genomic data Articles
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CARIBIAM: Constrained Association Rules using Interactive Biological IncrementAl Mining
This paper analyses annotated genome data by applying a very central data-mining technique known as Association Rule Mining (ARM) with the aim of discovering rules and hypotheses capable of yielding deeper insights into this type of data. In the literature, ARM has been noted for producing an overwhelming number of rules. This work proposes a new technique capable of using domain knowledge in the ...
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Gene.iobio Paper Published in Nature Scientific Reports
We are proud to announce that the gene.iobio paper has been published in Nature Scientific Reports. This tool has been developed at the University of Utah, with significant contribution from Frameshift co-founders. As genomic data is increasingly being used to aid in disease diagnostics, there is a growing need for easy-to-use tools to enable diagnosticians to interpret complex or uncertain ...
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How Mosaic Offers Free Unlimited Genomic Samples
Mosaic allows users to add as much genomic data (CRAM, BAM, VCF) as they want to their Mosaic projects. This is true for paid accounts but surprisingly this is also true for free accounts (if you haven't already you can sign up and go crazy right now). As far as I'm aware, we are the only genomic cloud platform that offers this or perhaps more accurately can offer this. We are able to do this ...
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Microbial Discovery - Case Study
Goal Understanding of Coronavirus (SARS-CoV-2) of interest using whole-genome sequence data from NCBI Solution Loci helps the scientists to understand the Coronavirus at the molecular level with a few click ...
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Back to blog Federated Architecture in Genomics
Genome initiatives spearheaded by burgeoning numbers of data custodians such as Genomics England (GEL), a Lifebit customer, leverage technological advances to amass large volumes of patient data. As a result, data custodians are veritable gold mines of genome data that could transform precision medicine and provide an equitable solution for diverse healthcare requirements. Pharmaceutical ...
By Lifebit
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Delivering a precision medicine programme at scale
The Covid-19 pandemic highlighted the disparity between those who succumbed to severe illness while others remained relatively unaffected, underscoring the urgent need to shift the healthcare industry’s focus from a one-size-fits-all approach to more personalised healthcare. Personalised medicine promises to transform healthcare with treatments tailored to a patient’s unique genetic ...
By Lifebit
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The Danish National Genome Center Partners with Lifebit to Deliver Nationwide Personalised Medicine
The Danish National Genome Center has awarded Lifebit a four-year contract to implement Lifebit’s Federated Trusted Research Environment software, Lifebit CloudOS, within Denmark's national supercomputing center. LONDON, UK - 28 April 2022 – Lifebit, whose leading technology enables secure analysis over sensitive datasets for researchers and interconnects such large patient cohorts ...
By Lifebit
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MRE11 and H2AX biomarkers in the response to low-dose exposure: balance between individual susceptibility to radiosensitivity and to genomic instability
Unrepaired and misrepaired DNA Double-Strand Breaks (DSBs) were shown to be the key events of radiation-induced toxicity (radiosensitivity) and genomic instability (cancer proneness), respectively. We have previously shown that immunofluorescence with ?-H2AX and MRE11 biomarkers may account for unrepaired and misrepaired DSBs for doses higher than 1 Gy. Three radiosensitivity groups had been ...
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CD Genomics Perspective: The Application of RNA-Seq and DNA-Seq in Cancer Research
Clinicians can make better diagnostic and treatment decisions using the data obtained by next-generation sequencing (NGS) technologies. Breast cancers, for example, have typically been diagnosed using mammography, physical exam, and histology. Genetics became more significant after the discoveries of oncogenes and other biomarkers. Today, commercially available microarray-based tests enable more ...
By CD Genomics
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Learn the General Information of Restriction Endonucleases
More than 30 years ago, when people were studying the host-specific restriction-modification phenomenon of bacteriophages, restriction endonucleases were discovered for the first time. Bacteria can resist the invasion of new viruses, and this method of limiting the survival of viruses can be attributed to the restriction enzymes inside the cells that can destroy foreign DNA. The first restriction ...
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Transforming Genomics Through 2022 and Beyond: Spotlight on Brian Longo
A growing number of governments, pharmaceutical companies and research organisations are choosing Lifebit for its secure, cutting-edge platform and visionary team. Lifebit is pleased to spotlight Brian Longo, who has joined as Lifebit’s Executive Strategic Advisor. Responsible for guiding the design and execution of Lifebit’s rapidly scaling operating models and processes, ...
By Lifebit
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CD Genomics Perspective: Introduction to Virus Identification Using RNA Sequencing
RNA sequencing (RNA-Seq) is a high-throughput RNA profiling technique that uses next-generation sequencing (NGS) platforms, and offers accurate abundance estimations over a wide dynamic range. Both high and low expression levels in individual viral RNA sequencing experiments can be determined using a wide dynamic range, which greatly improves analysis efficiency. As a result, RNA-seq has played ...
By CD Genomics
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Rapid determination of escherichia coli o157:h7 lineage types and molecular subtypes by using comparative genomic fingerprinting
In this study, variably absent or present (VAP) regions discovered through comparative genomics experiments were targeted for the development of a rapid, PCR-based method to subtype and fingerprint Escherichia coli O157:H7. Forty-four VAP loci were analyzed for discriminatory power among 79 E. coli O157:H7 strains of 13 phage types (PT). Twenty-three loci were found to maximize resolution ...
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A Computer Scientist`s Quest for Meaningful Work
I was born in a country at the intersection of Europe and the Middle East — both geographically and culturally. Turkey is a beautiful country, and also a challenging one in many aspects. My mom was not able to continue her education after fifth grade because the middle school for girls was miles away from her home. She has always been a big supporter of my education and career. Growing ...
By Recursion
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Bioinformatics Analysis Brings Disease Genomics Research to a Crossroads
Introduction Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ development, and heterogeneity at the single-cell level, among others. We present ...
By CD Genomics
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A Primer in Biological Data Analysis and Visualization
With the development of next-generation sequencing (NGS) technologies and new sequencers, the exponential growth of biological information generated by the scientific community has brought benefits as well as new challenges to researchers. In the era of big data, the field of bioinformatics has made significant progress in the analysis and interpretation of biological data. Therefore, there is a ...
By CD Genomics
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Pan-Genome Analysis: Overview, Workflow, Application and Recent Advances
What is pan-genome? A pan-genome is the sum of all genomic information within a species. With the development of genomic technology, researchers have found that a single reference genome can no longer meet the needs of genomic data analysis, and more and more species, including the human genome, are choosing to construct a pan-genome instead of a single reference genome. Pan-genomes reflect ...
By CD Genomics
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Charles River Partners with Fios Genomics to Provide Bioinformatics Data Analysis Services - Case Study
As the complexity of advanced therapies continues to grow, more data is needed to establish a drug’s mode of action, efficacy, and long-term safety. It’s no wonder, then, that big data is fueling the drive for tomorrow’s therapies. However, most developers lack the in-house capabilities to produce it and/or the expertise to evaluate it. Charles River has created a complete ...
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What is high-throughput detection of gene expression
What Is High-Throughput Detection of Gene Expression? The high-throughput detection of gene expression relies on next generation sequencing technologies to assess the level of expression of all genes in the genome. These technologies have revolutionized transcriptomic research and we are now entering the ultra-high-throughput era of gene expression studies. In this article, we discuss the ...
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Calypso Released on UDN Data
We are excited to announce a beta release of our Calypso tool on the latest Phase II Undiagnosed Diseases Network (UDN) data. This is a project performed in collaboration with the UDN, and we encourage our initial set of UDN investigators to trial this release and provide any feedback, comments, questions or requests to info@frameshit.io. ...
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