Drug Safety Articles & Analysis
33 articles found
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes. To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freely ...
Introduction PEGylation, the process of attaching polyethylene glycol (PEG) chains to therapeutic molecules, has become a cornerstone in pharmaceutical development. This technique improves the pharmacokinetic and pharmacodynamic properties of drugs, enhancing their stability, solubility, and circulation time while reducing immunogenicity. Since its first FDA-approved application in 1990 with ...
This diversity allows for the metabolism of a wide range of compounds, influencing the pharmacological effects and toxicity of drugs. Role in Drug Metabolism The role of cytochrome P450 in drug metabolism is two-fold: it can either detoxify drugs or convert them into active metabolites. The metabolic pathways involving CYP ...
Additionally, in silico screening techniques, such as molecular docking, have become invaluable tools in predicting how potential drugs may interact with nuclear receptors at a molecular level. These computational methods can significantly reduce the time and resources needed in the early stages of drug development. ...
Distribution describes the dispersion of the drug throughout the body. This involves assessing how a drug binds to plasma proteins and how it penetrates various tissues. ...
Pharmacokinetics (PK) and pharmacodynamics (PD) are two fundamental pillars in the field of pharmacology and drug development. Understanding their intricate interplay is essential for determining the efficacy and safety of therapeutic compounds. ...
The world of drug development has long been marked by the rigorous assessment of cardiac safety. ...
Researchers can assess cellular responses to injury and test potential therapeutic agents aimed at promoting healing or preventing scarring. Toxicology and Drug Development: HCEC-12 cells are often utilized to evaluate the cytotoxic effects of various compounds on corneal epithelium. This application is fundamental in the development of ophthalmic drugs and ...
Alfa Cytology has introduced its advanced drug development services for brain tumors. Alfa Cytology, celebrated for its cutting-edge biotech solutions and extensive tumor research expertise, has recently introduced brain tumor drug development services, designed to empower researchers in understanding the intricacies and unique challenges associated with brain ...
Medical advancement relies on clinical trials, which are essential for the development of safe and effective innovative treatments. However, the success and general applicability of these treatments heavily depend on the diversity of the participants involved¹?³. This blog explores the importance of achieving data diversity in clinical trials to enhance clinical trial results and ...
While maintaining a close relationship with PK studies, Toxicokinetic studies primarily square on the adverse effects resulting from drug intake or exposure to a toxic substance. Fundamentally, TK studies provide an understanding of the systemic exposure-risk relation and delivery of safety data for the dose-response analysis. ...
The presence of these impurities can affect the efficacy, safety, and stability of drugs. Therefore, the detection and analysis of glycosylation impurities are crucial in ensuring the quality and therapeutic effectiveness of pharmaceutical products.What are Glycosylated Impurities?Glycosylated impurities refer to a kind of glycosylated product formed during the ...
Drug antibody testing is a laboratory testing method specifically designed to evaluate the immune response of the human body to certain drugs. ...
CD can differentiate the different chiral forms (enantiomers) of drugs, which is critical to ensuring drug safety and efficacy.2. Study of Drug and Target Molecule InteractionsCD can be used to analyze the binding mode of drugs to their biological targets (such as proteins, nucleic acids, etc.). This information ...
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, ...
The Role of hERG (IKr, Kv11.1) in Drug Safety Due to its sensitivity to inhibition by various drugs, hERG-related cardiotoxicity has become a significant consideration during drug development. Numerous drugs have been withdrawn from the market due to their inadvertent proclivity to block hERG channels, causing ...
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, ...
Their performance is as follows: (1) Two antigen-binding sites can bind tumor cells and immune cells, redirect immune cells, recruit immune cells to the surroundings of tumor cells, and enhance the killing power of tumors; (2) It can block two different signaling pathways at the same time to enhance cell killing toxicity; (3) Dual antibodies can target tumor cells more specifically, overcome ...
While formulating commonly used preparations, it's vital to examine the compatibility between APIs and excipients to select excipients that do not adversely effects the drug. Solid Dosage Forms Interactions between drug substances and excipients in solid dosage forms involve both physical and chemical interactions. The former can induce changes in the appearance, ...
In the world of pharmaceuticals, developing safe and effective drugs is a complex and time-consuming process. Before a new drug candidate can progress to clinical trials and ultimately reach the market, it needs to undergo rigorous testing in various model systems to assess its efficacy and safety. ...