disease associated Articles
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Ayurvedic potentials for cellular protection, regeneration and immunomodulation with special reference to resistance against low radiation
The exposure to acute low Linear Energy Transfer (LET) at more than 10 rem or 0.1 Sv due to background radiation, occupation exposure or free radicals appears to be responsible for biological changes that have a health impact on cells, including DNA damage and contribute to the ageing process and to the manifestation of diseases, including cancer. Individuals and subpopulations (cultural groups ...
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Unveiling the Intricacies of DNM1L: Function, Associated Diseases, and Inheritance Patterns
Introduction The human body is a complex network of genes and proteins, each playing a crucial role in maintaining our health. One such gene, DNM1L, has garnered significant attention in recent years due to its vital functions and its association with various diseases. In this blog post, we will delve into the world of DNM1L, exploring its function, the diseases it is linked to, and the ...
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TPD Show Potential For The Treatment of Alzheimer's Disease
Targeted protein degradation (TPD) is a promising strategy in the field of drug discovery. In recent years, targeted protein degradation (TPD) technology has developed rapidly, especially proteolysis targeting chimera (PROTAC), which is the most representative technology of TPD strategy. TPD drugs are one of the hot spots of new drug development in recent years, especially in the field of ...
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Utilization of a 3D bioprinted liver tissue model to evaluate the antifibrotic effects of an ALK5 inhibitor in a TGFß-induced model of hepatic fibrosis
Publication Summary: Compound induced chronic liver injury can lead to initiation of profibrotic processes resulting in sustained production of growth factors and profibrotic cytokines where inflammation, tissue remodeling and repair pathways are activated simultaneously to counteract the injury. Evaluation of potential antifibrotic therapies are limited using conventional non-human animal ...
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Evaluation of the Talis One Covid-19 Test System for the Rapid Detection of Sars-Cov-2 and Emerging Variants
Introduction The discovery of a novel coronavirus in December 2019 in the Wuhan province of China and subsequent global spread has caused a pandemic of the scale not seen since the 1918 H1N1 pandemic. The novel coronavirus, classified as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly infectious and causes coronavirus disease 2019 (COVID-19), a respiratory and vascular ...
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Painting the Picture of Recursion
I’m Anne Carpenter, a member of Recursion’s Scientific Advisory Board since 2014, a few months after the company was launched. I read Chris’ blog post reflecting on Recursion’s early days and thought I could tell my side of the story: watching Recursion get off the ground. I feel a bit sheepish as I recall grilling Recursion co-founders Chris Gibson and Blake ...
By Recursion
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Special Genes May Affect the Level of Lipopolysaccharide in the Body’s Blood
Transfer of lipopolysaccharide from gram-negative bacteria into the systemic circulation of the body leads to the development of endotoxemia, which is detected in cardiometabolic diseases such as cardiovascular disease and obesity in addition to acute infections. Lipopolysaccharide is a virulence factor produced by bacteria, which often triggers systemic inflammation through the body's ...
By CD BioGlyco.
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A Small Protein May Help People with Epilepsy and Other Diseases
For the first time, scientists have elucidated the structure of GABA transporter 1 (GAT-1) using cryo-electron microscopy. The discovery could lead to better new treatments for neurological disorders such as anxiety, autism spectrum disorder, schizophrenia and Parkinson's disease. In determining the structure of this transporter, one of the smallest proteins ever made, researchers have opened ...
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RNA Sequencing Increases the Chance of RNA Biomarker Discovery
Biomarkers are defined as measurable biological characteristics that are associated with normal or pathological conditions. They possess clinical relevance, including diagnostic, prognostic, and predictive values. RNA, not only an essential part of the central dogma, is certainly a relatively untapped resource for biomarker discovery of various diseases. Cumulating data shows that RNA ...
By CD Genomics
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Bioinformatics Workflow for Whole Genome Sequencing
Whole genome sequencing (WGS) has the capacity to greatly enhance genomic knowledge and understand mysteries of life by utilizing the most advanced genetic sequencing technologies. WGS can be used for variant calling, genome annotation, phylogenetic analysis, reference genome construction, and more. WGS tries to cover the whole genome, but actually covers 95% of the genome with technical ...
By CD Genomics
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Diabetomics Lumella - New Point-of-Care Blood Test Kit for Early Detection of Preeclampsia
Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovial joints. Anticitrullinated protein autoantibodies are detected by the CCP test in early disease and predict the development of erosive disease as well as extraarticular manifestations. We recently reported that many RA patients have anti-citrullinated albumin (ACA) ...
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Challenges in Small Molecule Targeted Drug Development
The classical mode of action of small molecule drugs is "occupancy-driven". Since the FDA approved the first oral small molecule targeted therapy for tumors-tamoxifen targeting the estrogen receptor (ER)-in 1977 for the treatment of breast cancer, small molecule drug development has typically focused on screening for high-affinity inhibitors. Small molecule inhibitors can bind to the active sites ...
By BOC Sciences
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Targeted Region Sequencing in Human Disease Studies and Clinical Care
Introduction to target region sequencing Since the introduction of Sanger sequencing in 1977, genetic sequencing has been greatly improved with costs simultaneously falling. With the ability to rapidly produce large volumes of sequencing data, next-generation sequencing (NGS) enables researchers to obtain whole genome or targeted regions of samples. Targeted region sequencing is preferred by ...
By CD Genomics
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CD Genomics Perspective: High-Throughput Sequencing Approach to Explore the Human Microbiome
The Use of Microbiome Sequencing in Cancer Research A growing body of evidence now suggests that human microbial dysbiosis has a crucial role in cancer development and progression. Unlike earlier studies relying on culturing bacteria from the tissue of cancer, high-throughput sequencing methods have enabled genotyping the microbial ecosystem within cancer tissue from hundreds to thousands of ...
By CD Genomics
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LncRNA Sequencing Helps to Find Deep Links to Disease
Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. Therefore, those ...
By CD Genomics
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A Quick Guide to Proteolytic Enzymes
Protease formulations are without a doubt one of the most fully functional dietary supplements in terms of providing significant health benefits. Clinical studies have documented numerous effective benefits and support for people facing a variety of health challenges, including: a) Asthma b) Atherosclerosis c) Autoimmune disease d) Bronchitis e) Cancer f) ...
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Unveiling Gene Isoforms by RNA Sequencing: Detection Methods and Applications
What Is Gene Isoform? Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell type but differ in their coding sequence or in the regulatory elements that control their expression. Alternative splicing is a process in which ...
By CD Genomics
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What is the difference between infection and disease?
Disease-causing microbes are often found in the human microbiome. So, when does the presence of pathogenic microbes indicate an infection? And when does the presence of infection explain disease? What is an infection? What is a disease? A disease associated with microbes is the outcome of interaction(s) between a microbe(s) and its host in which the host suffers some sort of damage. ...
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Array-based Methylation Detection Explores the Mysteries of Cancer
Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene ...
By CD Genomics
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Three scientists won the Wolff Chemistry Award 2022
Recently, the Wolf Foundation published a list of Wolf Chemistry Award winners in 2022, with honors from Professor Bonnie L. Bassler at Princeton University, Professor Carolyn R. Bertozzi at Stanford University, and Professor Benjamin F. Cravatt III at the Scripps Institute. The press release points out that these scientists have made pioneering contributions to understanding the chemistry behind ...
By Profacgen
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