drug related Articles
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Early efficacy signals in ovarian cancer patients in ongoing Ph1 trial: Poster reporting findings presented at SITC 2020 Annual Meeting
ENB Therapeutics reports preliminary data from the ongoing Phase 1/2 trial assessing the safety and efficacy of lead product ENB-003 in combination with pembrolizumab. Safety data are encouraging with no significant drug related safety events from the first 3 dosing cohorts. Best overall responses from the first 6 patients include 2 disease stabilizations and 1 confirmed partial response. The ...
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Drug adherence in Parkinson`s disease
Abstract Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor ...
By Sensidose AB
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India's new patent regime: aiding 'access' or abetting 'genericide'?
This paper considers the impact of the new Indian patent regime on the important issue of access to affordable drugs. Access is dependent, in part, on the ability of generic manufacturers to produce cheap generic drugs. Working with the bird flu patent example, this paper will demonstrate that far from abetting 'genericide', the new regime provides adequate legal windows to aid the continued ...
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How CEFALY Can Help Migraineurs Keep Calm During the Coronavirus Outbreak
The novel coronavirus, or COVID-19, and its health implications have understandably caused great concern across the globe, and with good reason. The World Health Organization has declared the virus a pandemic and said the number of affected countries has tripled in two weeks. There are now upward of 170,000 cases worldwide and more than 6,600 deaths. People throughout the world are making ...
By CEFALY
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CMC Regulatory Considerations for ADCs
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs have been approved worldwide, of which the FDA has approved 13 ADCs for various cancers, including Adcetris®, Kadcyla®, Besponsa®, Mylotarg®, Lumoxiti®, Polivy®, Padcev®, Enhertu ®, Trodelvy® and Blenrep®. As ...
By BOC Sciences
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Better patient safety
Customer: GE Healthcare Challenge: Increasing patient safety in surgery and intensive care through more accurate monitoring. Solution: Development of measurement parameters for the adequacy of anesthesia and analgesia. Key benefits: More precise monitoring of the level of anesthesia and analgesia. Preventing excess medication which can damage the patient's vital functions. Cost-efficiency ...
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An In-depth Analysis of hERG (IKr, Kv11.1): Its Function, Role, and Importance
Introduction hERG, which stands shorthand for the human Ether-à-go-go-Related Gene, generates the protein responsible for a certain type of potassium channel in the human heart, denoted as IKr or Kv11.1. The role of this potassium channel is fundamental for normal cardiac function, playing a vital role in the termination of the cardiac action potential and ultimately contributing to the ...
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SmartTab Completes Gastric Environment Validation Study for InjectTab™ Platform
What if you were able to simply take a pill to receive the medication you’re used to receiving through a shot, like insulin? As a leading innovator and disruptive drug delivery company, SmartTab is driving the future of drug delivery to places people would have never expected it to go and injections with a conventional syringe and needle will soon be a thing of the past. SmartTab's ...
By SmartTab
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Improving drug loading efficiency and delivery performance of micro– and nanoparticle preparations through optimising formulation variables
In this report, we briefly introduce our recent studies related to drug delivery systems using biodegradable materials, PLGA, PLA or chitosan to prepare submicroparticles or microparticles for carrying vaccine, protein or small molecule drugs. These preparations were prepared by spray dried or solvent extraction methods. In addition, liposomal formulations containing various lipids and pegylated ...
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Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae
Phthalates are compounds used in polymers to increase their flexibility and are now ubiquitous in the environment due to widespread use. As few studies have focused on the adverse effects of these chemicals in aquatic species, this study aimed to determine the effects of phthalate diesters in amphibians. Western clawed frog (Silurana tropicalis) tadpoles were acutely exposed to water spiked ...
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The changing role of technology suppliers in the pharmaceutical industry: the case of drug delivery companies
In this paper, preliminary results of a research project on strategies of drug delivery companies (DDC) are presented to discuss the changing role of technology suppliers in the pharmaceutical industry. Changes in the pharmaceutical industry are presented briefly and related to developments in the drug delivery industry. The early observations are contrasted with existing views from the ...
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Nanopharmaceuticals I: nanocarrier systems in drug delivery
To achieve maximum pharmacological effects with minimum side effects of drugs, drugs should be delivered to target sites without significant distribution to non-target areas. Using pharmaceutical nanocarrier systems for drug delivery is a useful delivery platform for improving target specificity, therapeutic activity, and reducing toxicity of drugs. Various sophisticated nanocarrier systems have ...
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Some Basic Facts about Active Pharmaceutical Ingredient Excipients for Drug Discovery
Pharmaceutical excipients are substances formulated together with active pharmaceutical ingredients (APIs) of the drug, and excipients account for most of the drug composition. Excipients are designed to interact with and enhance the properties of APIs. Excipients have various functions. In addition to acting as carriers, and improving stability, pharmaceutical excipients are also conducive in ...
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Application of Flow Cytometry in the Pharmaceutical Industry
Flow cytometry (FC) is an important tool for analyzing complex pathways and responses of single cells, which can track cell phenotypes and functions in multiple dimensions. It is also increasingly applied in drug development. FC not only can detect intracellular and extracellular components, but also detect soluble analytes in serum or plasma samples, such as cytokines, drug complexes, or ...
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What Are Sphingolipids?
Structure and metabolism of sphingolipids Recently, more than 300 species of sphingolipids have been identified and characterized as long-chain sheath-like base backbones. Ceramide is the aminoacylation product of sphingosine at the 2-carbon position, which has strong biological activity and is a basic structural unit of sphingolipids. The simplest forms of sphingolipids include phosphoceramides ...
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Some Basic Facts about Forced Degradation Test for Drug Development
Benefits of forced degradation test The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions. Provide support for drug safety. When toxicologically relevant impurities are not readily available, toxicological evaluation of samples degraded to a ...
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The Key Factor of Excellent Drug Efficacy: Chemical Structure of Drug
How to keep the drug active and give full play to its therapeutic effect has always been the primary problem to be solved by researchers in the field of pharmacy. It is a very complex process from drug administration to the generation of drug efficacy. Scientists have divided this process into three phases: Pharmaceutical phase, pharmacokinetic phase and pharmacodynamic phase. Only by ensuring ...
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Engineers torque technology to medics
Medical experts and sports scientists are becoming increasingly reliant on engineers as their disciplines become more and more technical. Mark Ingham looks at some of the projects his company, Sensor Technology, has helped behind the scenes. Like most rugby players I took my knees for granted until the day a twisting fall resulted in a torn anterior cruciate ligament. Fortunately these days it ...
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Glycosylation of Fc Fusion Proteins: Insights into its Biological Significance
Fc fusion protein (Fc-Fusion) has a complex and diverse molecular structure, and may contain glycosylation modification sites at amino acid 297 of its Fc fragment and the Fab region of some molecules. Moreover, its biological ligands are structurally diverse, and their glycosylation modifications may also be complex, usually involving multiple N-glycan and O-glycan sites and a large number of ...
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Mitochondrial Proteomics
Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed cell necrosis). In addition, mitochondria are involved in important physiological processes such as tricarboxylic acid cycle, fatty acid and amino acid oxidation, and regulation of calcium ion homeostasis. ...
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