disease including Articles
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Understanding the Stages: Preclinical Alzheimer`s Disease
Many neurological diseases, including Alzheimer’s disease, can be thought of as continuums, whether the presence and manifestation of the disease are different depending on the stage of the disease. In this article, we provide a high-level overview of the stages in the Alzheimer's disease continuum, with a focus on preclinical Alzheimer’s disease and its importance in patient care and ...
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The Problem with Gene-Modified Cell Therapy Manufacturing
Gene-modified cell therapies (GMCTs) represent the most effective therapeutic platform for many patients with advanced diseases including relapsed and refractory leukemia, non-Hodgkin lymphoma, and other blood cancers [1]. Specifically, chimeric antigen receptor T cell (CAR-T) therapies targeting CD19 have demonstrated remarkable responses and possibly cures in patients with advanced acute ...
By Indee Labs
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Signs of Parkinson’s Disease to Watch For
Parkinson’s disease is a progressive neurodegenerative disease that is most commonly known for affecting movement. It primarily impacts dopaminergic, or dopamine-producing, neurons in a specific area of the brain known as the substantia nigra. Typically, symptoms develop slowly over years and continue to worsen as the disease progresses. While the manifestation of symptoms tends to vary ...
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Nebulised MSC-Derived EVs: A Potential Therapy for E. coli-Induced Pneumonia
Mesenchymal stem cells (MSCs) have shown great promise in cell therapy for various diseases, including lung injury. However, recent research has focused on the therapeutic potential of extracellular vesicles (EVs) derived from MSCs. These EVs contain bioactive molecules that can modulate immune responses and promote tissue repair. In the context of pneumonia caused by Escherichia coli (E. coli) ...
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New Report Launched by WHO – ‘Health in 2015: from MDGs to SDGs’
The World Health Organization (WHO) has launched a new report analysing global health trends since 2000 and looks at the main challenges that will affect health in the coming 15 years. The report titled ‘Health in 2015: from MDGs to SDGs’ identifies the key drivers of progress in health under the United Nations Millennium Development Goals (MDGs). It lays out actions that countries ...
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Bartonella ImmunoBlots Now Available!
The wait is over. Patients with a suspected Bartonella infection are now able to order the IGeneX ImmunoBlots. ImmunoBlots use recombinant antigens to increase sensitivity, specificity and extend species coverage. They effectively replace the Western blot. ImmunoBlots are already available for other diseases including Lyme and Tick-Borne Relapsing Fever (TBRF). We are very excited to now offer ...
By IGeneX
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Project - Sublingual IL2 (BL SLIT I)
The aim of this project is to develop low dose IL-2 for treatment of early onset juvenile Type I diabetes. Low dose injectable IL-2 in animal models has been shown to restore the balance between regulatory and effector T cells and, in this way, can help to reverse autoimmunity and the development of type I diabetes. Looking ahead, we anticipate that having a suitable oral formulation of IL-2 to ...
By BioLingus AG
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Overview Of SFA Therapeutics
SFA Therapeutics’ CEO Dr Ira Spector presents an overview of the company and its platform technology SFA Overview Presentation on YouTube Introduction to SFA Liver Disease and Oncology Programs. SFA Oncology More information here We received US Patent 10,143,669B2; to prevent Hepatitis B progression to HCC, a liver cancer that affects 400 million patients and causes 1 million cancer ...
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Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease risk management in Belgium
Large imports of cattle and meat and bone meal from countries potentially affected by bovine spongiform encephalopathy (BSE) may have led to the BSE agent entering Belgium, and the occurrence of domestic BSE cases. The first case was confirmed in 1997. The ability to avoid amplification of incoming infectivity, as well as to reduce already circulating infectivity, was greatly improved in Belgium ...
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Latest data on the safety and effectiveness of COVID-19 vaccines in children
Childhood vaccinations provide immunity to children against serious infectious diseases before they are exposed to them to prevent illness. Many childhood diseases, such as smallpox and polio, have been almost completely eradicated as a result of widespread, standardized childhood vaccination programs. Some vaccinations, such as those for highly contagious diseases including measles, mumps, ...
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Ayurvedic potentials for cellular protection, regeneration and immunomodulation with special reference to resistance against low radiation
The exposure to acute low Linear Energy Transfer (LET) at more than 10 rem or 0.1 Sv due to background radiation, occupation exposure or free radicals appears to be responsible for biological changes that have a health impact on cells, including DNA damage and contribute to the ageing process and to the manifestation of diseases, including cancer. Individuals and subpopulations (cultural groups ...
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Has the future of complement therapeutics arrived?
Silence Therapeutics, a pioneer in the development of novel small interfering RNA (siRNA) therapeutics, and Mallinckrodt plc, a global biopharmaceutical company, announced the submission of a clinical trial application (CTA) for SLN501, a siRNA therapy targeting the complement C3 protein, on March 23, 2022. Silence will receive a $3 million milestone payment from Mallinckrodt as a result of the ...
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Deletion of vascular endothelial growth factor c (vegf-c) and vegf-d is not equivalent to vegf receptor 3 deletion in mouse embryos
Lymphatic vessels play an important role in the regulation of tissue fluid balance, immune responses, and fat adsorption and are involved in diseases including lymphedema and tumor metastasis. Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) is necessary for development of the blood vasculature during early embryogenesis, but later, VEGFR-3 expression becomes restricted to the ...
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Novel nanoplatform for oral delivery of anti–cancer biomacromolecules
Oral administration of bio–macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. In this regard, nanotechnology promises the new hope and offers advantages such as controlled release, target specific delivery, combinatorial therapy and many more. In this study, we demonstrate the formulation of a novel alginate enclosed, chitosan ...
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New Approaches to Label Proteins Help Track Disease
Scientists at the Francis Crick Institute and Imperial College London have developed a new way to study proteins released by cells, which may spawn new tools to track diseases, including cancer. Biomarkers are invaluable tools that enable physicians to study biology and disease, for example, diagnose disease from blood or tissue samples, predict whether a treatment is effective for an ...
By Profacgen
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Making the Business Case for Office-Based Hysteroscopy Procedures
For OB/GYN practices looking at the possibility of providing office-based hysteroscopy procedures, the benefits such a move would offer patients is a primary consideration. However, practices must weigh those against multiple economic factors—including capital outlay and reimbursement. To help practices make a more informed decision, this paper provides an overview of the business case for ...
By LUMINELLE
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FluGen Announces First Subject Dosed in Phase 1b Clinical Trial of its Intranasal M2SR Flu Vaccine, Co-Administered with High Dose Vaccine, in Older Adults
Study will measure immune responses generated by M2SR and high dose vaccine separately and in combination in the highly vulnerable 65-85 years old population – Funded by the US Department of Defense, this study is expected to yield topline data in 2H 2022 – MADISON, Wis., June 22, 2022 /PRNewswire/ — FluGen, Inc., a clinical-stage vaccine company transforming vaccine ...
By FluGen, Inc.
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TPD Show Potential For The Treatment of Alzheimer's Disease
Targeted protein degradation (TPD) is a promising strategy in the field of drug discovery. In recent years, targeted protein degradation (TPD) technology has developed rapidly, especially proteolysis targeting chimera (PROTAC), which is the most representative technology of TPD strategy. TPD drugs are one of the hot spots of new drug development in recent years, especially in the field of ...
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Cells isolated from donors with nonalcoholic fatty liver disease exhibit disease phenotypes in 3D bioprinted human liver tissue
Publication Summary: The identification of targets and biomarkers and development of therapeutics for nonalcoholic fatty liver disease (NAFLD) may be accelerated by the use of well-characterized primary cell and tissue reagents, as well as improved in vitro human cell-based disease models, including three-dimensional (3D) bioprinted liver tissue. The characteristics of donors from which the ...
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What Is Microbiome and How to Study It
The term microbiome comes from the Greek word micro which means small and bios meaning life. It is defined as "a characteristic microbial community occupying a reasonable well-defined habitat which has distinct physiochemical properties". Many researchers in the past defined microbiome based on different contexts such as ecological and genetic aspects. However, scientists noted some gaps in these ...
By CD Genomics
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