Drug Approval Articles & Analysis: This-Year
3 articles found
Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While effective, oral dosing requires high systematic concentrations, which often lead to gastrointestinal side effects and liver toxicity. A targeted approach that delivers these drugs directly to the lungs ...
One such approach involves the repositioning, or repurposing, of drugs already FDA approved in either non-oncology disease states and/or approved in a limited number of tumor types. The repurposing of these drugs for new indications represents an opportunity to circumvent the time and investment that must go into the discovery, ...
Absorption refers to how a drug is absorbed into the bloodstream after administration. Factors influencing this process include the drug’s solubility, chemical stability, and the route of administration. ...