hepatitis B Articles
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Immobilisation of HEP-1 by covalent attachment to aldehyde–agarose gels
A procedure of covalent multipoint attachment has been performed for immobilisation of HEP-1 using two different pH conditions. This study revealed that in more alkaline media as pH 10 the antibody immobilises quickly. In this condition, supports are able to bind 4 mg of HEP-1 per mL of gel. In order to test the activity of this new immobilised derivative, it was used in the affinity purification ...
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Overview Of SFA Therapeutics
SFA Therapeutics’ CEO Dr Ira Spector presents an overview of the company and its platform technology SFA Overview Presentation on YouTube Introduction to SFA Liver Disease and Oncology Programs. SFA Oncology More information here We received US Patent 10,143,669B2; to prevent Hepatitis B progression to HCC, a liver cancer that affects 400 million patients and causes 1 million cancer ...
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Maintaining Quality in Stem Cell Products: Recent Developments in Regulation (Series Part 1 of 4)
Background Stem cells are naturally occurring cells in the body that have the ability to divide and produce a range of different cell types. They are important in the growth and development of the body as well as repair after injury. The past few years have brought a dramatic increase in the body of knowledge concerning stem cells, and their research and investment into uses in medicines1. ...
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The Role of Probiotics in Cancer Prevention Receives Increasing Attention
Liver cancer is the fifth most common cancer in the world and the third leading cause of cancer deaths. A healthy diet and lifestyle are the key to preventing various diseases. In recent years, probiotics, as part of a healthy diet, have received increasing attention for their role in cancer prevention and treatment, including liver cancer. Do probiotics have the potential to prevent liver ...
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Project - Sublingual Interferon-alfa (BL SLIT II)
We plan to develop sublingual interferon-alfa for the prevention of viral infections, such as influenza and coronaviruses (such as COVID-19). The rise in prevalence of viral respiratory infections in humans and increase in health care expenditure are projected to boost the growth of the global respiratory antiviral treatment market. Respiratory syncytial virus, influenza virus, parainfluenza ...
By BioLingus AG
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Needlestick Injury - the pointy end of a preventable pandemic
The Challenge Every 60 minutes, of every day, six people suffer a needlestick injury somewhere in the world. Every day, 3 people die as a result of those injuries[1]. The World Health Organisation (WHO) reports in the World Health Report 2002, that of the 35 million health-care workers world wide, two million experience percutaneous exposure to infectious diseases each year[2]. WHO estimates ...
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CD Genomics Perspective: Introduction to Virus Identification Using RNA Sequencing
RNA sequencing (RNA-Seq) is a high-throughput RNA profiling technique that uses next-generation sequencing (NGS) platforms, and offers accurate abundance estimations over a wide dynamic range. Both high and low expression levels in individual viral RNA sequencing experiments can be determined using a wide dynamic range, which greatly improves analysis efficiency. As a result, RNA-seq has played ...
By CD Genomics
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Degradation of splicing factor SRSF3 contributes to progressive liver disease
Abstract Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRSF3 is decreased in human liver samples with nonalcoholic fatty liver disease (NAFLD), ...
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Host Cell Residual DNA: Understanding its Significance and Detection Methods
Host Cell Residual DNA (rcDNA) refers to fragments of DNA derived from host cells that may be present in biological products. These products must not contain foreign substances, particularly host DNA, to avoid immune rejection and potential threats to life safety. Regulatory agencies worldwide have imposed strict limits on the amount of rcDNA, and various pharmacopoeias have outlined several ...
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Research Progress on Aluminum Adjuvants and Their Mechanisms of Action
What are Adjuvants? Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response to an antigen. Adjuvants can help antigens induce long-term effective specific immune responses in vivo, leading to higher vaccine efficacy and prolonged protection from immune responses. ...
By BOC Sciences
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Sexually Transmitted Infections and Disease: The Silent Pandemic
Twenty-five years ago, the Institute of Medicine (IOM) published a report on confronting sexually transmitted diseases (STDs) as the “hidden epidemic of tremendous health and economic consequence in the United States, and that the scope, impact, and consequences of STDs are under recognized by the public and in healthcare.”1 Today, the United States is in the midst of a major ...
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Iterations of Portal`s Needle-Free Drug Delivery
Innovations and Iterations In the consumer tech world, iterations happen very fast, though most inventions are not ‘one and done’ masterpieces: the Dyson cyclone vacuum cleaner made 5,127 prototypes. In the medical device world, development takes longer because of the appropriate and necessary regulations and need for safety. Using an agile approach, but with safety and reliability ...
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How pregnant women can protect themselves from COVID-19, flu and other viruses
COVID-19 and viruses are a concern for all of us. Yet, anticipating a virus’s impact on an unborn child has heightened during the coronavirus pandemic for pregnant women or those expecting. However, there are tips you can take to protect yourself from viruses. ...
By Respiray OU
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Temperature Sensitivity of Vaccines
All vaccines are sensitive to extreme heat and extreme cold and require both proper vaccine storage and management to avoid any loss of potency. Immunization is the most effective and economical public health measure against infectious diseases that cause morbidity or mortality. Immunization prevents two to three million deaths every year from diseases such as hepatitis, pertussis (whooping ...
By AKCP
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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or ...
By KoBioLabs
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