disease area Articles
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Are clinicians delivering the best care for patients with bladder and bowel dysfunction? A recent study suggests otherwise
People with neurogenic bladder and/or bowel dysfunction often suffer from highly individualized symptoms. It can be difficult to quantify change in an individual’s symptoms using standardized measurement tools, and points to the value of Patient—Centered Outcome Measures. As a relatively new concept, Patient—Centered Outcome Measures (PCOM) aims to place patients, their ...
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Total and cancer mortality of the residents living in a zone of weak technogenic radioactive contamination
Radioactive contamination of the floodplain of the Yenisei River with the wastes dumped by the Krasnoyarsk Mining and Chemical Combine (MCC) might cause external and internal irradiation of a large part of the rural population inhabiting the banks of the Yenisei. Contrary to official data, a few independent studies of the doses received by the exposed population showed that they were quite ...
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RADIUS - Developing new and improved MRI imaging protocols - Case Study
This study aims at developing new and improved MRI imaging protocols in order to obtain better quality images and improved/reduced scan time. We will also assess whether multi-parametric MRI imaging of multiple organs gives the same results when it is repeated on the same person after a period of time, and when it is performed on the same person in different MRI scanners. We hope that, by running ...
By Perspectum
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IPEG 2023: Setting a Foundation for Healthcare Transformation
I recently had the pleasure of attending the IPEG annual meeting in Sorrento, Italy. The collegiality of the surgeons attending the conference was fantastic, and the views of Sorrento and the Island of Capri were stunning. With smaller accessible markets (due to smaller patient volumes and higher incidence of rare disease), specialty areas like pediatrics have been overlooked and under-addressed ...
By Caresyntax
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What is high-throughput detection of gene expression
What Is High-Throughput Detection of Gene Expression? The high-throughput detection of gene expression relies on next generation sequencing technologies to assess the level of expression of all genes in the genome. These technologies have revolutionized transcriptomic research and we are now entering the ultra-high-throughput era of gene expression studies. In this article, we discuss the ...
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Financials keeping the local market in the green: ASX up 0.51% at noon
Financials have been keeping the ASX in positive territory in today’s session, following improved sentiment for financial stocks after the Bank of Queensland (ASX:BOQ) yesterday announced better-than-expected Net Interest Margin performance. This has bolstered financial stocks and the broader market. At noon, the S&P/ASX 200 is 0.51 per cent or 34.10 points higher at 6681.60. The SPI ...
By INOVIQ Ltd
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West Hertfordshire IBD technology study - Case Study
Observational study with retrospective and prospective data collection, for total of 24 months. This is an IBD technology study investigating quantitative metrics for endoscopy, histology and radiology for improved diagnosis and assessment of ...
By Perspectum
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IMOGEN - Contrast-Free Magnetic Resonance Imaging for Breast Disease - Case Study
This is an observational cohort study looking at women, 30 years of age or older with a concern or at risk of suspected breast disease or breast cancer. The proposed study aims to examine the diagnostic performance of non-contrast MRI in breast disease by applying quantitative multiparametric MRI ...
By Perspectum
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Discovery of Pathways that Promote Remyelination
In the evolutionary history of vertebrates, the emergence of myelin has made the transmission of neural signals much faster, and if humans evolve like invertebrate squid, the vertebral diameter of humans may be thicker than that of giant red fir trees. Insulating myelin sheaths encapsulate nerve axons, thereby allowing rapid conduction of action potentials between neurons, and in addition, myelin ...
By Profacgen
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UK Imaging Diabetes Study Seeing Diabetes Clearly - Case Study
Prospective observational cohort study with clinical outcomes data collection. Recruiting adult patients with type 2 diabetes (T2DM) and diabetic retinopathy (DR), who lack history of cardiovascular ...
By Perspectum
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Design and R&D of Covalent Drugs
For a long time, electrophilic groups have been a minefield in drug development. Therefore, in the classic medicinal chemistry textbooks of the past, it is always recommended to avoid introducing functional groups such as epoxide, acridine and Michael receptor into the structure of drug molecules, because these functional groups are highly reactive and may interact with a wide range of biological ...
By BOC Sciences
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Exploring ALS with AI Part II: Understanding familial and sporadic ALS
Part II: Understanding familial and sporadic ALS Welcome to our newest blog series where we investigate Amyotrophic Lateral Sclerosis (ALS) using our AI knowledge mapping tools. Check back for our next installment, in which we analyze transcriptomics from spinal cord samples collected from patients as well as a mouse model. In this second post in our Exploring ALS series, we will begin to dig ...
By PercayAI
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Nanomedicine - the key to improved dermatology treatments?
Blueberry were recently invited to write two commentaries on the challenges of treating skin and nail diseases and the potential for nanotechnology approaches in dermal drug delivery. Here we share a brief overview of these articles. We will all have encountered someone who is dealing with or has previously experienced a common ailment of the skin or nails, such as eczema (atopic dermatitis), ...
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Using AI to Fight a Pandemic: Insilico Medicine Announces Novel Preclinical Candidate for COVID-19 Treatment
Insilico Medicine announced the nomination of a novel preclinical therapeutic candidate for treating COVID-19, designed using the generative chemistry AI platform Chemistry42. The new drug candidate is a 3CL protease inhibitor unique from existing drugs in its class because it can be rapidly produced. While this nomination is a potentially important development for the ongoing COVID-19 pandemic ...
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Developing Plasmodium falciparum malaria vaccines for populations living in areas with stable parasite transmission
Individuals living in areas with stable transmission of Plasmodium falciparum parasites develop substantial protective immunity to the disease during childhood. Because of naturally acquired immunity, which appears mainly to target parasite-encoded Variable Surface Antigens (VSA) on the Infected Erythrocytes (IE), severe and life-threatening disease among adults in such areas is rare. However, ...
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Enzymes for Disease Diagnosis: An Overview
Enzymes are protein molecules that catalyze chemical reactions in living organisms. They are involved in many metabolic processes and play a critical role in maintaining the health of the body. In recent years, enzymes have been widely used in disease diagnosis, providing a quick and accurate way to detect and monitor diseases. Enzymes for disease diagnosis can be divided into two categories: ...
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Biopharma PEG Supplies Cholesterol (Plant-Derived) Used As Excipients for Lipid Nanoparticles (LNPs)
Cholesterol, a derivative of cyclopentane polyhydrophenanthrene, is the main steroid compound in mammals. Most of the traditional cholesterol comes from animal brainstem and lanolin, which is of animal origin and has the risk of carrying animal viruses. Biopharma PEG innovatively uses plant sterols as starting materials to prepare plant-derived cholesterol (CAS NO.: 57-88-5) through biological ...
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Ticks Increasing on Northern California’s Beaches
If you think wooded or grassy areas are the only places where you need to worry about ticks on the west coast, think again. A four-year study of Lyme disease ticks in California has revealed an unusually high number of ticks on and near beaches. The study focused on several Northern California coastal counties and surveyed around 3,000 Western blacklegged ticks, the ticks responsible for ...
By IGeneX
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