drug release Articles
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A novel, dual acting, soft pellet formulation, combining cushioning and rapid disintegration properties, and their incorporation into tablet formulations containing film-coated drug pellets
This work reports the concept of a novel, dual-acting, 'soft' pellet formulation, which protects film-coated 'hard' pellets during tabletting. The novel 'soft' pellets were designed to both cushion film-coated pellets during tabletting and ensure rapid disintegration of the tablets when in contact with water. The deformability and disintegration properties of these pellets were controlled using ...
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How to Prepare Drug Microcapsules: A Holistic Approach
Microencapsulation technology has revolutionized drug delivery systems, allowing for the protection and controlled release of therapeutic agents. Microcapsules, tiny spherical structures capable of encapsulating drugs, offer numerous advantages in terms of stability, targeted delivery, and improved patient outcomes. In this article, we will delve into the methods involved in preparing drug ...
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The Advantages of Exenatide Microneedle Patch Preparation Technology
The backing layer is prepared with the same polymer solution as the needle tip, and polyvinyl alcohol is used as the backing film-forming material to support the microneedle fractions, so that the backing layer has a tight bond with the microneedle tip, and the backing film and the needle tip can be consistently detached from the mold when the film is uncovered, without the problem of process ...
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Characterisation and controlled drug release from a novel two-phase hydrogel system
In this work, a two-phase hydrogel system was prepared by physically imbedding a xerogel in the core of a cryogel which was freeze thawed. The cryogels were prepared with poly (vinyl alcohol) (PVA) and poly (acrylic acid) (PAA) while the xerogels were prepared by UV polymerisation of 1-vinyl-2-pyrrolidinone (NVP), acrylic acid (AA) and various percentages of ibuprofen sodium salt. Mechanical and ...
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Programmed Drug Release of rhBMP-2 for Bone Healing
Summary: Non-union of bone fractures can cause pain and disabilities. Amongst certain fracture types, in specific age groups, the incidence of non-union is over 8% in the United States and over 3.6% of all fractures in the UK. Fracture non-unions have lifelong consequences and a debilitating impact in patients' life. Bone-grafts, allografts and xenograft are currently used to treat bone ...
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The Function of Drug Coating
Coating refers to the unit operation of applying a layer of outer coating material to the dry surface of the formulation. This coating material not only makes the product easier to identify, but even improves the pharmacokinetic properties of the drug by altering its release: ensuring that the drug reaches its target and provides sufficient concentrations in the body to be maintained for an ...
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What Are the Methods for Preparing Microspheres?
Microspheres play a crucial role in the field of pharmaceuticals, biotechnology, and materials science due to their unique properties and applications. These spherical particles, ranging from a few micrometers to several millimeters in size, have a wide range of uses, including drug delivery systems, cell encapsulation, and as supports for various chemical reactions. Polymeric microspheres, ...
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Microneedle Patch Technologies: Innovations in Drug Delivery
Microneedle patch technologies have revolutionized the field of drug delivery, offering a wide range of advantages over traditional methods. These innovative patches provide a minimally invasive and painless alternative to injections while ensuring precise and controlled drug administration. In this article, we will explore various types of microneedle patch technologies, including ...
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What makes Biodegradable Microspheres ideal for Controlled-release Drug Delivery?
Patient-centric drug development is a divisive concept. Dismissed as a buzzword by some. Adopted extensively by others. It has, nevertheless, gained enormous traction over the last decade. This new approach to treatment incorporates patient perspectives into drug development. A key benefit is the keener focus on convenience and safe drug administration. Traditional approaches, prioritising ...
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Mechanism of Action (MOA) of Disintegrant Excipients in Drug Formulation
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions. Except for insoluble coating materials or broken capsule shells, all solid preparations should pass ...
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Liposomes in Anti-tumour Drug Carriers
Introduction Chemotherapy with anti-tumor agents is currently one of the most important systemic treatments for cancer. However, direct treatment with drugs lacks specificity and sensitivity and tends to attack normal cells indiscriminately, resulting in side effects. Liposomes, as drug carriers, provide a superior solution for maintaining or enhancing the efficacy of chemotherapy while reducing ...
By BOC Sciences
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New Method to Produce Ring-Opening Metathesis Polymers with Facile Degradability
A team of chemists at MIT has formulated a method to produce polymers that can disintegrate more readily in the body as well as in the environment. A new type of polymer designed by MIT chemists incorporates a special monomer (yellow) that helps the polymers to break down more easily under certain conditions. (Image credit: Demin Liu) A chemical reaction known as ring-opening metathesis ...
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Microneedle Patch Technology: Revolutionizing Drug Delivery
Introduction Advancements in medical technology have led to innovative solutions for various healthcare challenges. One breakthrough is microneedle patch technology, holding immense promise in revolutionizing drug delivery. These patches consist of micron-sized needles that painlessly penetrate the skin's outermost layer, enabling the controlled release of medications or therapeutic agents. In ...
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Spray Drying of polymeric micelles - Case Study
Customer: Technion-Israel Institute of Technology, Haifa, Israel The research focuses on the pharmaceutical nanomaterials science and drug delivery fields, with special interest in biomaterials science, colloidal chemistry (drug and polymer self-assembly), mucoadhesive drug delivery systems, nanomedicine (drug encapsulation, release and targeting). Application: Drying polymeric micelles ...
By BUCHI
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Comparison and Analysis of SMDC, ADC, and DAC
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. What are their similarities and differences? What are their respective advantages? What is the current status of ...
By BOC Sciences
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What is Nanogels and Its Classifications?
Nanogels (NGs), namely nanoscale hydrogel particles, are three-dimensional network systems formed by physical or chemical cross-linking of polymers. Nanogels have received widespread attention in recent years due to their unique properties and potential applications in various fields such as drug delivery, tissue engineering, and diagnostics.Classification of NanogelsAccording to the phase change ...
By BOC Sciences
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Biopharma PEG Provides Multi-arm PEG Derivatives Crosslinked Into Hydrogels
Polyethylene (ethylene glycol) is a hydrophilic polymer that can have a very high water content when cross-linked into a network. Polyethylene glycol (PEG) is a suitable material for biological applications because it does not normally elicit an immune response. Since the 1970s, PEG has been used to modify therapeutic proteins and peptides in order to increase their solubility, reduce their ...
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Eight Excipients for Transdermal Drug Delivery Systems Materials
Transdermal drug delivery systems have gained considerable importance in the pharmaceutical industry due to their convenience, effectiveness, and ease of use. These systems rely on various excipients, which are inactive substances that aid in the delivery and absorption of active drug compounds through the skin. In this article, we will discuss eight important excipients commonly used in ...
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Polymer material in 3D Printing
With its unique manufacturing technology, 3D printing allows us to produce unprecedented types of items. However, the real advantage of 3D printing technology lies in its printing materials. Only by developing more new materials can the application fields of 3D printing technology be expanded. At present, 3D printing materials mainly include engineering plastics, photosensitive resins, rubber ...
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Spray Drying of polymeric micelles - Case Study
“The Nano Spray Dryer B-90 HP shows high potential to investigate innovative nanoparticle types for nanopharmaceuticals and drug delivery, including stabilization of self-assembly nanomaterials such as polymeric micelles.” Customer name Prof. A. Sosnik, Head Laboratory of Pharmaceutical Nanomaterials Science Company / Institution Technion-Israel Institute of Technology, Haifa, ...
By BUCHI
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