drug treatment Articles
-
Artemisinin 90 MHz - Case Study
Artemisinin Artemisinin is a widely used drug in the standard treatment of malaria. It is extracted from the plant Artemisia annua, sweet wormwood, but can also be produced in a semi-synthetic fashion. Figure 1 shows the 1H NMR spectrum of a 250 mM Artemisinin sample in CDCl3 measured in a single scan taking 10 seconds to ...
-
Schistosome Vaccine, Schistoshield - Case Study
Schistosomiasis is a major neglected tropical disease (NTD) of public health concern to a billion people. Currently an estimated 200 million are infected and an additional an estimated 800 million people are at risk of acquiring this disease in 74 countries. The disease carries high morbidity. Revised estimates of disability adjusted life years (DALYs) and recent calculations based on ...
-
Brinkmanship and compulsory licensing policy lessons from Brazil
Approximately 660,000 Brazilians were living with HIV/AIDS in 2003, with an adult prevalence of 0.7%. Brazil currently provides free antiretroviral (ARV) treatment for 158,000 people, which is 40% of the total people on free ARV treatment globally. Brazil also produces 8 out of the 14 drugs required for its national AIDS treatment programme. In an increasingly restrictive Trade-Related Aspects of ...
-
Nanodrug potential in cancer therapy: efficacy/toxicity studies in cancer cells
The interest of nanotechnology to find a more effective approach for drug delivery is growing fast. Nanoparticles as drug vehicles potentially improve the pharmacokinetic and pharmacodynamic properties of various types of drugs, and provide a tool to visualise molecules and tumour target cells that otherwise cannot be detected through conventional imaging. However, there are many aspects of ...
-
Project - Sublingual Exenatide
Liraglutide and exenatide are both belonging to the class of diabetes products called GLP-1 analogues. The GLP-1 analogues have established themselves in the past years as one of the superior drug classes for treatment of diabetes type II in terms of blood glucose lowering and weight loss. Because of the latter, they are being used more and more also in the treatment of obesity. Until now, both ...
By BioLingus AG
-
Demographic projections of future pharmaceutical consumption in the Netherlands
Over the next few decades, many Western European countries will undergo a large demographic transformation introduced by the retirement of the "baby boomers" and the possibility of striking increases in longevity. The aim of this study was to estimate the effect of a growing and ageing Dutch population on the future consumption of pharmaceuticals, so as to be able to anticipate the potential ...
-
Parkinson`s disease therapy: tailoring choices for early and late disease, young and old patients
Abstract Advances in the understanding of basal ganglia circuitry and its altered function in disease states such as Parkinson's disease (PD), coupled with new insights into the mechanisms of cell death and new findings from therapeutic clinical trials, are being translated into clinical practice. Although levodopa (L-Dopa) remains the most effective drug in the symptomatic treatment of PD, ...
By Sensidose AB
-
Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding
Broad-spectrum matrix metalloproteinase (MMP) inhibitors (MMPI) were unsuccessful in cancer clinical trials, partly due to side effects resulting from limited knowledge of the full repertoire of MMP substrates, termed the substrate degradome, and hence the in vivo functions of MMPs. To gain further insight into the degradome of MMP-14 (membrane type 1 MMP) an MMPI, prinomastat (drug code AG3340), ...
-
Diabetic Patient Receives Stem Cell Therapy
In a pioneering “off-the-shelf ” drug treatment in place of a surgical procedure, Maruti Hospital on Tuesday inaugurated its Regenerative Medicine Department by administering stem cell therapy for a diabetic patient who lost four toes on both feet. Developed by pharma major, Cipla, in collaboration with Bengaluru-based, Stempeutics Research, over 14 years, it is available (on order) ...
-
New and dangerous mold
Cryptococcus gattii was considered to be a mold found only in semi tropical and topical climates until it was found recently in the Pacific Northwest. It seems to have adapted to the cool, wet environment on Vancouver Island, Canada and spread from there to western Canada, Washington (state) and Oregon. It may have already spread to Idaho and California. Normally, Cryptococcus molds are capable ...
-
A Review of Therapies For Alzheimer's Disease
Alzheimer's disease (AD) is a progressive, irreversible neurodegenerative disease clinically manifested by cognitive impairment, behavioral abnormalities, and social deficits. It is predicted that by 2050, the number of people 65 and older with dementia in the United States could reach 13.8 million. In China, more than 15.07 million elderly people aged 60 or over suffer from dementia, of which ...
-
The Effects of Excipients on Pharmaceutical Preparation
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more ...
-
The Effects of Excipients on Pharmaceutical Preparations in Drug Design
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more ...
-
Gold nanoparticle–based platforms as cancer–targeted molecules delivery systems
Cancer is a major cause of deaths. More recently, drug delivery systems (DDSs) using gold nanoparticles (GNPs) have been widely developed in cancer therapy for their easily synthesised, functionalised, better biocompatible, and low toxicity properties. Gold nanoparticle–based platforms as cancer–targeted molecules delivery to tumour tissues have been proposed as an effective strategy by ...
-
Three Methods for Virtual Screening
Various calculations are encompassed in the basic experiments related to drug discovery and preparation, such as the calculation of excited state, charge density, molecular volume and so on. One of the vital and extensively applied computing technologies is virtual screening, which is abbreviated as VS. By utilizing this technology, researchers can search the library of small molecules, thus ...
-
Huateng Pharma Supplies Minoxidil Intermediate 2,4-Diamino-6-chloropyrimidine (CAS NO.156-83-2)
Minoxidil was first introduced by Upjohn Company of the United States, and was first used as an oral drug for the treatment of refractory hypertension in the 1970s. In later clinical applications, doctors observed hair regrowth and generalized excessive hair in balding patients, which led to the development of minoxidil preparations. Minoxidil can increase local blood supply, stimulate the ...
-
The Power of Outcome-Based Pricing
In February of 2019, CEOs and senior executives from seven major pharmaceutical companies met with the Senate Finance Committee about drug pricing. During that meeting, AstraZeneca CEO Pascal Soriot discussed how value-based agreements have the potential to transform how medicines are priced and reimbursed in the U.S., and in doing so, triggered a host of discussions across the industry on the ...
By Vistex Inc
-
Hoffmann-La Roche - Ozone oxidation for the elimination of active pharmaceutical ingredients from wastewater - Case Study
Hoffmann-La Roche has set up a new facility in Toluca, Mexico for the production of two highly effective cancer treatment drugs. The wastewater generated in this context poses an ecotoxicological risk. Therefore, it needs to be eliminated at the source. Various methods were tested and evaluated from an ecological and economic perspective. According to preliminary studies, the best way to ...
-
What price health?
When it comes to health care, the balance between cost and effectiveness is a difficult one to strike. The injection of $1.1 billion into the US system therefore needs to produce sustainable results. A middle-aged man appears in a US emergency room complaining of chest pains. Tests show that an arterial blockage is starving his heart of oxygen. He could have treatment A, or treatment B. Which ...
-
Analysis of Differential Gene Expression (DGE) in RNA Sequencing
What are Differentially Expressed Genes (DEGs) in Genetics? Differentially Expressed Genes (DEGs) are genes that exhibit significant differences in expression levels between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process through which the information encoded in a gene's DNA sequence is transformed into functional proteins ...
By CD Genomics
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you