drug resistance Articles
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Application of Whole Plasmid Sequencing in Analyzing Drug Resistance Genes of Klebsiella pneumoniae
Klebsiella pneumoniae is a significant causative agent of hospital- and community-acquired infections, presenting with various clinical manifestations. Notably, the rapid spread of carbapenem-resistant K. pneumoniae (CRKP) has become a global threat, leading to high morbidity and mortality rates. In this context, researchers have employed high-throughput sequencing to investigate drug resistance ...
By CD Genomics
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Survival of multi-drug resistant enteropathogenic
Escherichia coli andSalmonella paratyphi in Vembanadu lake as a function of saltwater barrier along southwest coast of IndiaThe objective of the study was to evaluate the survival response of multi-drug resistant enteropathogenic Escherichia coli and Salmonella paratyphi to the salinity fluctuations induced by a saltwater barrier constructed in Vembanadu lake, which separates the lake into a freshwater dominated southern and brackish water dominated northern part. Therefore, microcosms containing freshwater, ...
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Regulation of abcg2 expression at the 3` untranslated region of its mrna through modulation of transcript stability and protein translation by a putative microrna in the s1 colon cancer cell line
ABCG2 is recognized as an important efflux transporter in clinical pharmacology and is potentially important in resistance to chemotherapeutic drugs. To identify epigenetic mechanisms regulating ABCG2 mRNA expression at its 3' untranslated region (3'UTR), we performed 3' rapid amplification of cDNA ends with the S1 parental colon cancer cell line and its drug-resistant ABCG2-overexpressing ...
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Antigenic variation in plasmodium falciparum: gene organization and regulation of the var multigene family
Plasmodium falciparum imposes an enormous burden upon the developing world, with 300 to 500 million cases and 1 to 2 million deaths per year (94). Despite extensive esearch efforts, development of parasite drug resistance is a growing problem, and an ffective vaccine is still lacking. Individuals living in areas of high P. falciparum ransmission acquire protective immunity to severe ...
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Tuberculosis Treatments - Case Study
Tuberculosis - a deadly disease with a huge global burden Tuberculosis continues to be the most serious cause of death from a single infectious micro-organism. Drug resistant tuberculosis is a particularly insidious manifestation of this disease for which alternative approaches to conventional therapy are required to facilitate treatment. Despite heroic efforts to develop new drugs to treat ...
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Huateng Pharma Develops Intermediates of Carfilzomib For Multiple Myeloma
Carfilzomib, a proteasome inhibitor, is indicated for the treatment of patients with multiple myeloma. Multiple myeloma (multiple myeloma, MM) is a malignant tumor originating from the B cell lineage, characterized by the clonal proliferation of malignant plasma cells in the bone marrow microenvironment, causing fractures and bone marrow failure, and is the second most common blood system ...
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B.C. Poultry Industry Warned to Halt Use of Antibiotic - Puroxi
Level of drug-resistant bacteria spikes in grocery-store chicken The Public Health Agency of Canada is warning B.C. poultry farmers and veterinarians to stop using a bovine antibiotic on chickens. The agency believes the practice is behind a significant spike in drug-resistant Campylobacter bacteria found in chicken tested from grocery stores. The bacteria are resistant to an antibiotic ...
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Bioinformatics Analysis Brings Disease Genomics Research to a Crossroads
Introduction Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ development, and heterogeneity at the single-cell level, among others. We present ...
By CD Genomics
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HAIs during the COVID-19 pandemic
In the thick of the COVID-19 pandemic it is important to remember that multi drug resistant organisms (MDRO’s) and antibiotic resistant organism infections are still occurring - something many in the field call a silent epidemic, now lurking in the shadow of COVID-19. Last month, the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria met virtually for their fall ...
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Development Trends And Potential Challenges of PROTACs
PROTAC technology has been in development for more than 20 years. PROTAC proof-of-concept studies date back to 2001, when Crews' team tested the possibility of artificially induced intracellular protein degradation with a peptide that was too large in molecular weight and required cells to penetrate the peptide to improve cell permeability. The discovery of the first small molecule PROTAC and the ...
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Rationalising fixed dose combinations for tuberculosis and acquired immunodeficiency syndrome therapy
Poorly managed healthcare can be directly attributed to extensive drug regimens. Numerous chronic illnesses and epidemics such as HIV/AIDS and tuberculosis require elaborate drug regimens for efficacious therapeutic outcomes. Various drug delivery systems have been developed to simplify their regimental drug therapy. However, more effective and innovative drug delivery technologies are required ...
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Mechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides
What are Antimicrobial Peptides? Antimicrobial peptides (AMPs) are naturally occurring peptide molecules found in various organisms, including humans, animals, plants, and microorganisms. These peptides play a crucial role in the innate immune system's defense against microbial infections, exhibiting antimicrobial properties that can inhibit the growth or kill bacteria, fungi, viruses, and even ...
By BOC Sciences
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Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in saccharomyces cerevisiae
The study of eukaryotic membrane proteins has been hampered by a paucity of systems that achieve consistent high-level functional protein expression. We report the use of a modified membrane protein hyperexpression system to characterize three classes of fungal membrane proteins (ABC transporters Pdr5p, CaCdr1p, CaCdr2p, CgCdr1p, CgPdh1p, CkAbc1p, and CneMdr1p, the major facilitator superfamily ...
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Prediction of chemotherapeutic response in ovarian cancer with DNA microarray expression profiling
Abstract Ovarian carcinoma is a leading cause of gynecologic cancer death in women. Despite treatment, a large number of women with ovarian cancer eventually relapse and die of the disease. Hence, recurrent ovarian cancer continues to be a therapeutic dilemma, possibly a result of the emergence of drug resistance during relapse. Recent advances in expression genomics enable global transcript ...
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Schistosome Vaccine, Schistoshield - Case Study
Schistosomiasis is a major neglected tropical disease (NTD) of public health concern to a billion people. Currently an estimated 200 million are infected and an additional an estimated 800 million people are at risk of acquiring this disease in 74 countries. The disease carries high morbidity. Revised estimates of disability adjusted life years (DALYs) and recent calculations based on ...
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Multidrug resistance in fungi
One of the major advances serving to define the beginning of the era of modern medicine was the development of penicillin in the early 1940s as the first widely used antibiotic effective against microorganisms (reviewed in reference 111). In what has become an all-too-common trend, antibiotic-resistant isolates emerged soon after the large-scale use of penicillin to treat bacterial infections ...
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Multidrug resistance in fungi
One of the major advances serving to define the beginning of the era of modern medicine was the development of penicillin in the early 1940s as the first widely used antibiotic effective against microorganisms (reviewed in reference 111). In what has become an all-too-common trend, antibiotic-resistant isolates emerged soon after the large-scale use of penicillin to treat bacterial infections ...
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A "miracle" fruit that can enhance the immune response to tumors
The advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy remains a major obstacle limiting its clinical application. The development of drug resistance is associated with multiple factors, including the level of PD-L1 expression in tumor cells, the tumor microenvironment, ...
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Three generations of ADC Nearly a decade of development-PIII
Novel cytotoxic drugs New cytotoxic drugs have been developed to target cancer cells with low antigen expression or resistance to auristatins or maytansinoids. For this purpose, PBD dimers have been developed, which have a molecular structure containing two alkylated imine functional groups capable of forming covalent bonds with DNA.PBD dimers are about 50-100 times more potent than conventional ...
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New structural target against COVID-19
A new structural target for drug development against COVID-19 has been unveiled today by Sibylla Biotech in collaboration with the Italian National Institute of Nuclear Physics (INFN), the University of Trento and University of Perugia.The breakthrough drug discovery strategy pioneered by Sibylla in this study would not only promise to reduce the risk of drug resistance and harmful side effects, ...
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