heart kidney Articles
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Mercury and selenium concentrations in skeletal muscle, liver and regions of the heart and kidney in bearded seals from Alaska
Mean concentrations of total mercury [THg] and selenium [TSe] (mass and molar based) were determined for five regions of the heart and two regions of the kidney of bearded seals (Erignathus barbatus) harvested in Alaska in 2010–2011. Mean [THg] and [TSe] of bearded seal liver and skeletal muscle tissues were used for intertissular comparison. Se:Hg molar ratios were used to investigate ...
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Harnessing the utility of autoantibodies to overcome challenges associated with clinical development in Systemic Lupus Erythematosus (SLE)
Overcoming issues of heterogeneity in disease classification and enabling new approaches to successful drug development. SLE is an autoimmune disease with a wide range of clinical manifestations. It affects approximately 5 million people worldwide and its prevalence varies in different geographies. SLE accounts for around 70% of all cases of lupus, other forms being cutaneous lupus, ...
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Bio-Ink: Printing the Future of Medicine and Beyond
Bio-ink is a revolutionary material that is rapidly changing the fields of medicine, tissue engineering, and even bioprinting food. This fascinating substance is essentially a type of ink made from living cells and other biocompatible materials that can be used to 3D print complex biological structures. What is Bio-Ink Made Of? The composition of bio-ink can vary depending on the desired ...
By Matexcel
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Will Metformin Be Replaced By SGLT-2 Inhibitors
Metformin is a classic first-line hypoglycemic agent for patients with type 2 diabetes, and is an essential drug in combination regimenes. However, as the evidence is updated, the idea of drug selection for first-line treatment is changing. GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic management) have also been recommended by multiple ...
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Understanding and Treating Diabetic Neuropathy
What is diabetic neuropathy? The most common complication of diabetes is neuropathy, which is nerve damagecaused by high blood sugar. Most neuropathy affects the legs, hands and feet and usually presents as numbness, pain or tingling. Diabetic neuropathy can also seriously impact the heart, blood vessels, digestive system and the kidneys. Symptoms can range from mild discomfort to extreme pain. ...
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Subacute toxicity of selenium sources in mice
Sixteen groups of mice were fed diets containing different selenium species to compare their toxicity. Inorganic sodium selenate and sodium hydroselenite, elementary nanoSe, organic Sel‐Plex, and Lacto‐MicroSelenium were administered for 14 d at concentrations of 0.5, 5, and 50 ppm Se, equivalent to 0.5, 5, and 50 mg Se/kg food, corresponding to an estimated 4, 40, and 400 µg/kg bw/d Se uptake, ...
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Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease
Follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management — lowering systolic blood pressure to less than 120 mm Hg — dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering ...
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The Importance of Organ Donation
Why should you donate organs? Organ donation is a way to save the lives of people who are sick, not healthy and in need of new organs. When someone’s organs are weak, they require a new one to continue living. Organ donation refers to the supply of a healthy organ, gained from either a living or passed away donor, to help an individual requiring a transplant to improve ...
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COVID-19 Clinical Report for Dead Infected Case
Clinical analysis of 25 novel coronavirus pneumonia deaths:asphyxia due to pulmonary mucus Pengpai news reporter Wu Yi Pengpai news ,February 29 On February 25, MedRxiv published a paper from Wuhan University People's Hospital, Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China. The ...
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What Are the Applications of Enzymes in Disease Research and Treatment?
With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive. 1. The relationship between enzymes and certain diseases The diseases caused by the lack of enzymes in the human body are mostly congenital or ...
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The Functions and Roles of Enzymes
Catalysis Enzymes are a class of biological catalysts. They govern many catalytic processes such as metabolism, nutrition, and energy conversion of organisms. Most of the reactions closely related to life processes are enzyme-catalyzed reactions. These properties of the enzyme enable the intricate process of material metabolism in the cell to proceed in an orderly manner, and to adapt material ...
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Injecting mRNA and generating CAR-T directly in the body to repair the heart in one shot
January 6, 2022—Researchers at the Perelman School of Medicine at the University of Pennsylvania published a research paper in Science titled: CAR-T cells produced in vivo to treat cardiac injury. Heart damage or inflammation can induce fibroblasts to overproduce fibrous material, causing cardiac fibrosis, which hardens the heart muscle and impairs heart function. Heart failure, liver ...
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Overview of Diabetes: Prevalence Assessment, Treatment And Prevention
Diabetes is a chronic disease that affects more than 540 million people worldwide and is one of the leading causes of death and disability worldwide. In China, there are more than 114 million adults with diabetes, accounting for about a quarter of the world's diabetes patients. With the change of living and eating habits, diabetes has become the third major factor affecting human health after ...
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Organoid Models of SARS-CoV-2 Infection learned from COVID-19
The clinical presentation of COVID-19-related illness ranges from asymptomatic to mild respiratory symptoms resembling influenza infection to acute symptoms including pneumonia requiring hospitalization and admission to the intensive care unit. COVID-19 starts in the upper airways and lungs, but in severe cases can also affect the heart, blood vessels, brain, liver, kidneys, and intestines. ...
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What is Sepsis? Key Symptoms, Potential Complications, and Vital Treatment
The term sepsis describes the body's extreme response to infection. When a person suffers from sepsis, his or her immune system has been triggered in response to an infection, which causes inflammation and damages tissues in the body. Symptoms of Sepsis The symptoms of sepsis may include: Fever (102 degrees Fahrenheit or higher) Chills Rapid breathing (above 20 breaths per minute) or ...
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Diabetic Burnout: What is it & how can we help ourselves?
Diabetes is a chronic health condition that affects how your body turns food into energy. Most of the food you eat is broken down into sugar and released into your bloodstream. When your blood sugar goes up, it signals your pancreas to release insulin. Insulin acts like a key turning on cells with sugar as fuel (energy). Diabetes affects your body’s ability to produce or use that insulin. ...
By EO2 Concepts
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Evaluating Microbiome Therapies with Intestinal Cell Models
The microbiome has been shown to play roles in many different disease processes and is implicated in many more, from infectious and gastrointestinal diseases to autoimmune and neurological disorders. Advanced models of the gut leveraging intestinal and colonic stem cells are enabling the development of more reliable and robust systems for evaluating the impact of changes in the microbiome on gut ...
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