drug residues Articles
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Distribution of Oxytetracycline residues in eggs from orally administered hens
Twenty five-week old hens (n = 6) were administered with an oral dose of 75 mg of Oxytetracycline (OTC) hydrochloride per day per head for five consecutive days and its residues in eggs as well as breast, leg and liver tissues were analysed by a high-performance liquid chromatography-ultraviolet visible detection (HPLC-UV) technique. The highest OTC residue concentration in egg white (0.5944 µg ...
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Electrochemical oxidation of tetracycline antibiotics using a Ti/IrO2 anode for wastewater treatment of animal husbandry
In animal husbandry, antibiotics are widely used to treat and prevent diseases or to promote growth. The use of antibiotics for domestic animals enables to promote safety of livestock products and enhance productivity. Tetracycline antibiotics (TCs) are one of the primarily used groups of antibiotics for cattle and swine. However, the unintentional spreading of antibiotics from animal waste to ...
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Analysis of Opioids Using Isotope Dilution with GCMS-TQ8030 GC/MS/MS
Development of methods for analysis of drugs of abuse has become a high priority for both forensic toxicology and law enforcement. The large numbers of individual drugs and new "designer drugs" has made method development for these compounds a significant undertaking. Gas chromatography mass spectrometry (GCMS) has been used extensively for analysis of drug residues and trace-level drugs in ...
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Removal of antibiotics and pharmaceutical residues in water urgent
According to the WHO, antimicrobial resistance (AMR) is one of the greatest threats to health and food safety. It is increasingly evident that antibiotics, resistant micro-organisms, and their resistance genes are spreading invisibly through water. It is important that we tackle AMR effectively in water too. Antibiotics and other medicines will continue to play a key role in our everyday lives, ...
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The pharmaceutical sector commited to technology to reduce the environmental footprint of covid-19
The COVID-19 pandemic seems to have entered its final stage, with fortunately very low numbers, both hospitalized and deceased. Its impact, however, is not limited to the health and social sphere. The massive use of medicines and sanitary material (wipes, gloves or disposable masks) is one of the most devastating side effects of COVID-19 due to its environmental damage when its waste goes to ...
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Ceramic membranes in the pharmaceuticals industry - Case Study
GlaxoSmithKline, the pharmaceuticals giant, cut operating costs at its drugs plant in Worthing UK, by replacing polymer with Star-Sep™ Ceramic Membranes The installation of a Star-Sep™ Ceramic Membrane system was a critical, yet proportionally low-cost component of GlaxoSmithKline’s anti-biotic drug processing system, enabling a multi-million pound investment to be recouped ...
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Understanding Residual DNA Testing and Methods for Detecting Residual DNA
Most biological agents enter the body directly without passing through the gastrointestinal tract, so in addition to biological activity, relevant authorities have very strict requirements on impurities in drugs. Among them, the host cells residual DNA has always been the focus of regulatory agencies because of its special potential safety risks. Although recombinant protein drugs, antibody ...
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Biopharma PEG Supplies PEG Products For Click Chemistry Reactions
What is "click chemistry"? "Click Chemistry", this is a literary name given to this kind of reaction by the Nobel Prize winner K.Burry Sharless, when the cards are put together, "click" (click). Simply put, it is to add two structures to two molecules respectively, and these two structures can be specifically combined to synthesize the required chemical molecules. One of the most famous ...
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CMC Regulatory Considerations for ADCs
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs have been approved worldwide, of which the FDA has approved 13 ADCs for various cancers, including Adcetris®, Kadcyla®, Besponsa®, Mylotarg®, Lumoxiti®, Polivy®, Padcev®, Enhertu ®, Trodelvy® and Blenrep®. As ...
By BOC Sciences
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Liposomes as Drug Delivery Vehicles
Due to the amphiphilic nature of lipids in liposomes, they can serve as candidate vehicles for drug delivery, and liposomes have received more attention than other systems because of their remarkable ability to deliver drugs to their target sites. Advantages of Liposomes as Drug Delivery Vehicles l As drug delivery vehicles, liposomes have low toxicity and immunogenicity, and the high ...
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Design and R&D of Covalent Drugs
For a long time, electrophilic groups have been a minefield in drug development. Therefore, in the classic medicinal chemistry textbooks of the past, it is always recommended to avoid introducing functional groups such as epoxide, acridine and Michael receptor into the structure of drug molecules, because these functional groups are highly reactive and may interact with a wide range of biological ...
By BOC Sciences
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Do Peptide Drugs Need Acylation Blocking at Nα?
The formation of 2,5-diketopiperazine (DKP) with a bicyclic structure is one of the most detrimental side reactions and degradation pathways affecting peptide synthesis. Despite its crucial role as a versatile building block in drug discovery, the formation of DKP reactions is highly undesirable in the production of peptide drugs. DKP formation can occur during the process of peptide drug ...
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