drug testing Articles
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UCT Clean Screen® DAU Cited in Umbilical Cord Drug Testing
Analysis of umbilical cord samples offers forensic toxicologists a method for evaluating maternal drug intake patterns. These matrices may be an uncommon sample for many laboratories, but for those that are tasked with the challenge, solid phase extraction offers the most efficient methodology for the analysis of said compounds. An estimated 5% of expectant mothers use illicit drugs during ...
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Protein PPARd Can Induce Rapid Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
In a new study, researchers from the Icahn School of Medicine at Mount Sinai have developed a reproducible and scalable method to advance the maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), and hPSC-CMs produced by human stem cell lines in the laboratory support myocardial contraction, which will improve methods for disease modeling, regenerative therapy, and drug ...
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Monlab SL uses iPeak+ to obtain rapid results in drug testing
Monlab SL is a company dedicated to the service of the clinical diagnostic laboratory. They are providing a service according to the needs of hospitals, faculties, research centers, and clinical analysis. One of their business units is the marketing of reliable individual and multipanel blood and urine lateral flow tests. Monlab SL was looking for a reader that would analyze their lateral flow ...
By IUL S.A.
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A Bayesian design for phase I cancer therapeutic vaccine trials
Abstract Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage. However, these designs are poorly applicable for the development of cancer therapeutic vaccines because the expected safety concerns for these vaccines are not ...
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Improved 3D Liver Model Could Forever Change Drug Testing – Allevi Author
The liver plays an incredibly important role in the human body by metabolizing drugs and other compounds. Developing accurate in vitro liver models to study is a critical step in better understanding the biological dynamics of our bodies and removing our dependence on animal models. In their recent publication, Allevi authors Marie Cuvellier, Frédéric Ezan, Hugo Oliveira, Sophie ...
By Allevi, Inc.
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What’s a life-saving drug worth? It depends…
The risk? According to Medicinenet.com, only 5 in 5,000 drugs that enter preclinical testing advance to human trials. And only 1 of these 5 drugs ultimately gets approved for sale, which means the chance for a new drug to make it to market is 1 in 5,000. That’s a lot of R&D ...
By Vistex Inc
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Understanding Induced Pluripotent Stem Cell Differentiation and the Role of iPSC Differentiation Kits in Biological Research
Pluripotent stem cells — cells with the ability to differentiate into nearly any cell type in the body, constituting a significant potential for regenerative medicine. Among these, induced Pluripotent Stem Cells (iPSCs), in particular, have garnered substantial interest from the scientific community due to their ability to be produced from adult cells, eliminating the ethical quandaries ...
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The Advantages of Exenatide Microneedle Patch Preparation Technology
The backing layer is prepared with the same polymer solution as the needle tip, and polyvinyl alcohol is used as the backing film-forming material to support the microneedle fractions, so that the backing layer has a tight bond with the microneedle tip, and the backing film and the needle tip can be consistently detached from the mold when the film is uncovered, without the problem of process ...
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Bridging Clinical Research to Real-World Patient Care Through Predictive Analytics
The ability to predict how a clinical trial participant will adhere to their treatment, and even respond to that treatment, has great promise to advance patient-centric clinical research. But, as we look to understand the impact a drug has on patients’ everyday health outside of a research environment, what happens to these unique, predictive findings around dosing and outcomes once a drug ...
By AiCure
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Bio-Ink: Printing the Future of Medicine and Beyond
Bio-ink is a revolutionary material that is rapidly changing the fields of medicine, tissue engineering, and even bioprinting food. This fascinating substance is essentially a type of ink made from living cells and other biocompatible materials that can be used to 3D print complex biological structures. What is Bio-Ink Made Of? The composition of bio-ink can vary depending on the desired ...
By Matexcel
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Some Basic Facts about Forced Degradation Test for Drug Development
Benefits of forced degradation test The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions. Provide support for drug safety. When toxicologically relevant impurities are not readily available, toxicological evaluation of samples degraded to a ...
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Eight Commonly Used Techniques for Drug Analysis
Drug analysis refers to the detection and analysis of ingredients and contents in drugs. Drug analysis and testing involves the study of composition, physical and chemical properties, purity, and the determination of the content of active pharmaceutical ingredients and their preparations, to ensure that the medications are safe, rational, and effective. Drug analysis and testing are very ...
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How to Apply In Vitro DMPK Services to Support Drug Development and ADMET Study
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...
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How to Apply In Vitro DMPK Services to Support Drug Development and ADMET Study
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...
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OneThree’s Workflow for Identifying Synergistic Drug Combinations - Case study
Background OneThree Biotech was born out of the largest precision medicine institute in America with the purpose of decreasing the failure rate of bringing therapeutics to market using biology driven artificial intelligence. Our technology was builtin a lab setting; allowing us to engineer our methodologies around real-world results. While working with major biotech and pharma partners; ...
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Key Points of Drug Stability Analysis
The purpose of the stability testing is to investigate how the raw materials or pharmaceutical preparations will change over time under the influence of temperature, humidity, and light, so as to provide a scientific basis for the production, packaging, storage, and transportation conditions of the drug, and to establish the validity period of the drug through the test. In addition to humidity ...
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How to Choose Pharmaceutical Packaging Materials?
The packaging materials used for pharmaceutical tablets are in direct contact with the pharmaceuticals. Therefore, as a pharmaceutical manufacturer, when selecting packaging materials, it is necessary to understand some properties and characteristics of packaging materials and containers, to ensure the efficacy and quality of medicines. What are the common pharmaceutical packaging materials? ...
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Virtual Screening: Revolutionizing Drug Discovery through Computational Intelligence
In the fast-paced realm of drug discovery, scientists constantly seek innovative approaches to efficiently and cost-effectively identify potential drug candidates. Virtual screening, a breakthrough computational technique, is poised to transform the pharmaceutical industry. In this article, we delve into the world of virtual screening and explore its remarkable potential to revolutionize drug ...
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What Revisions Has U.S. Pharmacopoeia Made to Pharmaceutical Excipients?
Pharmaceutical excipients are natural or synthetic substances formulated together with the active ingredients of the drug, whose purpose is to increase the formulations containing effective active ingredients or endow the active ingredients in the final dosage form with therapeutic effects, such as promoting drug absorption or solubility. Pharmaceutical excipients can also be used in the ...
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Why Water Usage Data is Critical to the Biopharmaceutical Industry
Few sectors are as captive to water requirements and regulations as the biopharmaceutical industry. Water is a critical component in the manufacture of active pharmaceutical ingredients (APIs), life-saving drugs, vaccines, PPE, testing kits and many more products. To gain a clear picture, water for industrial use represents a significant part of global water demand and if nothing is done to ...
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