowledge Graphs reveal new connections and insights that identify drugs to potentially repurpose. Drug repurposing is critical for faster ...
After a lightning round of proposals and reviews, an international team of scientists led by Dr. Camillo Ricordi was granted immediate FDA authorization for a 24-patient clinical trial to test the safety and exploratory efficacy of umbilical cord-derived mesenchymal stem cells (UC-MSCs) to block the life-threatening lung inflammation that accompanies severe cases of COVID-19. The therapy uses ...
One such opportunity is a recombinant protein therapeutic designed to calm an overactive immune system to reduce inflammation and treat the cytokine storm believed to be lethal in severe COVID-19 disease. Cytokine storm, which occurs when a patient’s immune system is too strongly activated, results in severe damage to the ...
Patents are pending in psoriasis and autoimmune diseases, including uveitis, cytokine storm, and preventing the recurrence of leukemia and lymphoma. ...