Genotyping Articles & Analysis: Older
37 articles found
This feat is paramount in confirming the accuracy of gene edits and establishing definitive correlations between genotype and phenotype. Zebrafish genome editing services hand researchers the tools to engineer zebrafish not only with induced specific genetic mutations but also with fluorescent reporters. ...
Tumors are a heterogeneous group of diseases, and it is not surprising that their genotypes are so different that their metabolic phenotypes differ. Even the same tumor shows differences in metabolic phenotype depending on the tumor cells that constitute it. ...
It has been considered that diseases are generally influenced by obtained biological alterations, but it is becoming evident that any phenotype is the result of a complex interplay between genotype, epigenome, and environment. Epigenetics concentrates on pathways that control how and when specific genes are turned on and/or off, while epi-genomics assess epigenetic changes in a ...
This feat is paramount in confirming the accuracy of gene edits and establishing definitive correlations between genotype and phenotype. Zebrafish genome editing services hand researchers the tools to engineer zebrafish not only with induced specific genetic mutations but also with fluorescent reporters. ...
CD Genomics is a world-leading genomics services company that continues to innovate in high throughput sequencing services for the genomics industry, as well as genotyping, bioinformatics, microarrays, and more. The company has recently launched TCR-seq, a powerful service that enables rapid and efficient analysis of T-cell receptor (TCR) diversity and clonality, providing ...
Regulation of gene expression is fundamental to linking genotypes with phenotypes. RNAs shape complex gene expression networks, which drive biological processes. ...
A typical GWA study has four parts: 1) a large number of people with the disease or trait of interest and a suitable control group; 2) DNA isolation, genotyping, and data analysis to ensure high genotyping quality; 3) statistical tests for associations between SNPs that pass quality thresholds and disease/trait; and 4) replication of found associations in a ...
Long amplicon sequencing spans the complete HLA class I and class II gene, allowing for HLA genotyping with high-precise, which enables unambiguous allele segregation without haplotype putative filling. ...
Epigenetic modifications provide a stable mechanism by which cells with the same genotype can regulate their gene expression and exhibit different phenotypes. ...
In addition, SNPs can be used for genotyping, i.e., determining the proportion of each allelic variant combination at each nucleotide position. ...
HLA genotyping bioinformatics solutions are designed to provide reliable, accurate and reproducible results to infer the precise variation in HLAs and to understand the relationship between HLA polymorphisms and the etiopathogenesis of diseases. ...
Unlike earlier studies relying on culturing bacteria from the tissue of cancer, high-throughput sequencing methods have enabled genotyping the microbial ecosystem within cancer tissue from hundreds to thousands of patients in parallel, providing a better overview of the landscape of cancer diseases associated with the human microbiome. ...
Overview Confirm Cas9 mRNA expression With our ready-to-use Cas9 RT-PCR primer set, you can quickly and easily confirm Cas9 expression in cells or in vitro transcription assays. The amplicon for Game 1 is 219 bp and the amplicon for Game 2 2 is 122 bp. These primer sets allow the detection of nuclease Cas9, Nickase Cas9 and double mutant Cas9 at the messenger level. The primer sets are compatible ...
CD Genomics provides the research community with high-quality next-generation sequencing, third-generation sequencing, genotyping, microarray, and population genetics services. CD Genomics has become an influential company in the industry and continues to innovate, keeping up with the forefront of scientific research and leading the latest and most comprehensive genomics ...
” Article highlights include: For the first time, individuals’ complete HLA-genotype and ethnicity were considered for the selection of shared SARS-CoV-2-specific epitopes PolyPEPI-SCoV-2 vaccination will likely elicit multi-antigenic T cell responses in 98% of individuals, independent of ethnicity (unlike the commonly used epitope selection approach based only ...
Details of the study subjects and host genotyping are presented in the Supplementary Methods. Liver histology Liver histology was assessed using the NASH CRN histological scoring system by a single liver pathologist. ...
Multiplex real-time PCR: A guide to application In multiplex real-time PCR (qPCR), scientists amplify two or more target genes in the same reaction, using the same reagent mix. Multiplexing allows scientists to overcome limitations for myriad applications. First and foremost, multiplexing enables scientists to conserve valuable samples used in a quantitative assay, which is especially ...
Genomadix’s FDA-cleared rapid RX CYP2C19 genotyping test was used to personalize antiplatelet therapy with clopidogrel or ticagrelor. ...
This seven-year-long trial was supported by Genomadix’s genotyping technology (Genomadix RX CYP2C19). Though the team at Genomadix was excited by the results of the trial, we wondered what key opinion leaders thought of the results. ...
This trial is relevant to the field of interventional cardiology and the results suggest encouraging outcomes for genotype-guided therapy leading to escalation from Clopidogrel to Ticagrelor in carriers of CYP2C19 loss-of-function mutations, despite the results falling just short of their ambitious endpoint. ...