Drug Efficacy Articles & Analysis: Older
61 articles found
Pharmaceutical Development: These cell lines are essential in the drug discovery pipeline, allowing for high-throughput screening and functional assays to evaluate drug efficacy and safety. ...
Obesity is a significant contributor to respiratory disorders such as Obesity Hypoventilation Syndrome (OHS) and sleep apnea, both of which are characterized by reduced respiratory chemosensitivity. These conditions not only impair breathing but also exacerbate the health risks associated with obesity. Recent research from Rivera (2024) investigates the potential of setmelanotide, a ...
Liposomes, spherical vesicles composed of one or more phospholipid bilayers, have garnered significant attention in the field of drug delivery due to their unique properties. These nanocarriers offer a promising approach to overcome challenges associated with traditional drug administration, enhancing therapeutic efficacy while minimizing side ...
Medical advancement relies on clinical trials, which are essential for the development of safe and effective innovative treatments. However, the success and general applicability of these treatments heavily depend on the diversity of the participants involved¹?³. This blog explores the importance of achieving data diversity in clinical trials to enhance clinical trial results and ...
Functions of PeptidomimeticsPeptidomimetics have a wide range of functions and are being increasingly explored in drug discovery and development because of their potential therapeutic benefits. ...
Pharmacokinetic studies serve as the foundation for understanding the drug's bioavailability – the degree and rate at which an administered drug reaches the systemic circulation. ...
The presence of these impurities can affect the efficacy, safety, and stability of drugs. Therefore, the detection and analysis of glycosylation impurities are crucial in ensuring the quality and therapeutic effectiveness of pharmaceutical products.What are Glycosylated ...
Also, Protein-Protein Interaction Sequencing can be applied to drug target screening and effectiveness evaluation. By studying protein interactions, new drug targets can be discovered, further facilitating drug screening and efficacy evaluation.Although Protein-Protein Interaction Sequencing has extensive applications in life ...
Antibody-drug conjugates (ADCs) are a new class of drugs that combine the advantages of both antibodies and small molecule toxins. ...
Dr. Kate Sasser from Tempus led a discussion on the potential of antibody-drug conjugates (ADCs), their challenges in targeting tumor antigens, and the future of cancer treatment with Dr. Daniel Johnson, Dr. Funda Meric-Bernstam, and Dr. Kellogg Parsons. The oncology field is rapidly advancing with the development of antibody-drug conjugates (ADCs), offering new hope for ...
ByTempus
CD can differentiate the different chiral forms (enantiomers) of drugs, which is critical to ensuring drug safety and efficacy.2. Study of Drug and Target Molecule InteractionsCD can be used to analyze the binding mode of drugs to their biological targets (such as proteins, nucleic acids, etc.). This information ...
From screening vast libraries of small molecules to optimizing existing drugs for enhanced efficacy, this technique serves as a valuable guide for researchers and pharmaceutical companies. ...
Risks of HCPs In general, HCP constitutes the major process-related impurity in the drug product in addition to the target protein. The main risk associated with HCP is immunogenicity and they have the potential to affect the safety and efficacy of a given drug product. ...
It involves the attachment or fusion of antibodies with other bioactive substances to enhance their efficacy in diagnostics and therapeutics. One key advantage that modified and conjugated antibodies have is their potential use in targeted drug delivery, especially in oncology. ...
Monitoring changes in lipid metabolism in the body after the action of drugs, and timely response to changes in the body's physiological and biochemical state, is helpful to evaluate the efficacy of drugs and determine possible side effects. Therefore, lipidomics can also be used as an auxiliary means to evaluate the efficacy of ...
SN38-BSA is a bioconjugate product that is effectively revolutionizing the field of drug delivery. This article focuses on understanding its makeup and how bioconjugation is instrumental in its function and efficacy. ...
Radioactive drug conjugates (RDCs), as a particular form of coupling drugs, are formed by combining radioactive isotopes with disease-targeting molecules. ...
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. ...
Polymer nanoparticles can also be engineered to release drugs in a controlled manner, increasing their efficacy and reducing potential side effects. ...
For example, cells expressing the GFP reporter gene will produce a clear fluorescent signal, thus highlighting the cells expressing the gene of interest. Drug Discovery and Development: Due to their ability to provide real-time and highly visible readouts, reporter lentiviral systems play a critical role in drug efficacy and toxicology studies. ...