drug therapy Articles
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Rationalising fixed dose combinations for tuberculosis and acquired immunodeficiency syndrome therapy
Poorly managed healthcare can be directly attributed to extensive drug regimens. Numerous chronic illnesses and epidemics such as HIV/AIDS and tuberculosis require elaborate drug regimens for efficacious therapeutic outcomes. Various drug delivery systems have been developed to simplify their regimental drug therapy. However, more effective and innovative drug delivery technologies are required ...
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Strategies of biotechnology firms towards new, platform technologies
The human therapeutics sector of the biotechnology industry is the subject of a vast body of empirical literature, which attempts to analyse various success and failure factors for participating companies. This paper synthesises the historical trajectory of three current, leading-edge platform biotechnologies, namely the Polymerase Chain Reaction (PCR), combinatorial drug discovery, and gene ...
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Helping Service-Industry Workers in Pain - Vail Resorts - Case Study
An Uncertain Future Kevin, a 48 year old Ski Instructor at Vail Resorts, tore his meniscus in a ski accident in 2017. After having surgery, his knee pain continued to bother him on the job and at home. Worried his career of 29 years might be over, Kevin turned to over-the-counter drugs, physical therapy, and gel injections. When those failed, he wondered if he had to have a second ...
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Artificial Intelligence for New Drug Design
A Technology Platform for Deep-Learning-Based de novo Drug Design Digital tools are a key to shortening the development of active pharmaceutical ingredients and thus market-ready drugs and therapies. Big data and artificial intelligence (AI) can significantly accelerate many processes and make them more efficient. The Paris, Francebased start-up Iktos is developing a proprietary AI technology for ...
By Iktos
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Artificial Intelligence for New Drug Design
Iktos Develops a Technology Platform for Deep Learning-Based de novo Drug Development Digital tools are a key to shortening the development of active pharmaceutical ingredients and thus market-ready drugs and therapies. Big data and artificial intelligence (AI) can significantly accelerate many processes and make them more efficient. The Paris, France-based start-up Iktos is developing a ...
By Iktos
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Bilateral Insufficiency Fractures in an Oncology Patient Treatment with the CurvaFix IM System - Case Study
CASE PRESENTATION A 70-year-old female recently diagnosed with metastatic pancreatic cancer presented with acute new onset of lower back pain. The patient was taking chemotherapy, participating in a drug therapy trial, and had received radiation therapy. There was no history of acute trauma to the pelvic or acetabular region. Magnetic resonance imaging revealed bilateral fragility fractures, with ...
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Schistosome Vaccine, Schistoshield - Case Study
Schistosomiasis is a major neglected tropical disease (NTD) of public health concern to a billion people. Currently an estimated 200 million are infected and an additional an estimated 800 million people are at risk of acquiring this disease in 74 countries. The disease carries high morbidity. Revised estimates of disability adjusted life years (DALYs) and recent calculations based on ...
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The Power of Outcome-Based Pricing
In February of 2019, CEOs and senior executives from seven major pharmaceutical companies met with the Senate Finance Committee about drug pricing. During that meeting, AstraZeneca CEO Pascal Soriot discussed how value-based agreements have the potential to transform how medicines are priced and reimbursed in the U.S., and in doing so, triggered a host of discussions across the industry on the ...
By Vistex Inc
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bit.bio CEO features in Charles River Laboratories Disruptor series
bit.bio CEO Mark Kotter is featured as part of the Disruptor series from Charles River Laboratories (CRL). The series, created by CRL, celebrates the work of their partners, engaging in meaningful conversation about the current state of human health and future of scientific innovation and its impact. Mark discusses bit.bio's software approach to biology and how human cells that are programmed ...
By bit.bio
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Minimally Invasive Stretta Antireflux Procedure Accessible to Millions more Patients
If your doctor says a certain drug or therapy would be beneficial in treating you, your insurance company still needs to agree to pay for it. This can be frustrating for patients and practitioners when they are trying to improve a chronic condition such as GERD or LPR. In order for an insurance company to change their coverage policies, they need to be presented with certain information to ...
By Restech
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Scientists successfully unraveled the lifecycle of HIV
Despite being recently covered by the global epidemic of COVID-19, humanity is still facing an epidemic of another disease, AIDS, with approximately 38 million people living with HIV worldwide, according to UNAIDS. Many people have died as a result of HIV infection since the epidemic began in the 1980s. Researchers from Germany have recently developed a new technique that may be able to ...
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A Review of Therapies For Alzheimer's Disease
Alzheimer's disease (AD) is a progressive, irreversible neurodegenerative disease clinically manifested by cognitive impairment, behavioral abnormalities, and social deficits. It is predicted that by 2050, the number of people 65 and older with dementia in the United States could reach 13.8 million. In China, more than 15.07 million elderly people aged 60 or over suffer from dementia, of which ...
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Unlocking the Possibilities of Customized Ionic Channel Expression Systems
Ionic channels, which are proteins present in the membranes of all living cells, are gaining significant importance in the fields of bio-medicine and biotechnology. They are responsible for the transmission of signals across cell membranes and are instrumental in multiple biological processes. This raises the demand for a systematic mechanism that can control their expression. The customized ...
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Four Novel Drug Delivery Systems You Should Know
In the field of medicine, effectively delivering drugs to the target site in the body is crucial for successful treatment. Over the years, several innovative drug delivery systems have been developed to improve drug efficacy and patient outcomes. In this article, we will discuss four novel drug delivery systems that have shown promising results in recent research. These systems include ...
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Alucent Biomedical Re-Envisioning PAD Treatment with a Natural Vascular Scaffold
Start-up Alucent Biomedical is using a light-activated molecule, delivered via a balloon catheter, to create a natural vascular scaffold in diseased peripheral vessels, with the aim of providing a long-lasting treatment option that maintains patency while leaving nothing behind in the vessel. Alucent Biomedical Inc. is rethinking peripheral artery disease (PAD) treatment with a novel natural ...
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Novel Biomarkers May Help Predict the Susceptibility of a Population to Rheumatoid Arthritis
Genetics (i.e., mutations) are considered to be the main factor predisposing to the etiology of rheumatoid arthritis (RA), but they account for only a few changes in RA disease risk, and in contrast to genetics, the environment may have an important impact on epigenetic properties associated with disease etiology. Recently, in a study published in the journal Scientific Reports entitled ...
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Non–covalent surface integration: optimising a novel technique for preparing targeted polymeric nanoparticles for cancer therapeutics
Targeting anticancer drugs to their specific molecular targets is a major challenge in cancer therapy. However, advances in biomedical and protein engineering have led to novel nanoparticle targeting approaches. In this study, we used a novel non–covalent insertion of a homo–bifunctional spacer for targeted delivery of drugs to various cancer cells. Functionalised blank nanoparticles for antibody ...
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Analytical Approaches and Applications of Whole Exome Sequencing (WES) in Oncology
Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. Among the powerful genetic analysis methods, Whole Exome Sequencing (WES) stands out as a cutting-edge technique that employs sequence capture technology to enrich DNA from the whole exome regions, enabling high-throughput sequencing. WES offers a simpler, more cost-effective, ...
By CD Genomics
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Comparative effect of an immunomodulator Immunoxel (DzhereloT) when used alone or in combination with antiretroviral therapy in drug-naive HIV-infected individuals
Immunomodulating agent Immunoxel (Dzherelo) has been evaluated in 70 HIV-positive individuals divided into three arms: first, control arm, received standard antiretroviral therapy zidovudine/lamivudine/efavirenz (AZT7/3TC/EFV); second-AZT/3TC/EFV+Immunoxel and third, Immunoxel alone, given orally, twice daily. At 32 weeks of follow-up CD4 cell counts increased in all arms, reaching + 102, +190 ...
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Review of ADC Linker and Research Progress
The linker is not only the molecule part of the covalent link between the antibody and the small molecule payload, but also a key element with design properties in targeted drug therapy. The addition of the linker should not induce aggregation and needs to ensure acceptable PK characteristics, while limiting the premature release of the payload in plasma and enabling the effective release of ...
By BOC Sciences
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