disease specific Articles
-
Principal Care Management: Reimbursement for High-Value Care Management Services
It’s July and OCM has sunset, EOM is another year on the horizon, and you are wondering how to continue supporting your patients during this transitional period. Regardless of whether participating in a value-based care model is on your roadmap, PCM should be. Principal Care Management (PCM)1 is designed to reimburse specialty practices for providing needed care management services to ...
-
Mortality from selected diseases that can be transmitted by water – United States, 2003–2009
Diseases spread by water are caused by fecal–oral, contact, inhalation, or other routes, resulting in illnesses affecting multiple body systems. We selected 13 pathogens or syndromes implicated in waterborne disease outbreaks or other well-documented waterborne transmission (acute otitis externa, Campylobacter, Cryptosporidium, Escherichia coli (E. coli), free-living ameba, Giardia, Hepatitis ...
-
Effect of Climate Change on Lyme Disease Risk in North America
An understanding of the influence of climate change on Ixodes scapularis, the main vector of Lyme disease in North America, is a fundamental component in assessing changes in the spatial distribution of human risk for the disease. We used a climate suitability model of I. scapularis to examine the potential effects of global climate change on future Lyme disease risk in North America. A ...
-
The Clinical Data Interchange Standards Consortium welcomes Lifebit as a partner
What is the Clinical Data Interchange Standards Consortium? The Clinical Data Interchange Standards Consortium (CDISC) is a global, not-for-profit organisation that develops data standards across all the healthcare sector. Founded in 1997, over the last 20+ years CDISC has provided guidance on the transformation of clinical data from incompatible into interoperable formats so that it is usable, ...
By Lifebit
-
Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury
Abstract Reactive astrocytes are associated with every form of neurological injury. Despite their ubiquity, the molecular mechanisms controlling their production and diverse functions remain poorly defined. Because many features of astrocyte development are recapitulated in reactive astrocytes, we investigated the role of nuclear factor I-A (NFIA), a key transcriptional regulator of astrocyte ...
-
Indication prioritization for a CCR6 inhibitor In collaboration with big pharma - Case Study
The Challenge: With a drug in pre-clinical stage, our client was looking for the first indication to go into clinical ...
By CytoReason
-
Indication selection for anti-PDx combination therapy In collaboration with big pharma - Case Study
The Challenge: One of the most common challenges in immuno-oncology is identifying the indications and patient populations that would benefit from a specific therapy, especially on top of Standard of Care (SOC) treatments. Our platform tackled this challenge of indication prioritization and patient stratification for a combination of a specific target (A) with an anti-PDX drug that one of our ...
By CytoReason
-
Unveiling the Intricacies of DNM1L: Function, Associated Diseases, and Inheritance Patterns
Introduction The human body is a complex network of genes and proteins, each playing a crucial role in maintaining our health. One such gene, DNM1L, has garnered significant attention in recent years due to its vital functions and its association with various diseases. In this blog post, we will delve into the world of DNM1L, exploring its function, the diseases it is linked to, and the ...
-
New Technology to Promote Drug Development-AI Technology
For a long time, the research and development of each new drug has faced the challenges of high cost and long cycle. In response to these challenges, major pharmaceutical companies have shifted from targeting common diseases to developing drugs for specific diseases. At the same time, these companies are constantly looking for new technologies for new drug development, such as high-throughput ...
By BOC Sciences
-
Sifting Nuggets of Truth out of the AI Hooplah
A panel of experts took a crack at the subject of artificial intelligence to help us sort out how much of a near-term impact the technology could realistically have in healthcare. With the topic of artificial intelligence filling up our news feeds and dinner conversations, it’s almost too easy to get swept up in the hype of it all. This week at the J.P. Morgan Healthcare Conference in ...
-
Project - Healthy people, healthy business
The COVID-19 pandemic has placed health and wellbeing at the forefront of the global agenda, revealing an urgent need to strengthen healthcare systems and build capacity and preparedness for health emergencies as well as routine care. The pandemic has also underlined inequalities, raising significant questions around access to healthcare and healthy lifestyles for the most vulnerable in our ...
-
Unleashing the Power of AAV Manufacturing for Large Scale Production in Biopharma
Adeno-associated viruses (AAV) have emerged as safe and effective vectors for gene therapy and the advancement of biopharmaceutical research. Today, navigating the complex landscape of AAV manufacturing has become a focal point for professionals in the biopharma industry looking to exploit this technology in the development of breakthrough treatments. Large-scale production of AAV vectors is a ...
-
The Mode of Action of Basic Proteins Involved in Cancer and Alzheimer's Disease Found
These proteins belonging to the HAT family are essential for life because they transport amino acids to the cell membrane. Although members of the family are nearly identical, they selectively transport certain amino acids. This specificity determines their involvement in specific functions, such as cell growth or neuronal function, and consequently in related diseases, such as cancer or ...
-
The Significance of Raw Enzymes in the Success of mRNA Vaccines
In the ever-evolving landscape of global healthcare, mRNA vaccines have emerged as an excellent tool in the fight against infectious diseases. This article explores the intricate and indispensable role that raw enzymes play in the manufacturing of mRNA vaccines, delving deep into their significance and impact on vaccine production. As we venture into this fascinating world, we will gain a ...
-
The Protein Data Bank has Over 200,000 Structures
Structural biology is an important field in drug discovery as it helps researchers understand the three-dimensional structure of proteins and how they interact with other molecules. This knowledge is crucial in developing new drugs as it allows scientists to target specific proteins and understand how they contribute to diseases. One of the most important resources in structural biology is the ...
-
Shining a Light on Drug Delivery: The Rise of Fluorescent Liposomes
Imagine tiny spheres, smaller than a red blood cell, glowing as they navigate the labyrinthine corridors of the human body. These aren't fireflies, they're fluorescent liposomes, a cutting-edge tool in the world of drug delivery and biomedical research. What are liposomes? Liposomes are microscopic bubbles made from phospholipids, the same fatty molecules that make up cell membranes. These ...
-
Plant-based cures for Vector-borne disease
Herb- and plant-based medicines have been used for as long as 60,000 years, with the first written record dating to 7,000 years ago. While these medicines have survived scientific evaluation with varying success, one in four medications currently used has a plant-based origin. One of the most successful medications treats a vector-borne disease. With all this history, why aren’t we ...
-
Single-Cell RNA Sequencing in Drug Discovery and Development
What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes and their gene expression profiles. This information can lead to a better understanding ...
By CD Genomics
-
Drug Delivery: What do Patients and Providers Want?
Citation: Huddleston M, Estep J, “Drug Delivery: What do Patients and Providers Want?” ONdrugDelivery, Issue 124 (Sep 2021), pp 10–14. Matthew Huddleston and Jennifer Estep discuss current drug delivery options and the value of convenient care. Worldwide, patient and provider preferences are changing due to the covid-19 pandemic. The need to reduce patient exposure to the ...
-
California Prop65 list
1. Tetrahydrocannabinol (THC) Tetrahydrocannabinol (THC) is an active ingredient in Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom since 2010 as a mouth spray for people with multiple sclerosis to reduce neuropathic pain, spasticity, overactive bladder, and other symptoms. Nabiximols (as Sativex) is available as a prescription drug in ...
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you