Drug Discovery Development Articles & Analysis
48 articles found
In cancer research, these vectors allow for the investigation of gene function and the potential development of gene therapies targeting tumor cells. In regenerative medicine, they have the capability to correct genetic disorders by delivering therapeutic genes to affected tissues. Moreover, in model organism studies, CRISPR/Cas9 lentiviral systems are employed to create stable ...
In this white paper, Predictive Oncology (POAI) highlights a recent successful project in partnership with the University of Michigan Natural Products Discovery Core (NPDC) through the ACE program. The ACE program supports academic researchers in their early drug discovery and development initiatives by providing ...
In the realm of pharmacology and drug development, the assessment of drug permeability is essential. One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. ...
Nutrition and Functional Foods: Profiling glucosinolates in vegetables can guide the development of functional foods with enhanced health benefits. Pharmaceutical Research: Identifying bioactive glucosinolate metabolites can aid in drug discovery and the development of nutraceuticals. ...
Due to their crucial roles in physiological and pathological processes, nuclear receptors have emerged as significant targets for drug discovery and development. The Importance of Nuclear Receptor Screening The screening of nuclear receptors is fundamental in understanding how these proteins interact with potential therapeutic agents. ...
Understanding the complex world of drug discovery and development necessitates familiarity with key players in cellular communication. ...
Alfa Cytology has introduced its advanced drug development services for brain tumors. Alfa Cytology, celebrated for its cutting-edge biotech solutions and extensive tumor research expertise, has recently introduced brain tumor drug development services, designed to empower researchers in understanding the intricacies and unique ...
Boasting a high fecundity rate, rapid development, exceptional regenerative capabilities, and optical clarity during embryonic stages, Zebrafish offer an excellent platform for researchers. These traits make them the models par excellence for studying embryonic development, genetic disorders, organogenesis, and tissue regeneration. ...
Functions of PeptidomimeticsPeptidomimetics have a wide range of functions and are being increasingly explored in drug discovery and development because of their potential therapeutic benefits. Some of the main functions of peptidomimetics include inhibiting or modulating enzymes & proteins, targeting specific receptors, and enhancing ...
AI also plays a pivotal role in the development of gene therapies. By analyzing vast amounts of genomic data, AI algorithms can identify potential genetic targets for therapeutic intervention. ...
Conditional knockout cell lines provide better control of gene expression and provide a more physiologically relevant model for studying the role of target genes and drug discovery. Recently, with the development of the CRISPR/Cas9 gene editing technology, it has become possible to use this technique to generate conditional knockout cell lines. ...
This information aids in understanding the drug's mechanism of action and optimizing drug design.3. Optimization of Drug Formulations and Drug Delivery SystemsCD technology can help analyze conformational changes of drug molecules in different formulations, or their encapsulation status in carrier systems (such ...
Oncology drug development makes up almost half of the annual R&D expenditure of biopharmaceutical companies. ...
AI also plays a pivotal role in the development of gene therapies. By analyzing vast amounts of genomic data, AI algorithms can identify potential genetic targets for therapeutic intervention. ...
This dynamic interplay between computational algorithms and molecular models is the key to unlocking the mysteries that govern the interactions between drugs and protein targets. Beyond algorithms and simulations, the true power of protein-small molecule docking lies in its tangible impact on drug discovery and development. ...
Peptides are a key ingredient in many bodybuilding supplements and skin rejuvenation products due to their ability to promote collagen production and help muscle recovery. They also play a vital role in drug discovery and development because of their tunable properties and ability to interact with various biological targets. ...
They are essential in unraveling the molecular mechanisms underlying cell death and are instrumental in drug development, cancer research, and developmental biology. Types of Apoptosis Assays Morphological Assays: These assays examine the characteristic morphological changes that occur during apoptosis. ...
Discovery of drug targets and lead compounds Many effective agents currently in use, such as cyclooxygenase inhibitors like rofecoxib and cholesterol-lowering drugs like simvastatin, target lipid metabolizing enzymes and thus regulate lipid metabolic networks. ...
For example, cells expressing the GFP reporter gene will produce a clear fluorescent signal, thus highlighting the cells expressing the gene of interest. Drug Discovery and Development: Due to their ability to provide real-time and highly visible readouts, reporter lentiviral systems play a critical role in drug efficacy and ...
One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. ...