drug exposure Articles
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Prednisolone impairs embryonic and post‐hatching development and shell formation of the freshwater snail, Physa acuta
The aim of the present study was to investigate the lethal and sublethal effects of prednisolone (PDS) exposure on the embryonic and post‐hatching stage of the freshwater snail, Physa acuta. The egg masses were exposed for 14 d to PDS concentrations ranging from 15.6 to 1000 µg/L. PDS treatments from 125 to 1000 µg/L resulted in significant decline in growth, survival, heart rate and notable ...
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UCT Clean Screen® DAU Cited in Umbilical Cord Drug Testing
Analysis of umbilical cord samples offers forensic toxicologists a method for evaluating maternal drug intake patterns. These matrices may be an uncommon sample for many laboratories, but for those that are tasked with the challenge, solid phase extraction offers the most efficient methodology for the analysis of said compounds. An estimated 5% of expectant mothers use illicit drugs during ...
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Policy Management – DCSCA – Drug Supply Chain Integrity
When the Drug Quality and Security Act (DQSA) was signed by President Obama on November 27, 2013, advocates hoped that the confusing patchwork of State laws governing drug pedigree and tracing would finally be replaced by a comprehensive solution for the ‘3T’s’ (Transaction History, Transaction Statement, and Transaction Information) of the increasingly complex pharmaceutical ...
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Array-based Methylation Detection Explores the Mysteries of Cancer
Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene ...
By CD Genomics
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What makes Biodegradable Microspheres ideal for Controlled-release Drug Delivery?
Patient-centric drug development is a divisive concept. Dismissed as a buzzword by some. Adopted extensively by others. It has, nevertheless, gained enormous traction over the last decade. This new approach to treatment incorporates patient perspectives into drug development. A key benefit is the keener focus on convenience and safe drug administration. Traditional approaches, prioritising ...
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In Silico Development of Combinatorial Therapeutic Approaches Targeting Key Signaling Pathways in Metabolic Syndrome
Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. We ...
By VeriSIM Life
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A hybrid modeling approach for assessing mechanistic models of small molecule partitioning in vivo using a machine learning integrated modeling platform
Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone, time and cost intensive and lack reproducibility in clinical settings. The paper demonstrates how a computational platform integrating ...
By VeriSIM Life
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Liposomes in Anti-tumour Drug Carriers
Introduction Chemotherapy with anti-tumor agents is currently one of the most important systemic treatments for cancer. However, direct treatment with drugs lacks specificity and sensitivity and tends to attack normal cells indiscriminately, resulting in side effects. Liposomes, as drug carriers, provide a superior solution for maintaining or enhancing the efficacy of chemotherapy while reducing ...
By BOC Sciences
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Effects of trophic exposure to diclofenac and dexamethasone on hematological parameters and immune response in freshwater fish
The aim of this work was to evaluate the effects of diclofenac and dexamethasone on hematological parameters and immune response in the fish species Hoplias malabaricus after trophic exposure. Fish were fed twice every week with Astyanax sp., which was submitted to intraperitoneal (i.p.) inoculation with diclofenac (0, 0.2, 2.0, or 20.0 µg/Kg) or dexamethasone (0.03, 0.3, or 3.0 µg/Kg). After ...
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What’s the 2019 DSCSA Requirement and Why Was it Delayed?
The Drug Supply Chain Security Act (DSCSA) is Title II of the Drug Quality and Security Act (DQSA), which was enacted to enhance FDA’s ability to protect consumers from exposure to potentially harmful drugs. The act outlines steps to build an electronic, interoperable system to identify and trace certain prescription drugs as they are distributed in the United States. New requirements ...
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Stability Analysis: A Meaningful, Impactful and At-the-Forefront Tool for Pharmaceutical Science
In the field of pharmaceutical science, stability analysis plays a crucial role in ensuring the safety and efficacy of pharmaceutical products. It is a complex and multifaceted process that requires thorough investigation and understanding of various influencing factors. Stability analysis consists of different methods such as influencing factors analysis, long-term accelerated shelf-life ...
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Glycosylation of Fc Fusion Proteins: Insights into its Biological Significance
Fc fusion protein (Fc-Fusion) has a complex and diverse molecular structure, and may contain glycosylation modification sites at amino acid 297 of its Fc fragment and the Fab region of some molecules. Moreover, its biological ligands are structurally diverse, and their glycosylation modifications may also be complex, usually involving multiple N-glycan and O-glycan sites and a large number of ...
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Kurin, Inc. honored by MD Tech Review in annual listing of top Infection Control solutions
The New Standard for Blood Culture Collection Sepsis, is a life-threatening condition caused when the body’s response to an infection goes out of balance, which triggers changes that damage other organs. This deadly infection affects almost 1.7 million people a year in the U.S. and kills nearly 270,000 people. To date, blood cultures remain the gold standard for determining if a patient ...
By Kurin, Inc.
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