endocrine effect Articles
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Effects of 17α‐ethynylestradiol, fluoxetine and the mixture on life history traits and population growth rates in a freshwater gastropod
Pharmaceutical and personal care products (PPCPs), some of which have endocrine disrupting effects at environmentally relevant concentrations, have been detected in many surface waters. We evaluated the effects of two common endocrine disrupting PPCPs on the life history traits of the snail, Physa pomilia, using a life table response experiment with snails raised in environmentally relevant ...
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The endocrine effects of dietary BDE‐47 exposure, measured across multiple levels of biological organization, in breeding fathead minnows
The goal of the present study was to evaluate the reproductive function of fathead minnows (Pimephales promelas) exposed to brominated diphenyl ether 47 (BDE‐47) at doses lower than used in previous studies. This was accomplished by evaluating the impacts of BDE‐47 exposures across multiple levels of biological organization. Breeding pairs were exposed to BDE‐47 via diet for 21 days during ...
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Metformin exposure at environmentally relevant concentrations causes potential endocrine disruption in adult male fish
Pharmaceuticals and personal care products (PPCPs) are emerging contaminants that have been found ubiquitously in wastewater and surface waters around the world. A major source of these compounds is incomplete metabolism in humans and subsequent excretion in human waste, resulting in discharge into surface waters by wastewater treatment plant (WWTP) effluent. One pharmaceutical found in ...
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Identification of inter‐specific differences in phase II reactions: Determination of metabolites in the urine of 16 mammalian species exposed to environmental pyrene
Inter‐specific differences in xenobiotic metabolism are a key to determining relative sensitivity of animals to xenobiotics. However, information in domesticated livestock, companion animals, and captive and free‐ranging wildlife is incomplete. The present study evaluated inter‐specific differences in phase‐II conjugation using pyrene (PY) as a non‐destructive biomarker of polycyclic aromatic ...
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Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine‐related genes in vitro and in vivo
Perfluorooctane sulfonate (PFOS) is a widespread and persistent chemical in the environment. We investigated the endocrine‐disrupting effects of PFOS using a combination of in vitro and in vivo assays. Reporter gene assays were used to detect receptor‐mediated (anti‐)estrogenic, (anti‐)androgenic, and (anti‐)thyroid hormone activities. The effect of PFOS on steroidogenesis was assessed both at ...
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Endocrine disrupting effect of the UV filter benzophenone‐3 in zebrafish, Danio rerio
The chemical UV filter benzophenone‐3 (BP‐3) is suspected to be an endocrine disruptor based on results from in vitro and in vivo testing. However, studies including endpoints of endocrine adversity are lacking. The present study investigated the potential endocrine disrupting effects of BP‐3 in zebrafish (Danio rerio) in the Fish Sexual Development Test (OECD TG 234) and a 12 day adult male ...
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Endocrine disruption by di‐(2‐ethylhexyl)‐phthalate (DEHP) in Chinese rare minnow (Gobiocypris rarus)
Great concern has been raised over the potential impact of environmental contaminants on fish populations that inhabit in the Three Gorge Reservoir (TGR). In the present study, we investigated the endocrine disrupting effects of di‐(2‐ethylhexyl)‐phthalate (DEHP), on the Chinese rare minnow (Gobiocypris rarus), an endemic fish distributing upstream waters in the Yangtze River. Adult rare ...
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Evaluation of reproductive endocrine status in hornyhead turbot sampled from southern California's urbanized coastal environments
As part of a regionwide collaboration to determine the occurrence of contaminants and biological effects in coastal ecosystems offshore of urban southern California, the present study characterized the reproductive endocrinology of an indigenous flatfish, the hornyhead turbot (Pleuronichthys verticalis), and compared groups sampled from different study sites representing varying degrees of ...
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Characterization of trenbolone acetate and estradiol metabolite excretion profiles in implanted steers
Exogenous growth promoters have been used in United States beef cattle production for over 50 years. The environmental fate and transport of steroid growth promoters suggest potential for endocrine disrupting effects among ecological receptors; however, the initial excretion of steroid metabolites from cattle administered growth promoters has not been well characterized. To better characterize ...
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EU Endocrine Disrupting criteria will have various implications for industry
In this article we examine the legal and political moves to regulate endocrine disruptors over the past 20 years and the most recent developments in this regard… There is growing concern in the EU and worldwide about the negative human health and environmental impacts possibly caused by endocrine disruptors. So, what are endocrine disruptors (ED)? They are chemicals that may interfere ...
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Effects of atrazine on endocrinology and physiology in juvenile barramundi, Lates calcarifer (Bloch)
Exposure to certain environmental contaminants such as agricultural pesticides can alter normal endocrine and reproductive parameters in wild fish populations. Recent studies have found widespread pesticide contamination across the rivers that discharge into the Great Barrier Reef lagoon. Potential impacts on native fish species exposed to known endocrine disrupting chemicals such as atrazine, ...
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Short term fish reproduction assays with methyl tertiary butyl ether (MTBE) with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity
This paper reports on short‐term fish reproduction assays in zebrafish and fathead minnow conducted to examine the potential for methyl tertiary butyl ether (MTBE) to cause effects on the endocrine system. Both studies were performed under Good Laboratory Practice and in accordance with OECD and USEPA test guidelines. Results of the first study demonstrated that exposure to a high test ...
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Implication of microRNA deregulation in the response of vertebrates to endocrine disrupting chemicals
MicroRNAs are recently discovered small regulatory molecules that control messenger RNA (mRNA) translation in plants and animals and have been implicated in a variety of hormone‐related physiological pathways. Estrogens, thyroid hormones, and gonadotropins all are known to act on miRNA abundance to cause major shifts in cellular activity, physiology, and homeostatic control mechanisms. ...
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Integrated coastal effects study: Synthesis of findings
Municipal wastewater discharges constitute a major source of contaminants of emerging concern (CECs) to coastal waters, yet is uncertainty exists regarding their linkage to adverse biological effects such as endocrine disruption. Limited information is available concerning the types and fate of CECs discharged to the Southern California Bight (SCB) from municipal wastewater and their potential ...
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Effects of progesterone and norethindrone on female fathead minnow (Pimephales promelas) steroidogenesis
As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (norethindrone, 168 ± 7.5 ng/L) and endogenous progestogen (progesterone, 34 ± 4.1 ng/L) on steroidogenesis in adult female fathead minnows ...
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Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β‐trenbolone
The aim of the present study was to investigate the effects of the androgenic endocrine disruptor 17β‐trenbolone on the sexual development of zebrafish (Danio rerio) with special emphasis on the question whether adverse outcomes of developmental exposure are reversible or persistent. An exposure scenario including a recovery phase was chosen to assess the potential reversibility of androgenic ...
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Low concentrations of dihydrotestosterone induce female‐to‐male sex reversal in the frog Pelophylax nigromaculatus
Previous studies have demonstrated that some amphibian species can be sex‐reversed by high concentrations of androgens. Little attention has focused on the effects of androgenic endocrine‐disrupting chemicals (EDCs) on amphibians. The present study aimed to investigate the effects of lower concentrations of the androgenic EDC 5α‐dihydrotestosterone (DHT) on gonadal differentiation and ...
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The distributions, removals and estrogenic effects of selected endocrine disrupting chemicals in two drinking water factories in China
The distributions and effects of 31 selected endocrine disrupting chemicals (EDCs) in two drinking water factories were analyzed in this study. The distributions of EDCs were analyzed by solid phase extraction (SPE) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS). The concentrations of these EDCs were from lower than the LOD (limit of detection) to 23.13 ng L − 1 ...
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Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect‐directed analysis
Effect‐directed analysis (EDA) can be useful in identifying and evaluating potential toxic chemicals in matrixes. Previous investigations of extracts of sediments from the upper Danube River in Germany revealed acute nonspecific and mechanism‐specific toxicity as determined by several bioassays. In the present study, EDA was used to further characterize these sediments and identify groups of ...
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