hematologic Articles
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Mid-Size Laboratories Can Now Enjoy the Same Efficiency Benefits as Large Facilities with Beckman Coulter’s New Hematology Analyzer
Beckman Coulter , a global leader in clinical diagnostics, today announced the commercial launch of its new DxH 690T hematology analyzer. Designed to help laboratories streamline workflow and maximize uptime, the DxH 690T offers all the benefits of the company’s flagship DxH 900 hematology analyzer to mid-size labs, including an industry-leading 93% first-pass yield and the recently ...
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Traumatic lumbar punctures in diagnostic and intrathecal treatment punctures of pediatric hemato-oncology patients
Extensive study of CSF laboratory analysis records by pediatricians and Injeq’s researchers has been published as an open access article in Pediatric Hematology and Oncology. Traumatic lumbar punctures in diagnostic and intrathecal treatment punctures of pediatric hemato-oncology patients. 2022 April ...
By Injeq Oy
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Protecting hematology patients in Polish regional hospitals - Case Study
Poland has 38 large regional hospitals responsible for hematology and oncology. Genano has delivered a total of over 150 air purifiers to these hospitals. Of the 16 regions in Poland, 13 are using Genano to protect immunocompromised patients. Challenge Polish regional hospitals have recognized the need for protecting patients from infections by providing ultra pure air in patient ...
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Potent anti-tumor activity against patient CLL, MM and AML cells by LAVA-051, a bispecific Vγ9Vδ2-T and type 1 NKT cell engager targeting CD1d
Bispecific antibodies that target tumors by engaging innate-like T cell subsets with inherent antitumor activity Bispecific antibodies that target tumors by engaging innate-like T cell subsets with inherent antitumor activity CD1d can be expressed by several hematologic malignancies Bispecific Vγ9Vδ2-T cell engager Unique ability to also trigger type 1 natural killer T (NKT) ...
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A slide stainer for hematology: IUL’s PolyStainer
Slide staining can be tedious, and guarantee the same standards in quality from the first to the last slide is challenging. To solve this, the automatization of the process can be a solution. However, slide stainers for hematology can be expensive and tricky to use. The haemato-pathologist should ensure a good quality smear, thorough examination, and proper interpretation in line with ...
By IUL S.A.
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Effects of trophic exposure to diclofenac and dexamethasone on hematological parameters and immune response in freshwater fish
The aim of this work was to evaluate the effects of diclofenac and dexamethasone on hematological parameters and immune response in the fish species Hoplias malabaricus after trophic exposure. Fish were fed twice every week with Astyanax sp., which was submitted to intraperitoneal (i.p.) inoculation with diclofenac (0, 0.2, 2.0, or 20.0 µg/Kg) or dexamethasone (0.03, 0.3, or 3.0 µg/Kg). After ...
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Bioimpedance spinal needle provides high success and low complication rate in lumbar punctures of pediatric patients with acute lymphoblastic leukemia
The great results of our latest clinical investigation have now been published as an open access article in Scientific Reports, a respected peer-review journal. Read the article from the journal using the link! Bioimpedance spinal needle provides high success and low complication rate in lumbar punctures of pediatric patients with acute lymphoblastic leukemia. 2022 April 26 Tampere University ...
By Injeq Oy
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Medical Surveillance of Search Dogs Deployed to the World Trade Center and Pentagon: 2001–2006
In response to the terrorist attacks of September 11, 2001, at the World Trade Center and Pentagon, almost 50,000 rescue workers and approximately 300 search and rescue dogs participated in rescue and recovery operations. The dogs were exposed to the same hazards as the human workers, but did not have any of the personal protective gear. This prospective double cohort observational study compared ...
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Subacute toxicity of selenium sources in mice
Sixteen groups of mice were fed diets containing different selenium species to compare their toxicity. Inorganic sodium selenate and sodium hydroselenite, elementary nanoSe, organic Sel‐Plex, and Lacto‐MicroSelenium were administered for 14 d at concentrations of 0.5, 5, and 50 ppm Se, equivalent to 0.5, 5, and 50 mg Se/kg food, corresponding to an estimated 4, 40, and 400 µg/kg bw/d Se uptake, ...
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Natural Killer Cells May Be Scaled and Engineered as a Next Generation, Off-the-Shelf Cell Therapy for Cancer
The advent of immunotherapies for cancer, and more recently of cellular immunotherapies, has substantially altered the treatment landscape. In hematological malignancies, complete response rates to CAR-T cells can exceed 80%. These responses are often durable in nature and have attracted considerable excitement and investment in the development of cell therapies for an expanded range of ...
By Nkarta, Inc.
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Enzyme induction and histopathology elucidate AhR vs. non‐AhR mediated effects of aroclor 1268 in American mink (Neovison vison)
Polychlorinated biphenyl (PCB) concentrations reported in preferred prey and blubber of bottlenose dolphins from the Turtle‐Brunswick River Estuary (TBRE, Georgia, USA) suggests the potential for adverse effects. However, PCBs in TBRE dolphins are primarily derived from Aroclor 1268, and predicting toxic effects of Aroclor 1268 is uncertain due to the mixture's unique composition and ...
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New Study Findings about Glycoprotein PTGDS
Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalcitonin superfamily that plays a dual role in prostaglandin metabolism and lipid transport. PTGDS is involved in various cellular processes including solid tumorigenesis, but its role in tumorigenesis is paradoxical, and the significance of PTGDS in hematologic malignancies is not clear. The aim of this new study was to ...
By CD BioGlyco.
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A three‐generational study of in ovo exposure to PBDE‐99 in the zebra finch
Based on a literature review of avian data for polybrominated diphenyl ethers (PBDEs), ecologically relevant doses, low (10 ng/egg), medium (100 ng/egg), and high (1,000 ng/egg) of the 2,2',4,4',5‐pentabromodiphenyl ether (BDE‐99) congener along with dimethylsulfoxide (DMSO) control were injected into the yolk sac of un‐incubated eggs of zebra finch, Taeniopygia guttata. Offspring development ...
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Tackling Barriers to MRD Adoption in the Community Setting
The day a person receives a cancer diagnosis is likely one of the worst days of their lives. For some new patients, the typical approach may be to seek care from a specialist at an NCCN-designated cancer center. But for the majority of Americans, it will be a community oncologist who guides them through their cancer journey. That’s why Adaptive recently partnered as a sponsor with ...
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Sublethal propoxur toxicity to juvenile common carp (Cyprinus carpio L., 1758): Biochemical, hematological, histopathological, and genotoxicity effects
The sublethal toxicological and genotoxic potential of propoxur, a widely used carbamate insecticide against household pests, in veterinary medicine, and in public health, was evaluated on carp as a model species (Cyprinus carpio L., 1758) using the erythrocyte micronucleus test. Based on the 96‐h lethal concentration, 50% (LC50) data from the U.S. Environmental Protection Agency ECOTOX Database ...
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Multi-Site veterinary diagnostic laboratory uses Matrix Gemini LIMS for Seamless sample management case study
The Matrix Gemini Laboratory Information System (LIMS) from Autoscribe Informatics has been used to co-ordinate sample tracking, management and reporting across four different locations for a busy veterinary diagnostic and clinical pathology laboratory. Background Nationwide Laboratory Services Is a UKAS accredited independent multi-disciplinary veterinary laboratory providing diagnostic and ...
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Celdara Medical Receives National Institutes of Health Funding to develop a new CAR T cell platform to treat solid tumors
Celdara Medical, LLC today announced that the National Cancer Institute of the National Institutes of Health (NIH) has awarded a Small Business Innovation Research (SBIR) Phase I award to fund the company’s proof of concept studies on a new platform to improve chimeric antigen receptor (CAR) T cells efficacy to treat solid tumors. Dr. Joana Murad-Mabaera, who leads this effort, stated, ...
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Detecting Fusion Transcripts by RNA Sequencing in Screening Tumors
What is fusion gene? What is Chimeric RNAs? A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can lead to or promote the development of tumors. For example, in chronic granulocytic leukemia, ...
By CD Genomics
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Animal study results has been be presented by Prof. Bart Meuris during the Heart Valve Society (HVS) Meeting 2021
In-vivo Evaluation Of A Novel Surgical Heart Valve Prosthesis Designed To Be Durable, Anticoagulant-free And Silent. Bart Meuris, Lucas Van Hoof, Wilm Decré, Marie Lamberigts, Tom Langenaeken, Peter Verbrugghe. KU Leuven, Leuven, Belgium. OBJECTIVE: Heart valves prostheses still face limitations: reoperations with tissue valves or lifelong anticoagulation with mechanical valves. The ...
By Novostia SA
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The C-Myc Oncogene Is Associated with Aging, New Study Found
The Myc gene is one of the most important drivers of cancer in mice and humans. Myc also plays a newly discovered key role in aging, according to a new study in Cell Reports by researchers at UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine. The study, led by Edward V. Prochownik, MD, UPMC Children's Hematology/Oncology Division and Paul C. Gaffney ...
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