Drug Transporter Interactions Articles & Analysis
40 articles found
For example, imbalances in cholesterol transport and metabolism are directly linked to atherosclerosis and heart disease. ...
Introduction PEGylation, the process of attaching polyethylene glycol (PEG) chains to therapeutic molecules, has become a cornerstone in pharmaceutical development. This technique improves the pharmacokinetic and pharmacodynamic properties of drugs, enhancing their stability, solubility, and circulation time while reducing immunogenicity. Since its first FDA-approved application in 1990 with ...
Nitrogen compounds are a crucial aspect of pharmaceutical chemistry, particularly in the development of antibiotics. Their unique chemical properties, including the ability to form multiple hydrogen bonds and engage in various interactions, make them indispensable in the fight against bacterial infections. This article delves into the application of nitrogen compounds in antibiotic research and ...
Understanding the metabolic stability of potential drug candidates is paramount in the realm of pharmaceutical development. S9 metabolic stability assays provide critical insights into how a compound behaves within biological systems, especially concerning its metabolism, stability, and overall pharmacokinetics. At the core of S9 metabolic stability is the S9 fraction, which is a liver extract ...
Introduction Cytochrome P450 (CYP) refers to a family of enzymes that play a fundamental role in the metabolism of various substances within the body, particularly drugs, toxins, and endogenous compounds. These enzymes are crucial for the detoxification processes in the liver and affect the pharmacokinetics of numerous medications. Understanding the function and importance of cytochrome P450 is ...
Nuclear receptors are a class of proteins that play a vital role in cellular communication, gene expression, and overall homeostasis within the body. They act as transcription factors, responding to various stimuli, including hormones, nutrients, and even environmental agents. Due to their crucial roles in physiological and pathological processes, nuclear receptors have emerged as significant ...
Pharmacokinetics (PK) and pharmacodynamics (PD) are two fundamental pillars in the field of pharmacology and drug development. Understanding their intricate interplay is essential for determining the efficacy and safety of therapeutic compounds. When studied in living organisms, this relationship is referred to as in vivo PK/PD, a discipline that provides invaluable insights into drug behavior ...
Antibody drugs are a type of drugs that treat diseases through artificially synthesized antibodies, which bind specifically to target molecules for therapeutic purposes. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates, etc. Antibody drugs have shown significant therapeutic effects in the ...
FcRn is widely involved in various biological and immune processes in the body, playing roles in immune protection, maintaining the stability of IgG, transmembrane transport, and mother-infant transmission. Utilizing these characteristics of FcRn can help optimize the design of recombinant protein drugs, improving the stability, durability, efficacy, and safety ...
The scientific realm behind the development and evaluation of therapeutic drugs, pesticides, industrial and environmental chemicals profoundly relies on a field of research called Pharmacokinetic/Toxicokinetic (PK/TK) studies. These investigations provide substantial information on how an organism affects a substance, delineating vital zones of absorption, distribution, metabolism, and excretion. ...
In recent years, the field of biotechnology has seen groundbreaking advancements, with the integration of artificial intelligence (AI) into gene editing and therapy. AI-driven technologies have transformed the way we approach genetic modification and treatment, offering unprecedented opportunities for precision medicine and therapeutic interventions. One of the most significant applications of ...
At the same time, with high-throughput sequencing technology, protein interaction relationships can be explored at the whole genome level.ApplicationsPPI-Seq is instrumental in elucidating various biological processes within cells, such as signal transduction, gene regulation, and material transport. ...
In recent years, the field of biotechnology has seen groundbreaking advancements, with the integration of artificial intelligence (AI) into gene editing and therapy. AI-driven technologies have transformed the way we approach genetic modification and treatment, offering unprecedented opportunities for precision medicine and therapeutic interventions. One of the most significant applications of ...
In the vast realm of drug discovery, the fusion of computational prowess and intricate molecular details has given birth to the revolutionary field of protein-small molecule docking. This innovative computational method delves deep into the complex molecular interactions between proteins and small molecules, paving the way for breakthrough advancements in therapeutic approaches and the era of ...
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...
Introduction In the world of molecular interactions, understanding the forces that drive binding events is crucial for advancing scientific research and developing new therapies. One powerful technique that has revolutionized the study of molecular interactions is Microscale Thermophoresis (MST). In this blog post, we will delve into the world of microscale thermophoresis, exploring its ...
For a long time, the research and development of each new drug has faced the challenges of high cost and long cycle. In response to these challenges, major pharmaceutical companies have shifted from targeting common diseases to developing drugs for specific diseases. At the same time, these companies are constantly looking for new technologies for new drug development, such as high-throughput ...
Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since these cells mimic the properties of the liver, researchers can evaluate the ...
Imagine tiny spheres, smaller than a red blood cell, glowing as they navigate the labyrinthine corridors of the human body. These aren't fireflies, they're fluorescent liposomes, a cutting-edge tool in the world of drug delivery and biomedical research. What are liposomes? Liposomes are microscopic bubbles made from phospholipids, the same fatty molecules that make up cell membranes. These ...
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...