drug stability Articles
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Key Points of Drug Stability Analysis
The purpose of the stability testing is to investigate how the raw materials or pharmaceutical preparations will change over time under the influence of temperature, humidity, and light, so as to provide a scientific basis for the production, packaging, storage, and transportation conditions of the drug, and to establish the validity period of the drug through the test. In addition to humidity ...
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What Is Drug Stability Analysis? - Basics You Need to Know in Drug Discovery
The basic requirements of pharmaceutical preparations are safety, efficacy, and stability. Drug stability means that a drug product should maintain the same properties and characteristics as it was at the time of production and within the specified time frame. The stability of pharmaceutical preparations directly affects the effectiveness and safety of drugs. Therefore, it is of great ...
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Establishing a Drug Stability Budget During Storage and Transit
In previous blog posts, we have explored the fact that many drugs, vaccines and pharmaceutical products require refrigerated conditions in order to maintain efficacy. We also examined the importance of minimizing temperature excursions during transportation. Establishing a drug stability budget can minimize discards and ensure a quality product is delivered to the end-user. We know that ...
By AKCP
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Micelle vs Liposome
Micelles refer to molecularly ordered aggregates that begin to form in large quantities after the surfactant concentration reaches a certain value in an aqueous solution. In micelles, the hydrophobic groups of surfactant molecules aggregate to form the core of the micelle, and the hydrophilic polar groups form the outer layer of the micelle. Liposomes are an artificial membrane. In the water, the ...
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Eight Excipients for Transdermal Drug Delivery Systems Materials
Transdermal drug delivery systems have gained considerable importance in the pharmaceutical industry due to their convenience, effectiveness, and ease of use. These systems rely on various excipients, which are inactive substances that aid in the delivery and absorption of active drug compounds through the skin. In this article, we will discuss eight important excipients commonly used in ...
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Monitoring Temperature in Medical Refrigerators
Medical Refrigerators are used to store temperature sensitive drugs and vaccines. Many vaccines require storage between 2°C and 8°C. Time spent outside of this temperature range are known as temperature excursions. Vaccines and drugs have something known as a drug stability budget, which is the total amount of time the substance can be kept outside of its recommended storage range. It ...
By AKCP
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Microneedle Patch Technologies: Innovations in Drug Delivery
Microneedle patch technologies have revolutionized the field of drug delivery, offering a wide range of advantages over traditional methods. These innovative patches provide a minimally invasive and painless alternative to injections while ensuring precise and controlled drug administration. In this article, we will explore various types of microneedle patch technologies, including ...
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Understanding API-Excipient Interactions in Pharmaceutical Formulations
Pharmaceutical formulations consist of active pharmaceutical ingredients (APIs) and excipients. Appropriate excipient selection is critical to the final quality of pharmaceutical products. When designing pharmaceutical preparations, the choice of excipients should not only consider the dosage form factors and excipient functions but also the interaction and compatibility between APIs and ...
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Most Commonly Seen Pharmaceutical Excipients: Preservatives, Stabilizers, Suspending Agents, Thickener Excipients, Flavoring Agents
Pharmaceutical excipients play a crucial role in the formulation and production of drugs, supporting their stability, efficacy, and palatability. Among the numerous excipients used in pharmaceutical preparations, preservatives, stabilizers, suspending agents, thickener excipients, and flavoring agents are commonly observed. Understanding their functions and characteristics is essential for ...
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The Difference Between Span 60 and Tween 60
Span 60 Span 60 is referred to as S60, its main chemical composition is dehydrated sorbitol stearate, the appearance is yellowish waxy solid. Span 60 is an excellent oil-in-water emulsifier with wetting and diffusion properties. It can also be used as a fiber post-processing softener to eliminate static electricity on the fiber to improve softness. Span 60 is harmless to the human body, so it is ...
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Regulatory Guidelines for API-Excipient Compatibility Studies
Pharmaceutical excipients have important functions such as serving as carriers, improving drug stability, solubilization and slowing down the drug release. They are important ingredients that may affect the quality, safety, and effectiveness of the preparation. Classified by function and purpose, pharmaceutical excipients can be used in different drug forms, including: Injection, where ...
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Spray Drying of polymeric micelles - Case Study
“The Nano Spray Dryer B-90 HP shows high potential to investigate innovative nanoparticle types for nanopharmaceuticals and drug delivery, including stabilization of self-assembly nanomaterials such as polymeric micelles.” Customer name Prof. A. Sosnik, Head Laboratory of Pharmaceutical Nanomaterials Science Company / Institution Technion-Israel Institute of Technology, Haifa, ...
By BUCHI
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How to Select Excipients in Drug Formulation?
The purpose of formulation development is to ensure that the drug is safe, effective, stable, and convenient to use. If the dosage form is improperly selected and if the prescription and process design are unreasonable, it will have a certain impact on the quality of the drug product, and even affect the drug’s efficacy and safety. Therefore, formulation research occupies a very important ...
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How to Prepare Drug Microcapsules: A Holistic Approach
Microencapsulation technology has revolutionized drug delivery systems, allowing for the protection and controlled release of therapeutic agents. Microcapsules, tiny spherical structures capable of encapsulating drugs, offer numerous advantages in terms of stability, targeted delivery, and improved patient outcomes. In this article, we will delve into the methods involved in preparing drug ...
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Biopharma PEG’s Azide PEG Series for Pharmaceuticals
Biopharma PEG, a leading innovator in polyethylene glycol (PEG) derivatives, proudly introduces its featured Azide PEG series, which can be used in drug development, click chemistry, ADCs (Antibody Drug Conjugates), PROTACs (Proteolysis Targeting Chimeras), and beyond. This Azide PEG features monodispersed PEGs such as N3-PEG4-OH, N3-PEG3-COOH, N3-PEG11-NH2, N3-PEG3-NHS ester, ...
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How Can Liposomes Be Used in Cosmetics?
Liposomes have a phospholipid bilayer structure similar to cell membranes. Liposomes are closed ultramicrospheres, similar to an organelle-free artificial cell (only with cell membranes). The artificially manufactured liposome structure is also very similar to the exosomes and vesicles existing in nature. It is precisely due to this property similar to biofilm that it can be used as an efficient, ...
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How to Choose Pharmaceutical Packaging Materials?
The packaging materials used for pharmaceutical tablets are in direct contact with the pharmaceuticals. Therefore, as a pharmaceutical manufacturer, when selecting packaging materials, it is necessary to understand some properties and characteristics of packaging materials and containers, to ensure the efficacy and quality of medicines. What are the common pharmaceutical packaging materials? ...
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Bioconjugation Strategies for Enhancing Drug Delivery and Therapeutic Efficacy
In recent years, bioconjugation has emerged as a powerful strategy for improving drug delivery and enhancing therapeutic efficacy. By linking drugs to various biological entities, such as proteins, antibodies, nanoparticles, or targeting moieties, bioconjugation enables precise and targeted delivery of therapeutic agents to desired sites. This article aims to provide an overview of different ...
By BOC Sciences
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Understanding the Workflow and Practical Applications of Drug Affinity Responsive Target Stability (DARTS)
Introduction of Drug Affinity Responsive Target Stability (DARTS) Drug target protein identification is an important step in the research and development of new drugs. Drug Affinity Response Target Stability (DARTS) is a technique that can rapidly and directly identify potential target proteins of small molecule drugs. That is, it prevents the target protein from being hydrolyzed by proteases ...
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How to Prepare Nano-vesicles for Encapsulating Protein Drugs?
Nano-vesicles, also known as liposomes, have emerged as promising drug delivery systems due to their unique structure and properties. These tiny spherical lipid bilayers can encapsulate various therapeutic agents, including protein drugs. In this article, we will explore the process of preparing nano-vesicles for encapsulating protein drugs, as well as the advantages of utilizing this innovative ...
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