disease progression Articles
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A Treatment Proposal with Lower Extremity Robotic Devices: Performance of Postural Analysis and Determination of Exercises Using the REX Robot
Exercise is an intervention commonly used in the management of multiple sclerosis (MS). The more recent understanding is that exercise is a very important part of maintaining functional independence in individuals with MS. Many studies and research has shown that properly prescribed exercise programs can decrease impairments in MS, as well as improving activities of daily living, and quality of ...
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Signs of Parkinson’s Disease to Watch For
Parkinson’s disease is a progressive neurodegenerative disease that is most commonly known for affecting movement. It primarily impacts dopaminergic, or dopamine-producing, neurons in a specific area of the brain known as the substantia nigra. Typically, symptoms develop slowly over years and continue to worsen as the disease progresses. While the manifestation of symptoms tends to vary ...
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BEAT Continuous non-invasive Lactate Monitoring In Critical Care and Monitoring Disease Progression in Covid-19
Nemaura’s CLM (Continuous Lactate Monitoring) device is based on the BEAT™ platform used in sugarBEAT®, with appropriate adaptations to the sensor chemistry, the algorithm and the mobile app interface. Nemaura is evaluating the timelines for bringing this product to market as a Class 2 approved medical device. ...
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The Role of MMP-3: Insights into Disease Progression and Therapeutic Potential
The MMP Family Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. MMPs are capable of degrading ECM proteins such as collagen, gelatin, laminin, fibronectin, fibrinogen, elastin, and proteoglycans. They were once considered regulators of the extracellular ...
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The Structure of Key Proteins in Parkinson`s Disease Solved
Australian researchers have recently solved a multi-year mystery about Parkinson's disease. They solved the structure of a key protein that is expected to rapidly treat this incurable disease. The findings appear in Nature. For the first time, the researchers took a "live" shot of a protein called PINK1. The findings explain how this protein is activated in cells, thereby initiating the ...
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Single-Cell RNA Sequencing in Drug Discovery and Development
What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes and their gene expression profiles. This information can lead to a better understanding ...
By CD Genomics
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Applications of Single-Cell RNA Sequencing in Drug Discovery and Development
Advantages of Single-Cell RNA Sequencing in Drug Discovery Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular level, scRNA-seq allows researchers to identify distinct cell subtypes and their gene expression profiles. This knowledge enhances our understanding of ...
By CD Genomics
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Fungal Identification by Sequencing: LSU, SSU, and ITS Regions
The mycobiome plays a vital role in processes such as decomposition, symbiosis, and disease progression. Knowing the role of different fungi in these processes is critical to understanding microbial communities and their impacts on the environment. In drug discovery, accurate fungal identification unlocks information about species and biochemical properties. Rapid fungal identification entails ...
By CD Genomics
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Understanding Drug-Disease Relationship Analysis: A Key to Drug Discovery
In the realm of modern medicine, the quest for new and effective drugs to combat various diseases is a continuous journey. Drug discovery, the process of identifying compounds that can potentially treat diseases, has seen a significant transformation in recent years, thanks to advancements in computational biology and artificial intelligence (AI). In this article, we will delve into the ...
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5 Simple Ways to Shine a Light on AMD in your Practice
February is National Age-Related Macular Degeneration (AMD) and Low Vision Month. This disease is the leading cause of blindness, and its prevalence is expected to soar as the world’s population ages, leading to an overwhelming projected demand for AMD care by 2050. AMD Awareness Month is a great time to shine a light on this disease and its impact on patients and their families. ...
By MacuLogix
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Added value of advanced perfusion parameters in Moyamoya patients - Case Study
Introduction Moyamoya disease (MMD) is a cerebrovascular disease characterised by progressive steno-occlusion of the terminal part of the internal carotid arteries, causing a decline in cerebral perfusion pressure (CPP) distal to the steno-occlusion lesion. This will trigger a haemodynamic and metabolic response to preserve the cerebral metabolic rate of oxygen (CMRO2). Cerebral auto-regulation ...
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Modeling NAFLD using 3D bioprinted human liver tissue
Publication Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition that originates as lipid accumulation within hepatocytes (steatosis) and progresses into nonalcoholic steatohepatitis (NASH), characterized by lipid accumulation, inflammation, oxidative stress, and fibrosis. NAFLD is now recognized as the most common cause of chronic liver disease in the western world, with an ...
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Whole Genome Sequencing for Rare Diseases
The diagnosis and treatment of rare diseases have long been a daunting challenge due to their complex and often undefined nature. However, with recent advancements in technology, specifically in the realm of genomics, whole genome sequencing (WGS) has emerged as a powerful tool that has revolutionized the diagnosis and management of rare diseases. This groundbreaking technique offers hope to ...
By Protheragen
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Cytokine Involvement in Inflammatory Immune Disorders
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
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Alzheimer’s and Parkinson’s Disease: A Breakdown of the Differences and Similarities
Alzheimer’s and Parkinson’s disease are both neurological diseases that cause progressive damage to the brain, resulting in a decline in neurocognitive function. While Parkinson’s disease is known for affecting movement and function and Alzheimer’s disease is known for affecting cognition, they are a bit more complex than that. Below, we provide an overview of ...
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Chronic wasting disease outbreak across america
CWD (Chronic Wasting disease) is spreading in the United States. It is an infectious disease affecting deer and elk, leaving them ‘zombie like’, according to experts. CWD has already spread to 24 US states as of August 2019. The disease has been seen to affect animals such as reindeer, moose, elk and various deer species. It has been found in free-ranging deer and elk as well as ...
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From Predicting Adherence to Health Outcomes – The Power of Predictive Insights
Clinical researchers have begun adopting predictive analytics to anticipate a patient’s engagement in a clinical trial, including if and how a patient will adhere to their treatment plan. As these models are fed more patient-level audio and visual data, they have the potential to open up a whole new world of a patient’s lived experience – from how a patient will respond to their ...
By AiCure
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Examining Models of Chronic Obstructive Pulmonary Disease (COPD) and their Application in Other Disease Frameworks
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
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Examining Models of Chronic Obstructive Pulmonary Disease (COPD) and their Application in Other Disease Frameworks
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
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Clonality Analysis Service: A Paradigm Shift in Disease Diagnosis and Treatment
Understanding Clonality Analysis Clonality refers to the origin of a cell population from a single 'parent' or progenitor cell through asexual reproduction or division. This concept is vital in cancer studies as it helps track the development of tumor cells from a single mutated cell. Clonality analysis is thus essential in understanding the evolution and the spread of cancerous cells in a ...
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