Gastro Intestinal Articles & Analysis
78 articles found
In the pharmaceutical industry, excipients play a crucial role in the formulation of medicines. These inactive substances, which are combined with the active pharmaceutical ingredient (API), perform various functions that enhance the effectiveness, stability, and overall performance of drug products. Understanding the common types of excipients is essential for pharmaceutical scientists and ...
In the realm of pharmacology and drug development, the assessment of drug permeability is essential. One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. This assay plays a pivotal role in understanding how drugs are absorbed in the gastrointestinal tract and aids in predicting their bioavailability. Background ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. This assay utilizes Madin-Darby Canine Kidney (MDCK) cells, which are a widely used model for studying intestinal absorption and permeability due to their similarity to human epithelial cells. Importance of the MDCK ...
The advent of organoid technology has transformed biomedical research through the development of 3D models that precisely replicate human organ structures and functions in a physiological context. Creative Bioarray establishes itself as a world leader in life science innovation through its complete range of organoid services that enhance drug discovery, disease modeling, and personalized ...
Hydrogen and methane breath testing (HMBT) is a non-invasive diagnostic tool frequently used to assess small intestinal bacterial overgrowth (SIBO) and carbohydrate malabsorption disorders such as lactose and fructose intolerance. ...
In vitro permeability assay kits play a crucial role in the field of pharmaceutical development, particularly when evaluating the absorption characteristics of drugs. These kits allow scientists and researchers to investigate how compounds permeate biological membranes, which is vital for understanding drug bioavailability. Understanding Permeability Permeability refers to the ability of a ...
Curcumin, a natural compound found in turmeric, has gained attention for its potential health benefits, including anti-inflammatory and antioxidant properties. It has been studied for its ability to support joint health, improve brain function, and reduce the risk of various diseases. However, curcumin's bioavailability – the degree to which it is absorbed and utilized by the body – ...
Bedfont® Scientific Limited hosted an insightful webinar Mastering Gut Health: Understanding SIBO, Carbohydrate Malabsorption, and Accurate Gastrointestinal Investigation. Gastrointestinal Physiologist and Bedfont® Medical Advisory Board member Melissa Dooley, led the discussion and shared valuable information on various gastrointestinal disorders and the importance of not ...
Therapeutic monoclonal antibodies (mAbs) are a class of antibody drugs that are highly uniform and have pharmacological effects against a single epitope obtained through molecular biology. In the process of new drug development, the study of pharmacokinetics is of great significance. The result can be used to guide the screening and development of drugs, and support the evaluation of their ...
ESMO updated its recommendations for NGS in advanced cancers this year, urging broader use of NGS in additional cancer types and the inclusion of tumor-agnostic biomarkers. The ESMO Precision Medicine Working Group (PMWG) first published its recommendations for when to use next-generation sequencing (NGS) in routine practice for patients with metastatic cancers in 20201. At that time, based ...
Bile, a complex fluid produced by the liver and stored in the gallbladder, plays a crucial role in the digestion and absorption of fats, fat-soluble vitamins, and other essential nutrients. Ox bile extract powder, derived from the bile of oxen, is a natural supplement that has garnered significant interest in the scientific and healthcare communities for its versatile physiological functions and ...
In the field of medicine, effectively delivering drugs to the target site in the body is crucial for successful treatment. Over the years, several innovative drug delivery systems have been developed to improve drug efficacy and patient outcomes. In this article, we will discuss four novel drug delivery systems that have shown promising results in recent research. These systems include ...
In the ever-evolving field of surgery, the integration of data and technology has ushered in a new era of surgical training and education, where precision and proficiency are elevated. We recently had the privilege of speaking with Peter Nau, MD, MS, FACS, Clinical Professor of Surgery-Gastrointestinal, Minimally Invasive and Bariatric Surgery, Surgical Director of the Digestive Health Center, ...
Introduction α-Galactosidase, a versatile enzyme, is gaining recognition for its pivotal role in various industries. In this article, we will delve deeper into the scientific underpinnings, applications, and benefits of α-Galactosidase. Our goal is to provide a detailed, informative exploration of this enzyme, grounded in scientific objectivity. α-Galactosidase: An Enzyme at ...
Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. Among the powerful genetic analysis methods, Whole Exome Sequencing (WES) stands out as a cutting-edge technique that employs sequence capture technology to enrich DNA from the whole exome regions, enabling high-throughput sequencing. WES offers a simpler, more cost-effective, ...
Introduction: Ox bile extract powder, derived from ox bile, is a natural product with a wide range of applications. It contains essential components such as bile acids, cholesterol, bilirubin, and fatty acids. Through meticulous preparation processes, it is transformed into a powdered form, enhancing its stability and convenience. Ox bile extract powder exhibits diverse applications in the fields ...
Probiotics are living microorganisms that offer numerous health benefits when consumed in adequate amounts. These beneficial bacteria can be found in various fermented foods such as yogurt, kefir, sauerkraut, and kimchi, as well as in dietary supplements. The term "probiotic" is derived from the Greek words "pro" and "biotic," which mean "for life." Probiotics have gained popularity in recent ...
What is metatranscriptomic sequencing? Metatranscriptomic sequencing provides direct access to culturable and non-culturable microbial transcriptome information by large-scale, high-throughput sequencing of transcripts from all microbial communities in specific environmental samples. Metatranscriptomic sequencing offers an opportunity to randomly sequence mRNAs as a unit for understanding the ...
In the early 20th century, humans discovered vitamins, and then trace elements and minerals. It was only in the mid-1980s that humans realized the importance of enzymes. Nobel Prize in Physiology and Medicine Arthur Kornberg said: "For our lives, we can no longer find other substances as important as enzymes in nature." Enzymes control the entire body, and when enzymes function abnormally is ...
Liposomes are a novel drug delivery system (DDS). They are bimolecular vesicles that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules, such as chemotherapeutic agents, antimicrobial and antiviral drugs, antiparasitic drugs, genetic material, vaccines, therapeutic proteins, ...