health nih Articles
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National Institutes of Health – Perinatology Research Branch - Case Study
The Perinatology Research Branch (PRB) is the only Clinical Branch in the Division of Intramural Research (DIR) of the National Institutes of Health (NIH) to focus its research on human pregnancy and unborn children. It is currently housed at the Detroit Medical Center in Detroit, Michigan through a service contract. The Branch has thrived in this environment, earning a national and international ...
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Celdara Medical Receives National Institutes of Health Funding to develop a new CAR T cell platform to treat solid tumors
Celdara Medical, LLC today announced that the National Cancer Institute of the National Institutes of Health (NIH) has awarded a Small Business Innovation Research (SBIR) Phase I award to fund the company’s proof of concept studies on a new platform to improve chimeric antigen receptor (CAR) T cells efficacy to treat solid tumors. Dr. Joana Murad-Mabaera, who leads this effort, stated, ...
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Genomadix’s European Scientific Advisory Board Comments on TAILOR-PCI Results
Genomadix’s European Scientific Advisory Board Comments on TAILOR-PCI Results *The largest genetics-based clinical trial in cardiology history supported by Genomadix’s Precision Medicine technology * The results of the TAILOR-PCI trial (Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response after Percutaneous Coronary Intervention) were recently ...
By Genomadix
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TAILOR-PCI Proves Genotype-guided Antiplatelet Therapy Reduces MACE
TAILOR-PCI was a 7-year 5,300-patient clinical trial of precision medicine for cardiac stent patients, funded by Mayo Clinic and the National Institutes of Health (NIH). Genomadix’s FDA-cleared rapid RX CYP2C19 genotyping test was used to personalize antiplatelet therapy with clopidogrel or ticagrelor. The results were published on August 25, 2020 in the Journal of the American Medical ...
By Genomadix
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Why participants are so important to health research
Health research is very important for improving health care for all. As we mentioned in a previous article, What is Health Research?, this type of research helps medical researchers understand people’s health and how we can make treatments better for everyone. But health research isn’t possible without the contributions of research participants. Research participants are ...
By Evidation
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Achieving CDISC compliance in academia
CDISC compliance is mandatory for clinical trial submissions to the US Food and Drug Administration (FDA) and Pharmaceuticals and Medical Devices Agency (PMDA). The academic world is no exception. In fact, many academic institutions must achieve CDISC compliance in order to be granted funding for clinical research. CDISC standards can seem overwhelming, like a whole new language to be understood ...
By Formedix
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How good air quality and a healthy routine can help you sleep better
The importance of a good night’s rest can’t be overstated. There is a reason why depriving someone of sleep is a form of torture. Humans need regular periods of quality sleep to recharge, process the day’s experiences, file away memories and follow a normal circadian rhythm to regulate the body’s functions. The amount of sleep we need varies with each person and is ...
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A Combination of Ramucirumab Plus Pembrolizumab Lengthened Survival For Some Lung Cancer Patients
A study conducted under the Lung Cancer Master Protocol (Lung-MAP) found that when treated with a combination of ramuzumab (Cyramza) and Keytruda, Patients with advanced NSCLC whose cancer progressed during prior immunotherapy lived significantly longer than when treated with one of the current standard therapies for this cancer. The hazard ratio (80% confidence interval) for overall survival ...
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FluGen Initiates NIH-Funded Trial of M2SR Flu Vaccine; First Study in Adults Up to Age 85
Study will measure immune responses to matched and drifted virus strains in older adults, a population that is most vulnerable to mortality from flu – Topline data expected in 1H 2022 – MADISON, Wis., May 25, 2021 /PRNewswire/ — FluGen, Inc., a clinical-stage vaccine company transforming vaccine efficacy in infectious respiratory diseases, today announced the initiation of the ...
By FluGen, Inc.
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A Paradigm Shift in the Treatment of Venous Thromboembolic Disease
PE is the most common preventable cause of death among hospital patients in the United States. VTE is a leading cause of death and disability worldwide and has the third-highest mortality rate out of any cardiovascular disease, behind myocardial infarctions and stroke. Unlike myocardial infractions and stroke, where mortality has improved considerably, VTE has seen an increase in cases, with no ...
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Bioprocess Automation, Remote Monitoring, and Real-Time Data Capture Underpin Operation Warp Speed’s Push for a COVID-19 Vaccine
Life science companies spanning the globe are striving to quickly develop and commercialize COVID-19 therapeutics and grab the brass ring of a viable, effective, and safe SARS-CoV-2 vaccine. In the United States, pharmaceutical and biotech companies, as well as Contract Development and Manufacturing Organizations (CDMOs), from coast-to-coast are racing to complete clinical trials and forge ...
By Lab Owl
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A Rationally Designed Therapeutic Vaccine for Herpes
Founder and CEO, Agustin Fernand of Rational Vaccines that is developing a vaccine for herpes. There is a pandemic raging across the world – and it has nothing to do with a coronavirus. Approximately 500 million people worldwide suffer from genital herpes. Several billion more have an oral herpes infection. Herpes is a life-altering disease that can lead to chronic pain, blindness, and ...
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RVx201 Herpes Vaccine
RVx201 Herpes Vaccine Description 2022 RVx201 is a first-in-human herpes simplex virus type 2 (HSV-2) live-attenuated therapeutic vaccine modified to be interferon sensitive that destroys the ability of the virus to inhibit immune responses. Produced by Rational Vaccines, Inc., the technology is based on the pioneering research of the late Dr. William Halford, who dedicated over 25 years to ...
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CBD: Perils, Promise and Development for Neuropathic Pain
Cannabidiol, or CBD, is one of several compounds extracted from the cannabis (marijuana) plant. In recent years, CBD has become enormously popular, and its market is believed to be hundreds of millions of dollars. Believers and users of CBD extoll its benefits for inflammation, muscle soreness, pain, anxiety and a whole host of other things, including cancer. It is, however, very understudied. ...
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Summer Travel 2022 - We’re Still In A Pandemic
In the best of times, summer travel can be a challenge, but for summer 2022, travel may be a bit more chaotic as the COVID-19 pandemic moves through unpredictable ups and downs. ...
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Predicting cardiotoxicity with engineered 3D human cardiac tissue models
Cardiovascular safety liabilities caused 52.3 % of 44 marketed data from 1980 to 2011, and cardiovascular disease remains the leading cause of death globally, yet only 8.7% of cardiovascular drugs successfully pass clinical trials. These statistics demonstrate the need to address a patient’s specific genetic make-up and phenotype by adopting a personalized treatment methodology for ...
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