Disease Reported In Several Articles & Analysis
35 articles found
Chemokines and their receptors form one of the most intricate signaling networks in immunology. Among them, CCR1 (C-C chemokine receptor type 1) has attracted attention for its dual role as both a guardian of host defense and a potential driver of chronic inflammation and cancer progression. For researchers, CCR1 is more than a seven-transmembrane G protein–coupled receptor (GPCR)—it ...
The advent of next-generation sequencing (NGS) has revolutionized the field of microbiome research, particularly through the analysis of 16S rRNA gene sequencing. This technique allows for a comprehensive understanding of microbial communities, providing insights into their composition and functional potential. This article outlines best practices for the bioinformatics analysis of 16S rRNA ...
Bile, a complex fluid produced by the liver and stored in the gallbladder, plays a crucial role in the digestion and absorption of fats, fat-soluble vitamins, and other essential nutrients. Ox bile extract powder, derived from the bile of oxen, is a natural supplement that has garnered significant interest in the scientific and healthcare communities for its versatile physiological functions and ...
The Triggering receptor expressed on myeloid cells 1 (TREM1) protein has emerged as a pivotal player in the intricate web of immunological responses, particularly in the context of inflammatory diseases. Unraveling the mysteries of TREM1 entails delving into its structure, function, and implications in various pathological conditions, shedding light on its potential as a therapeutic target. ...
The fast-tracking landscape of contemporary gene therapy demands continuous advances in AAV (Adeno-associated virus) formulation development and the enhancement of cGMP (Current Good Manufacturing Practice) capacity. Together, these transformations are essential in producing safe and effective gene therapies for patients. AAV Formulation Development: A Primary Focus In the field of gene therapy, ...
siRNA, with a molecular weight of about 13 kDa, recruits the RNA-induced silencing complex (RISC) to mRNA through base pairing, thereby inhibiting protein translation. The mRNA is targeted for cleavage through the catalysis of the RISC protein Ago2, a member of the Argonaute family. In addition, other Ago proteins (Ago1, Ago3, and Ago4) catalyze endonuclease-mediated degradation of non-specific ...
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. Therefore, the key molecular events in the process of ...
Enzymes are protein molecules that catalyze chemical reactions in living organisms. They are involved in many metabolic processes and play a critical role in maintaining the health of the body. In recent years, enzymes have been widely used in disease diagnosis, providing a quick and accurate way to detect and monitor diseases. Enzymes for disease diagnosis can be divided into two categories: ...
Abera’s vaccine delivery platform works as a plug-and-play system where known or novel antigens can be engineered onto our delivery platform to create effective, multivalent vaccines that are cost-effective and fast to produce. We actively work together with academia and industry to enable the use of our vaccine delivery platform in design and development of new vaccines. Many of these ...
HFJV has been used successfully in infants with severe gas trapping. The techniques used during HFJV in this situation are often described as a "low volume strategy". ...
Many neurological diseases, including Alzheimer’s disease, can be thought of as continuums, whether the presence and manifestation of the disease are different depending on the stage of the disease. In this article, we provide a high-level overview of the stages in the Alzheimer's disease continuum, with a focus on preclinical Alzheimer’s disease and its importance in patient care and ...
These two species have caused the largest and deadliest outbreaks. The new report suggests that researchers could combine these two potent antibodies to create an effective antiviral therapy. ...
Fatty acids, along with glucose and amino acids, are the main source of energy for cell growth and proliferation. Abnormalities in fatty acid metabolism are commonly seen in cancer. A growing number of studies have shown that increased ab initio synthesis of fatty acids in tumor cells is a prominent feature in the development of cancer. And the activation of ab initio synthesis is negatively ...
Self-amplifying RNA vaccines may induce equivalent or more potent immune responses at lower doses compared to non-repli- cating mRNA vaccines via amplified antigen expression. In this paper, we demonstrate that 1 mg of an LNP-formulated dual- antigen self-amplifying RNA vaccine (ZIP1642), encoding both the S-RBD and N antigen, elicits considerably higher neutral- izing antibody titers against ...
The World Health Organization created World Immunization Week to highlight global collective action and promote the use of vaccines that keep all of us protected against disease. This year, the theme is “Long Life for All: In pursuit of a long life well lived.” The COVID-19 pandemic demonstrated the criticality of mRNA vaccines as a tool for quickly and effectively battling ...
Biomarkers are defined as measurable biological characteristics that are associated with normal or pathological conditions. They possess clinical relevance, including diagnostic, prognostic, and predictive values. RNA, not only an essential part of the central dogma, is certainly a relatively untapped resource for biomarker discovery of various diseases. Cumulating data shows that RNA ...
Just stay calm! We’re here to help you. A stuffy or runny nose is a struggle for the child, and as a result, for the whole family, but it should not be dangerous if you know how to treat it properly. In this article, you will learn what causes a runny/stuffy nose in a baby or infant, and how to relieve the symptoms. Why does a runny/stuffy nose occur? A runny or blocked nose is caused ...
ByNosiboo
As the COVID-19 pandemic enters its third year, efforts to mitigate the risk of infection remain critical, especially for vulnerable populations. Recently, Andrea Edlow et al. of Massachusetts General Hospital published a study in the journal JAMA entitled "Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection". The study showed that ...
Another Swedish national study of 30,082 OCD patients found that they were strongly linked to several autoimmune diseases: individuals with OCD had a 43% greater risk of getting any autoimmune disease. ...
The lovely and talented former star of hit TV show The Bachelor is partnering with IGeneX to raise awareness for Lyme disease. The partnership arose organically, following Kelley’s Lyme disease diagnoses through IGeneX testing in 2021. The two have joined forces leading up to Lyme Awareness Month to bring attention to a critical second pandemic- Lyme and tick-borne disease- encouraging ...
ByIGeneX