Drug Supply Chain Integrity Articles & Analysis: Older
8 articles found
Pharmacokinetics (PK) and pharmacodynamics (PD) are two fundamental pillars in the field of pharmacology and drug development. Understanding their intricate interplay is essential for determining the efficacy and safety of therapeutic compounds. When studied in living organisms, this relationship is referred to as in vivo PK/PD, a discipline that provides invaluable insights into drug behavior ...
Kangle anti-brittle capsule: innovative drug carrier based on patented technology In the field of pharmaceutical preparations, capsules are a common drug carrier, and their integrity and stability are crucial to ensure the effectiveness of drugs. However, when faced with some environmental factors, such as high temperature and humidity, traditional capsules are prone to brittle breakage, leading ...
Introduction Microneedles have gained significant attention in recent years due to their potential applications in various fields such as drug delivery, diagnostics, and tissue engineering. The preparation of microneedles requires precise and efficient technologies to achieve desired features such as size, shape, and mechanical strength. This article provides an overview of different ...
Imagine tiny bubbles, smaller than a red blood cell, carrying powerful medicines directly to diseased cells. This isn't science fiction, it's the cutting edge of drug delivery with drug-loaded liposomes. What are liposomes? Liposomes are microscopic spheres made from phospholipids, the same fatty molecules that make up cell membranes. These phospholipids naturally arrange themselves in ...
Microencapsulation technology has revolutionized drug delivery systems, allowing for the protection and controlled release of therapeutic agents. Microcapsules, tiny spherical structures capable of encapsulating drugs, offer numerous advantages in terms of stability, targeted delivery, and improved patient outcomes. In this article, we will delve into the methods involved in preparing drug ...
Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone, time and cost intensive and lack reproducibility in clinical settings. The paper demonstrates how a computational platform integrating ...
When the Drug Quality and Security Act (DQSA) was signed by President Obama on November 27, 2013, advocates hoped that the confusing patchwork of State laws governing drug pedigree and tracing would finally be replaced by a comprehensive solution for the ‘3T’s’ (Transaction History, Transaction Statement, and Transaction Information) of the increasingly complex pharmaceutical ...
While tracking systems have been developed to decrease occurrences and consequences of medication errors in healthcare facilities, there is a growing need for similar systems to monitor drugs that have just entered the market with unknown adverse events. Between 1997 and 2005, the FDA's MedWatch system successfully identified 15 drugs with toxic side-effects; it took an average of 5.9 years for ...