drug use Articles
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Quinine 90 MHz - Case Study
Quinine Quinine is a drug used to treat a variety of conditions, most notably malaria. It is listed as one of the WHO’s (World Health Organization’s) “Essential Medicines”. Figure 1 shows the 1H NMR spectrum of a 250 mM Quinine in CDCl3 measured in a single scan taking 10 seconds to ...
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Abalone conservation in the presence of drug use and corruption: implications for its management in South Africa
The illegal exploitation of wild abalone in South Africa has been escalating since 1994, despite increased enforcement, leading to collapse in some sections of its range. South Africa banned all wild abalone fishing in 2008 but controversially reopened the fishery in 2010. This paper formulates a poacher's model, taking into account the realities of the abalone terrain in South Africa - the ...
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A comparative study of prescribing and transcribing between the women hospital pharmacy and the ASHP: a benchmark approach
The aim of this case study is to compare the performance of the Pharmacy Department in the Women Hospital of the Hamad Hospital Corporation (HMC) of Qatar, with that of the American Society of Health System Pharmacists (ASHP) national survey in terms of prescribing and transcribing of drugs that was conducted in 2001. The methods used in this case study include observation, secondary data ...
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America`s Painkiller Epidemic and What You Can Do
A new study conducted by the National Safety Council (NSC), along with Indiana’s attorney general has found that 80% of Indiana employers have been impacted by prescription drug misuse and abuse by employees. 80% is a substantial figure, causing some to refer to this trend as a painkiller epidemic. This figure is not unique to Indiana, the NSC notes that the results would likely be ...
By SafetyNow
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Artemisinin 90 MHz - Case Study
Artemisinin Artemisinin is a widely used drug in the standard treatment of malaria. It is extracted from the plant Artemisia annua, sweet wormwood, but can also be produced in a semi-synthetic fashion. Figure 1 shows the 1H NMR spectrum of a 250 mM Artemisinin sample in CDCl3 measured in a single scan taking 10 seconds to ...
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Drug adherence in Parkinson`s disease
Abstract Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor ...
By Sensidose AB
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Analysisof alendronicacidin pharmaceutical formulations
Alendronic acid or Alendronate Sodium is a bisphosphonate drug that inhibits osteoclast-mediated bone resorption. Biphosphates work by binding to the bone and preventing calcium from being removed by osteoclasts. This drug is used to prevent and treat osteoporosis as well as several other bone diseases. Alendronate Sodium is sold as tablets or solutions, alone or in combination with Vitamin D. ...
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Getting an insight in the determinants of new product introductions of US biopharmaceutical start-ups
This paper analyses which organisational and industrial factors influence the chance that a US biopharmaceutical start-up is able to introduce a new drug on the US market. Specific attention is paid to the critical mass a biotech company should obtain to improve its chances of bringing a new drug to the market. In the same vein, the economies of scale in R&D are taken into consideration. Second, ...
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UCT Clean Screen® DAU Cited in Umbilical Cord Drug Testing
Analysis of umbilical cord samples offers forensic toxicologists a method for evaluating maternal drug intake patterns. These matrices may be an uncommon sample for many laboratories, but for those that are tasked with the challenge, solid phase extraction offers the most efficient methodology for the analysis of said compounds. An estimated 5% of expectant mothers use illicit drugs during ...
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Innovative technology of engineering magnetic DNA nanoparticles for gene therapy
The present research study is a novel innovation materials technology to engineer magnetic DNA nanoparticles for gene therapy and to enhance the localisation and gene expression of a plasmid DNA via magnetic DNA nanoparticles. Spermine (Sm) was chemically introduced to the hydroxyl groups of dextran, a polysaccharide, to obtain cationised dextran (dextran-Sm). When Fe2+ solution was added to the ...
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Chloroquine diphosphate
Chloroquine (diphosphate) is an antimalarial and anti-inflammatory drug widely used to treat malaria and rheumatoid arthritis. Chloroquine is an inhibitor of autophagy and toll-like receptors (TLRs). MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and ...
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Key points to succeed in Artificial Intelligence drug discovery projects
Abstract Drug discovery and development is an expensive, complex, and time-consuming task [5]. Recently, the development of artificial intelligence (AI) approaches to drug discovery, specifically de novo drug design through the use of deep generative models, has triggered a lot of interest in the drug hunter community, especially as an important tool to speed up the process ...
By Iktos
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California Prop65 list
1. Tetrahydrocannabinol (THC) Tetrahydrocannabinol (THC) is an active ingredient in Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom since 2010 as a mouth spray for people with multiple sclerosis to reduce neuropathic pain, spasticity, overactive bladder, and other symptoms. Nabiximols (as Sativex) is available as a prescription drug in ...
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ADCs Customized Linkers
Antibody Drug Conjugates (ADCs) use targeting ability of monoclonal antibodies to deliver potent cytototoxic payloads to their intended target. The linker encompasses a conjugating functionality suitable for attachment to the antibody, a spacer unit that typically incorporates a hydrophilic element and a trigger which releases the potent cytototoxic warhead. The properties that an optimal linker ...
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The Function of Drug Coating
Coating refers to the unit operation of applying a layer of outer coating material to the dry surface of the formulation. This coating material not only makes the product easier to identify, but even improves the pharmacokinetic properties of the drug by altering its release: ensuring that the drug reaches its target and provides sufficient concentrations in the body to be maintained for an ...
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Leadership for Results in tackling HIV/AIDS
Integral sustainability theory is evident in the UN’s approach to tackling HIV/AIDS in various locations around the world. The approach focuses on a range of change activities that reference a multi-dimensional view of the issue. Business insight HIV/AIDS is a global epidemic but is most acute in some of the poorest regions on earth. It is compounded by a range of issues including ...
By Article 13
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Painting the Picture of Recursion
I’m Anne Carpenter, a member of Recursion’s Scientific Advisory Board since 2014, a few months after the company was launched. I read Chris’ blog post reflecting on Recursion’s early days and thought I could tell my side of the story: watching Recursion get off the ground. I feel a bit sheepish as I recall grilling Recursion co-founders Chris Gibson and Blake ...
By Recursion
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Antibody Selection for ADC Drugs
Antibodies are the precise guidance components of ADCs. In theory, molecules that bring effector molecules to the surface of tumor cells can play the role of antibody guidance The choice of antibody for ADC drugs depends on the target of the disease. Targets can be divided into tumor-specific antigens (TSA) and tumor-associated antigens (TAA) according to their expression. Antigens that are only ...
By BOC Sciences
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Implementation of FDA’s new antibiotic rules
On Wednesday, December 11, 2013, the U.S. Food and Drug Administration (FDA) announced two coordinated actions based on its belief “that production use indications such as ‘increased rate of rate of weight gain’ or ‘improved feed efficiency’ are no longer appropriate for the approved conditions for medically important antimicrobial drugs.” First, it released ...
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Nanopharmaceuticals I: nanocarrier systems in drug delivery
To achieve maximum pharmacological effects with minimum side effects of drugs, drugs should be delivered to target sites without significant distribution to non-target areas. Using pharmaceutical nanocarrier systems for drug delivery is a useful delivery platform for improving target specificity, therapeutic activity, and reducing toxicity of drugs. Various sophisticated nanocarrier systems have ...
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