disease development Articles
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Levodopa therapeutics for Parkinson`s disease: new developments
Abstract Levodopa serves as the gold standard of anti-parkinsonian therapy and nearly every patient with Parkinson's disease eventually receives this drug. To improve upon levodopa therapy, several forms of treatment have been devised to augment its actions, and new delivery systems are under development. This new research offers promise for improving outcomes with this highly effective ...
By Sensidose AB
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Development of new levodopa treatment strategies in Parkinson`s disease-from bedside to bench to bedside
Abstract This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson's disease, have been ...
By Sensidose AB
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Integrative Medicine, chronic disease and Tibb
Integrative Medicine (IM) incorporates elements of complementary and conventional medicine into diagnosis and treatment of diseases. It focuses on health and healing by supporting the body's innate healing abilities. The complementary arm of IM can resort to specific therapeutic techniques like acupuncture, or broadly adopt particular medical paradigms such as Homeopathy or Tibb. IM has a role to ...
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Regenerative medicine: new opportunities for developing countries
There has been a major shift in burden of disease in developing countries. Although traditionally associated with industrialised nations, epidemic levels of non-communicable diseases, such as diabetes, cardiovascular diseases and cancer, now threaten the developing world and are straining health systems that are still struggling with persisting levels of infectious disease. Developing countries ...
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Morbidity pattern of pulmonary tuberculosis and housing quality in Lagos metropolis, Nigeria
The intractable problem of tuberculosis (TB) control despite advances in chemotherapy requires additional research effort to unravel the pertinent factors that make the disease preponderant in developing countries. The present study examined the pattern of TB morbidity in Lagos metropolis with the aim of identifying the explanatory factors. Data on reported cases of pulmonary TB were collected ...
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Development of Gene Therapy Viral Vectors for Rare Diseases
In many cases, gene therapy requires a vector to deliver the gene therapy drug to the target cell. Viral vectors have been one of the most widely studied vectors due to their outstanding transduction efficiency and other significant advantages. Viral vector-based gene therapy has now achieved good clinical results. More than a dozen viral gene therapy products have been approved for the treatment ...
By Protheragen
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What is Label-Free Quantification Technique?
The protein label-free quantification technique analyzes protein enzymatic peptide fragments by liquid-quality coupling and compares the signal intensity of the corresponding peptide fragments in different samples for relative quantification of the protein. This method is not dependent on isotope labeling and does not require expensive stable isotope labels as internal reference. The technique is ...
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Bioartificial liver: review of science requirements and technology
Social development in health services is concerned as a global issue. More than nine million people die due to internal organ failure and one percent of this number is due to liver disease. In 1990, more than 27,000 deaths in the USA were caused by liver failure. From the numerous reviews on liver failure and associated support therapies, there is increasing interest in this field throughout the ...
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Decoding Protein Structure Modeling: Unlocking the Key to Life's Mysteries
Proteins are among the most vital molecules in living organisms, playing crucial roles in cell function, signal transduction, and drug development, to name just a few. However, directly observing and studying the three-dimensional structures of proteins is not an easy task. Fortunately, the development of protein structure modeling technology has provided us with a powerful tool to unravel the ...
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Temperature Monitoring Supports the Vaccine Cold Chain
Vaccines play a vital role in society by preventing and eradicating various diseases. Newly developed vaccines such as pneumococcal conjugate vaccine (PCV) and rotavirus vaccines have the ability to save a million lives per year. The response to the 2019/2020 global COVID-19 pandemic resulted in mRNA ultra-low temperature vaccines being developed. It is essential for the efficacy of the vaccines ...
By AKCP
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Understanding The Applications of Immortalized Cell Lines and Exploring Their Future in Biology Research
In the field of biomedical research, immortalized cell lines have proven to be invaluable tools for a wide range of studies. These cell lines, derived from primary cells, possess the unique ability to undergo continuous division, providing researchers with a sustainable and consistent source of cells for experimentation. Additionally, immortalized cell lines have the advantage of maintaining the ...
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Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level
Close-up on chromatin modifications Despite recent advances in spatial transcriptomics to map gene expression, it has not be possible to determine the underlying epigenetic mechanisms controlling gene expression and tissue development with high spatial resolution. Denget al. report on a technique called spatial-CUT&Tag for genome-wide profiling of histone modifications pixel by pixel on ...
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Innovative Diagnostic Development Urges Rare Disease Therapies
Rare diseases are characterized by their low prevalence, affecting a small number of people across the world. These diseases often come with significant challenges, including accurate diagnosis, availability of effective treatments, and limited resources for research and development. However, recent advancements in diagnostics technology hold promise for speeding up the field of rare disease ...
By Protheragen
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Diabetomics Lumella - New Point-of-Care Blood Test Kit for Early Detection of Preeclampsia
Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovial joints. Anticitrullinated protein autoantibodies are detected by the CCP test in early disease and predict the development of erosive disease as well as extraarticular manifestations. We recently reported that many RA patients have anti-citrullinated albumin (ACA) ...
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Editorial: Research, Development and Clinical Trials for Peptide-Based Vaccines
From the eradication of smallpox through to the global response to the COVID-19 pandemic, vaccines have been a cornerstone in the fight against infectious diseases in humans and livestock since the 18th century. Although vaccines against COVID-19 are unlikely to eradicate the disease in the way that the smallpox vaccine did, they have proved very effective in preventing death and hospitalisation, ...
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Epitope Specific Case Study
Published example: Computationally designed epitope specific Multibody binding a cryptic epitope Challenge: Designing an Ab for a cryptic epitope - not exposed to solvent in the native conformation* N terminus covers epitope in the native conformation and desired binding site (epitope) is hidden Biolojic’s solution - epitope specific Antibody which moves the N terminus and ...
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New Technology of PROTACs
Most of the drugs currently in clinical use are based on small molecules and use the "occupancy-driven" mode of action to inhibit the function of proteins and play a role in the treatment of diseases. Different from traditional small molecule inhibitors and antagonists, protein degradation technology has developed rapidly in recent years because of its ability to induce the degradation of ...
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Expanding Our Commitment to Rare Disease Therapeutics
Each year, the last day of February serves as a reminder to pause and reflect on the challenges and unique needs of patients and families living with rare diseases. It is an opportunity for all members of the patient, medical, and scientific communities to shine a light on the urgent need to improve the care and support for those impacted by such conditions. At Moderna, we are working to ...
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What is high-throughput detection of gene expression
What Is High-Throughput Detection of Gene Expression? The high-throughput detection of gene expression relies on next generation sequencing technologies to assess the level of expression of all genes in the genome. These technologies have revolutionized transcriptomic research and we are now entering the ultra-high-throughput era of gene expression studies. In this article, we discuss the ...
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Standing Desk Is Value For Money
The study found that giving 20% staff a standing desk in the office would save A$84 million in health care costs. According to Australia's first assessment of a low cost standing desk, providing a standing office desk for 20% of office staff can save $8,400 in health care costs and prevent obesity, type 2 diabetes and cardiovascular disease and increase the total life of 7492. The researchers ...
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