disease states Articles
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Parkinson`s disease therapy: tailoring choices for early and late disease, young and old patients
Abstract Advances in the understanding of basal ganglia circuitry and its altered function in disease states such as Parkinson's disease (PD), coupled with new insights into the mechanisms of cell death and new findings from therapeutic clinical trials, are being translated into clinical practice. Although levodopa (L-Dopa) remains the most effective drug in the symptomatic treatment of PD, ...
By Sensidose AB
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Genetic tools for select-agent-compliant manipulation of burkholderia pseudomallei
Department of Microbiology, Immunology and Pathology, Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Colorado State University, Fort Collins, Colorado 80523-1682, and School of Medical Science and Institute for Glycomics, Griffith University—Gold Coast Campus, Gold Coast, Queensland 9726, ...
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The Importance of Celebrating Progress for Your Child with Short Bowel Syndrome
“Parent” may very well be the most important and rewarding job title you will ever have. As a parent, you have three primary goals: (1) set a good example, (2) instill important values, and (3) encourage your child’s happiness. Navigating the early stages of child development and care can be both exciting and exhausting. Your precious bundle of joy comes into this world and ...
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Editorial: Quantitative Susceptibility Mapping in Neurodegeneration
Introduction Magnetic resonance imaging offers a wide variety of contrast mechanisms to study soft tissue in the body. Using the complex data from the SWI scans, it is possible to produce magnetic source images using a novel reconstruction method that takes the phase data and reconstructs what is referred to as a quantitative susceptibility map (QSM). The phase images represent local frequency ...
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Nanoparticulate systems for oral drug delivery to the colon
A review of oral drug delivery to the colon is a difficult but desirable method of administration. In order to target the colon the dosage form must overcome the barriers presented by the gastrointestinal tract including the steep pH gradient, binding to the mucus layer, premature clearance, and premature cellular uptake. Nanoparticles have been fabricated via a number of methods and designed ...
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Betting big on quantitative neurobiomarkers
Introducing Beacon Biosignals: a neurotechnology company founded to develop machine learning-enabled EEG neurobiomarkers and accelerate precision medicine for any disease state affecting the brain Founded by MD/PhDs and engineers from Harvard and MIT, Beacon is propelled by the vision of a computing platform designed to scale the interrogation of large brain datasets with unprecedented ...
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Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury
Abstract Reactive astrocytes are associated with every form of neurological injury. Despite their ubiquity, the molecular mechanisms controlling their production and diverse functions remain poorly defined. Because many features of astrocyte development are recapitulated in reactive astrocytes, we investigated the role of nuclear factor I-A (NFIA), a key transcriptional regulator of astrocyte ...
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Using the Electronic Foodborne Outbreak Reporting System (eFORS) to Improve Foodborne Outbreak Surveillance, Investigations, and Program Evaluation
Challenges exist in comparing foodborne disease outbreaks (FBDOs) across states due to important differences in reporting practices and investigations. Variables such as FBDO size, population size, number of tourists, and suspected etiology are important to consider when interpreting FBDO data. Analysis of eFORS data can be valuable in improving state FBDO investigations. From 2000 to 2005, ...
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Leishmaniasis Vaccine - Case Study
The World Health Organization in its report on Neglected Tropical Diseases has stated that there is overwhelming evidence to show that the burden caused by many of the 17 diseases that affect more than 1 billion people worldwide can be effectively controlled and, in many cases, eliminated or even eradicated. Leishmaniasis caused by Leishmania spp is one such example and poses a grave health risk ...
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Dyve Biosciences enrolls first patient in gout trial
Dyve Biosciences announced today that it enrolled its first patient in the Phase 2 clinical study of its DYV-700 topically administered therapeutic for acute gout treatment. Thousand Oaks, Calif.–based Dyve won FDA clearance to begin the Targets Phase 2 trial in December 2019. The double-blind, placebo-controlled, randomized clinical trial is set to evaluate the efficacy of DYV-700 in ...
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The Notable Breakthroughs in Drug Discovery with SILAC Technique
Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) is a powerful technique that allows for the quantification and characterization of proteins in cells and organisms. It involves the substitution of specific amino acids with their isotopically labeled counterparts in cell culture media. This labeling enables researchers to track and compare protein expression levels, protein-protein ...
By BOC Sciences
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An In-depth Analysis of hERG (IKr, Kv11.1): Its Function, Role, and Importance
Introduction hERG, which stands shorthand for the human Ether-à-go-go-Related Gene, generates the protein responsible for a certain type of potassium channel in the human heart, denoted as IKr or Kv11.1. The role of this potassium channel is fundamental for normal cardiac function, playing a vital role in the termination of the cardiac action potential and ultimately contributing to the ...
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Four Well-Established Strategies Used in Hit Identification
The major preclinical phases of peptide drug discovery encompass initial target identification and validation, hit identification, high throughput screening, lead optimization, etc. Among them, hit identification is one of the most critical steps in identifying peptides that can interact with well-validated targets. Hit identification (HI) follows the process of target validation, in which the ...
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Why open-source AI platforms are the future of patient health tracking in clinical trials
Imagine you’ve just been diagnosed with cancer and you’re enrolled in a clinical trial for a promising new drug. You notice that after chemotherapy you struggle with occasional fatigue. Yet, whenever you visit your doctor every couple of weeks, you feel fine. This is not only a frustrating experience for patients, but it can also compromise the safety data in a clinical trial. The ...
By AiCure
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Unlocking the Possibilities of Customized Ionic Channel Expression Systems
Ionic channels, which are proteins present in the membranes of all living cells, are gaining significant importance in the fields of bio-medicine and biotechnology. They are responsible for the transmission of signals across cell membranes and are instrumental in multiple biological processes. This raises the demand for a systematic mechanism that can control their expression. The customized ...
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Enhancing Human Gut Tissue Models through Gene Editing
The variety of normal and diseased human tissues needed to perform comprehensive screening of drug candidates is a key resource for next-generation preclinical models, but obtaining these tissues is challenging. Gene editing enables Altis Biosystems to offer a diverse array of RepliGut® human gut models tailored for specific research programs. Many Challenges Around Accessing Tissues ...
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How much do animal models play a role in drug development?
Published by Vijay K Singh and Thomas M Seed on September 3, 2021, in Expert Opinion on Drug Discovery and deals with the necessity of animal models for modern drug research in the direction of animal strains, animal models, requirements, and pathways for developing new drugs. The use of experimental animal models in drug development aids in the understanding of disease and/or related conditions' ...
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How Does Altis Biosystems Envision the Future of the Pharma/Biopharma Industry?
There is a growing need to address the high failure rate of drug candidates as they progress through clinical trials. Altis Biosystems aims to bring its technological advances to the forefront, enabling the drug development process to more effectively translate results from preclinical experiments to late-stage clinical trials. Breaking the Conformity of Inadequate Testing Platforms The ...
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Computer Vision-Based Digital Biomarkers Could Enable Faster and More Accurate In Vivo Assessment of Disease
At Recursion, we are working to decode biology and industrialize drug discovery. We have successfully executed over 82 million phenomic experiments and inferred over 179 billion biological relationships in our quest to identify promising novel therapeutic approaches. Now, we are extending our industrialized approach to petabytes of pre-clinical in vivo studies. Digitalizing in vivo studies ...
By Recursion
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Applications of Single-Cell RNA Sequencing in Drug Discovery and Development
Advantages of Single-Cell RNA Sequencing in Drug Discovery Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular level, scRNA-seq allows researchers to identify distinct cell subtypes and their gene expression profiles. This knowledge enhances our understanding of ...
By CD Genomics
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