endocrine activity Articles
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Assessment of multiple hormonal activities in wastewater at different stages of treatment
Changes in the endocrine potency of municipal wastewater at 3 wastewater treatment plants (WWTPs) in Australia were investigated using a panel of in vitro receptor‐driven transactivation assays. The assays were based on human estrogen receptor α, androgen receptor, progesterone receptor, glucocorticoid receptor, and peroxisome proliferator‐activated receptor γ2. Total removal efficiencies for ...
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Pharmaceuticals and other anthropogenic tracers in surface water: A randomized survey of 50 Minnesota lakes
Water from 50 randomly selected lakes across Minnesota, USA, was analyzed for pharmaceuticals, personal care products, hormones, and other commercial or industrial chemicals in conjunction with the US Environmental Protection Agency's 2012 National Lakes Assessment. Thirty‐eight of the 125 chemicals analyzed were detected at least once, all at parts per trillion concentrations. The most widely ...
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Short term fish reproduction assays with methyl tertiary butyl ether (MTBE) with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity
This paper reports on short‐term fish reproduction assays in zebrafish and fathead minnow conducted to examine the potential for methyl tertiary butyl ether (MTBE) to cause effects on the endocrine system. Both studies were performed under Good Laboratory Practice and in accordance with OECD and USEPA test guidelines. Results of the first study demonstrated that exposure to a high test ...
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Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems
The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing using data from in vitro high‐throughput assays for specific ...
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Removal of Active Pharmaceutical Ingredients via Nyex Rosalox
Removal of API’s, EC’s & EDC’s via Nyex Rosalox™ Technology We recently discussed the removal of active pharmaceutical ingredients (API’s) and emerging contaminants (EC’s) in the environment – see Removal of Active Pharmaceutical Ingredients from Water . Endocrine Disrupting Chemicals (EDCs) is another category of compounds whose presence in the ...
By Coftec
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A computational approach predicting CYP450 metabolism and estrogenic activity of an endocrine disrupting compound (PCB‐30)
Endocrine disrupting chemicals (EDCs) influence growth and development through interactions with the hormone system, often through binding to hormone receptors such as the estrogen receptor. Computational methods can predict EDC activity of unmodified compounds, but approaches predicting activity following metabolism are lacking. This study uses a well‐known environmental contaminant, PCB‐30 ...
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Sorption and toxicity reduction of pharmaceutically active compounds and endocrine disrupting chemicals in the presence of colloidal humic acid
This study investigated the toxicity changes and sorption of pharmaceuticals and endocrine disrupters in the presence of humic acid (HA). For the sorption experiment, a dead end filtration (DEF) system was used to separate bound and free-form target compounds. An algae growth inhibition test and E-screen assay were conducted to estimate the toxic effect of pharmaceutically active compounds ...
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Modern Wastewater Treatment Solutions in a State-of-the-Art Pharmaceutical Production Environment
From traditional wastewater treatment to zero-discharge strategy Traditional end-of-pipe solutions for dealing with effluents coming out of the production plant have being gradually substituted for an increasingly decentralised approach to treat selected wastewater streams in the most effective and economically sound way. Moreover, additional goals like reducing overall effluent emissions by ...
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