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Gastrointestinal Articles & Analysis
92 articles found
Film coatings often use polymers like hydroxypropyl methylcellulose (HPMC) or other enteric coatings to ensure that the drug is released in the desired part of the gastrointestinal tract. Stabilizers: These excipients develop pharmacological formulations' physical and chemical stability. ...
This assay plays a pivotal role in understanding how drugs are absorbed in the gastrointestinal tract and aids in predicting their bioavailability. Background of Caco-2 Cells Caco-2 cells are derived from human colorectal carcinoma and possess characteristics that mimic intestinal epithelial cells. ...
Importance of the MDCK Permeability Assay Drug absorption in the gastrointestinal tract is a significant factor that influences the efficacy of oral medications. ...
· Organoid Disease Modeling – Our models provide a controlled and physiologically relevant setting for studying complex diseases, including cancer, neurological disorders, and gastrointestinal conditions. · Drug Screening & Toxicity Testing – Patient-derived organoids aid in high-throughput drug screening and predictive toxicity evaluations while ...
CH4 production has been linked to slower gastrointestinal motility, contributing to symptoms such as constipation, a common issue in children with IMO. ...
The permeability of compounds is evaluated by measuring the transport across this cell monolayer, providing information on how well a drug might be absorbed in the gastrointestinal tract. PAMPA (Parallel Artificial Membrane Permeability Assay): PAMPA utilizes a synthetic membrane to assess the passive diffusion of drugs. ...
Despite its benefits, curcumin has a major drawback: it is poorly absorbed in the gastrointestinal tract and is quickly metabolized by the liver, leading to diminished effects. ...
Bedfont® Scientific Limited hosted an insightful webinar Mastering Gut Health: Understanding SIBO, Carbohydrate Malabsorption, and Accurate Gastrointestinal Investigation. Gastrointestinal Physiologist and Bedfont® Medical Advisory Board member Melissa Dooley, led the discussion and shared valuable information on various gastrointestinal ...
The reasons include: 1) Protein is easy to denature in acidic gastric juice; 2) Protein is easily degraded by a large number of hydrolytic enzymes in the gastrointestinal tract; 3) Protein is large and polar, so it is not easily absorbed by gastrointestinal epithelial cells through diffusion. ...
ESMO updated its recommendations for NGS in advanced cancers this year, urging broader use of NGS in additional cancer types and the inclusion of tumor-agnostic biomarkers. The ESMO Precision Medicine Working Group (PMWG) first published its recommendations for when to use next-generation sequencing (NGS) in routine practice for patients with metastatic cancers in 20201. At that time, based ...
This antimicrobial function is particularly relevant in the context of digestive health, as an imbalance in gut microbial populations has been linked to various gastrointestinal disorders. Therapeutic Potential of Ox Bile Extract Powder The unique physiological functions of ox bile extract powder have led to its investigation as a potential therapeutic agent in a variety of ...
Trillions of microorganisms live in the gastrointestinal tract, far outnumbering the body's own cells. The intestinal flora is involved in many physiological and pathological processes in the host, including digestion and absorption of food, metabolism of certain nutrients and pharmaceutical compounds, development of host immunity, intestinal inflammatory states, and more. ...
However, these drugs have various side effects, such as adverse reactions in the gastrointestinal tract and skin, as well as the potential to trigger respiratory and urinary tract infections. ...
The advantages of transdermal patches include sustained release, improved patient adherence, and bypassing the gastrointestinal tract. Nanoparticle Development for Drug Delivery System Nanoparticles have emerged as versatile carriers for drug delivery due to their unique properties, such as high surface area, tunable size, and the ability to encapsulate both hydrophilic and ...
Decoding the Significance of Bile Acid Analysis Bile acids, the intricate molecules orchestrating lipid digestion and absorption, provide a window into the functional dynamics of the liver and gastrointestinal system. Bile acid analysis involves the quantification and profiling of these compounds within biological samples such as blood, urine, or feces. ...
However, it poses significant challenges for mRNA delivery due to the susceptibility of mRNA molecules to nucleases and the harsh acidic environment of the gastrointestinal tract. In this regard, researchers at the Georgia State University Center for Diagnostics and Therapeutics prepared LNPs loaded with IL-22 encoding mRNA for oral administration. ...
We recently had the privilege of speaking with Peter Nau, MD, MS, FACS, Clinical Professor of Surgery-Gastrointestinal, Minimally Invasive and Bariatric Surgery, Surgical Director of the Digestive Health Center, and Program Director, Bariatric Fellowship at the University of Iowa. ...
This scientifically recognized process leads to fewer gastrointestinal issues, including gas and bloating. Applications of α-Galactosidase: Uncovering Versatility Food and Beverage Industry: α-Galactosidase is a staple in food processing, primarily used to enhance the nutritional value and digestibility of plant-based foods. ...
CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers. Front Immunol. 2020 Apr 15;11:508. doi: 10.3389/fimmu.2020.00508. ...
Cytokines in Inflammatory Bowel Disease (IBD) IBD, chronic gastrointestinal inflammation encompassing Crohn's disease (CD) and ulcerative colitis (UC), results from imbalanced interactions between mononuclear phagocytes, Foxp3+ Treg cells, B cells, and cytokines from intestinal epithelial cells (IECs) and immune cells. ...