genomics Articles
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Enabling knowledge societies in developing countries: the example of genomics
To address the health needs of developing countries, it is necessary to build and strengthen knowledge societies. By using genomics as an example, we aim to demonstrate that creating effective knowledge societies requires transformative steps and concrete mechanisms. We present four transformative steps towards the development of an expansive outlook regarding equity: developing a global state of ...
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A note on recent trends in knowledge creation and appropriation through genomics: a scientometric analysis
Using scientometric methods, this paper examines the impact of investment in the field of "genomics". It reveals that in terms of scientific publications and application for patents, the USA is still in the lead, that Japan has caught up well, and that Europe, while being strong in terms of scientific production, is weak in terms of patent applications. As in some of the other high-tech ...
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The contribution of communication between irradiated cells and between bystander cells to clonogenic survival and genomic instability
Genomic instability is observed during tumorigenic progression, in a fraction of the progeny of cells surviving irradiation, and also in unirradiated, bystander cells. It is unclear whether communication between irradiated cells themselves, or bystander cells themselves contributes to the observed effect. Herein, we restricted communication between cells by plating human lymphoblasts at low ...
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A synoptic survey of the bioethics of human genome research
The authors discuss the wider social and ethical consequences of recent developments in bioinformatics, "DNA fingerprinting", genetic screening, health and insurance and the patenting of life forms. They appraise the ethics of human genome research, including research conducted under the Human Genome Diversity Project (HGDP) - one type of human genome research which specifically ...
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Complexity metrics for ontology based information
An ontology defines technical terms and shows interrelationships between terms for particular application areas. XML-based standards such as OWL and DAML provide mechanisms to produce XML based ontologies. Ontologies are used in service matching and dynamic web service composition, and are heavily used in bioinformatics and genomics to characterise the structure of living things. Our research ...
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Bioinformatics Workflow for Whole Genome Sequencing
Whole genome sequencing (WGS) has the capacity to greatly enhance genomic knowledge and understand mysteries of life by utilizing the most advanced genetic sequencing technologies. WGS can be used for variant calling, genome annotation, phylogenetic analysis, reference genome construction, and more. WGS tries to cover the whole genome, but actually covers 95% of the genome with technical ...
By CD Genomics
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Rhabdovirus-like endogenous viral elements in the genome of Spodoptera frugiperda insect cells are actively transcribed: Implications for adventitious virus detection
Highlights We searched the Sf cell genome and transcriptome for adventitious virus sequences. We found rhabdovirus-like sequences transcribed from the Sf cell genome. The rhabdovirus-like sequences are closely related to Sf-rhabdovirus. Transcribed endogenous viral elements may result in false positive adventitious virus detection. Sequencing and comparing both the genome and transcriptome ...
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Realising the promise of genomics: exploring governance
The tremendous potential of genomics to contribute to significant healthcare innovations in the developing world will not be realised without attention to governance. Governments, industries and citizens will encounter numerous ethical issues in achieving a balance between risk management and the promotion of the benefits of genomics. We need a governance mechanism that maintains a balance ...
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How Mosaic Offers Free Unlimited Genomic Samples
Mosaic allows users to add as much genomic data (CRAM, BAM, VCF) as they want to their Mosaic projects. This is true for paid accounts but surprisingly this is also true for free accounts (if you haven't already you can sign up and go crazy right now). As far as I'm aware, we are the only genomic cloud platform that offers this or perhaps more accurately can offer this. We are able to do this ...
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Al Sandrock notches another post-Biogen role — and it`s taking him right back onto familiar ground
Al Sandrock has landed another post-Biogen gig for this next chapter in his biotech career following the catastrophic collapse of his campaign for Aduhelm. The R&D expert has lined up a board post for Verge Genomics, an AI-powered startup that has its sights set on a drug program for ALS, followed by new work on Parkinson’s — putting the CNS-focused Sandrock right back into a ...
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Homologous Recombination-mediated Genome Editing Service
As a global leader in recombination-mediated genome editing service, Creative Biogene is dedicated to provide a number of services to achieve scientific results faster than ever before. We have a team of passionate and talented scientists who have years of experience and would work closely with you to provide help in reducing your workload while raising the visibility of your research. In ...
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Gene.iobio Paper Published in Nature Scientific Reports
We are proud to announce that the gene.iobio paper has been published in Nature Scientific Reports. This tool has been developed at the University of Utah, with significant contribution from Frameshift co-founders. As genomic data is increasingly being used to aid in disease diagnostics, there is a growing need for easy-to-use tools to enable diagnosticians to interpret complex or uncertain ...
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Molecular identification of a snap-25-like snare protein in paramecium
Using database searches of the completed Paramecium tetraurelia macronuclear genome with the metazoan SNAP-25 homologues, we identified a single 21-kDa Qb/c-SNARE in this ciliated protozoan, named P. tetraurelia SNAP (PtSNAP), containing the characteristic dual heptad repeat SNARE motifs of SNAP-25. The presence of only a single Qb/c class SNARE in P. tetraurelia is surprising in view of the ...
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Molecular phylogenetics of Candida Albicans
Candida albicans is the most frequently encountered among the Candida species ssociated with humans as human commensals and opportunistic pathogens (10, 46). Over many years, this pleomorphic yeast has attracted much research attention; it was the first human fungal pathogen for which the full genome sequence was determined (30). C. lbicans is a diploid species without sexual morphology ...
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Genomics-based drug innovation: visions and commercial viability
This paper tracks the development of genomics between 1990 and 2005 principally within the US context and reviews that development with specific respect to early expectations of genomics-based pharmaceutical innovation, the initial claims made for it, and the realities of its current position. Emphasis is placed on relations between the genomics sector and its larger pharmaceutical and ...
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Mechanisms regulating the protein kinases of saccharomyces cerevisiae
Reversible protein phosphorylation is a ubiquitous posttranslational modification in all ukaryotes. It is critically involved in the regulation of nearly all cellular processes and ignaling pathways. Protein kinases, the enzymes that catalyze the phosphotransfer reaction, constitute one of the largest protein families, accounting for approximately 2% of the genes in any given eukaryotic ...
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Genome wide association studies (GWAS) analysis of karnal bunt resistance in Wheat (Triticum aestivum L.) germplasm collection from Pakistan | JBES 2020
Abstract Karnal bunt (KB) disease is one of the most important challenges posed on of wheat (Triticum aestivum L.) industry of Pakistan because of itsinclusionin quarantine list around the globe. This disease is caused by the fungus Tilletia indica M. (Neovossia indica). It affects the grain quality of wheat and hampers its movement in international market resulting in economic losses. Presence ...
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Non-coding doesn’t ‘translate’ to non-functional when it comes to evolution
What is it that has allowed more “complex” species to evolve from simpler species? The popular notion that the addition of new protein coding genes is responsible for this increased complexity has been challenged over the last decade. It is becoming apparent that, although new proteins certainly are important, the amount of conserved sequence is far greater than can be accounted for ...
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European collaboration in biotechnology: the molecular analysis of genomes
The new area of genome analysis has led to the rapid formation of large, well-funded international projects which are highly collaborative in nature. The research described here aims to improve our understanding of the research collaboration process through case studies of five genome projects. Large genome centres and extensive networks of small laboratories have adopted large-scale automated ...
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Radiation-induced genomic instability: manifestations and mechanisms
There is considerable evidence that delayed death, gene mutations and a variety of chromosomal abnormalities can be demonstrated in cells that are not themselves irradiated but are the progeny of cells exposed to ionising radiation many cell divisions previously. These effects are collectively referred to as radiation-induced genomic instability. At present, we have limited understanding of the ...
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