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Gastric Juice Articles & Analysis

4 articles found

Pharmacokinetic Characteristics of Monoclonal Antibody Drugs

Pharmacokinetic Characteristics of Monoclonal Antibody Drugs

The reasons include: 1) Protein is easy to denature in acidic gastric juice; 2) Protein is easily degraded by a large number of hydrolytic enzymes in the gastrointestinal tract; 3) Protein is large and polar, so it is not easily absorbed by gastrointestinal epithelial cells through diffusion. ...

ByCreative Proteomics


Techniques to Enhance Drug Solubility

Techniques to Enhance Drug Solubility

In addition, the company can also provide analytical services, namely solubility analysis, for a variety of dosage forms to explore their dissolution profiles in various solvents, including inorganic solvents with different pH values, organic solvents, simulated intestinal juice or gastric juice, and other ...

ByCD Formulation


Human Intestinal Ecosystem Analysis

Human Intestinal Ecosystem Analysis

The intestinal microecosystem is rich in various compounds secreted by the host, such as glycoproteins, saliva, gastric juice, bile salts and mucus, and consumes about 1.5 kg of amino acids, short-chain fatty acids and dietary fiber from the daily diet and microbial metabolites. ...

ByCreative Proteomics


Impact of luxs and suppressor mutations on the gastrointestinal transit of lactobacillus rhamnosus GG

Impact of luxs and suppressor mutations on the gastrointestinal transit of lactobacillus rhamnosus GG

The genuine luxS mutant CMPG5412 showed drastically reduced persistence in mice, which was related to less survival in simulated gastric juice, indicating that LuxS metabolism is crucial for the gastric stress resistance of L. rhamnosus GG. The suppressor mutations in the other luxS mutant, CMPG5413, appear to compensate for the metabolic defects ...

ByAmerican Society for Microbiology (ASM)

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