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Hepatocellular Carcinoma Articles & Analysis

7 articles found

Peptide Vaccine Design

Peptide Vaccine Design

Due to the high conservation of the backbone region of HA2, it represents an excellent target.Hepatitis VirusesInfection with hepatitis C virus (HCV) can lead to liver diseases such as cirrhosis or hepatocellular carcinoma. The development of effective HCV vaccines has been hindered by the variability of sequences within T cell-targeted epitopes. ...

ByCreative Peptides


Unveiling the Role of CD73: A Key Player in Immune Regulation and Beyon

Unveiling the Role of CD73: A Key Player in Immune Regulation and Beyon

Aberrantly glycosylated CD73 and a human-specific CD73 isoform (CD73s)[22] have been identified in human hepatocellular carcinoma (HCC), leading to the functional suppression of tumor CD73. Additionally, CD73 expression was found to be downregulated in advanced-stage prostate, laryngeal, and high-grade colon carcinomas. Lower CD73 expression ...

ByBeta Lifescience


Protein Quantification Techniques and Their Application in Clinical Research

Protein Quantification Techniques and Their Application in Clinical Research

Moreover, LFQ is commonly used in biomarker detection of other diseases and tumors, such as Vps35 for Parkinson's disease, SOAT1 for hepatocellular carcinoma, GOT2 for prostate cancer, A1AT for bladder cancer. ...

ByCreative Proteomics


Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Subjects who met any of the following criteria were excluded: (1) hepatitis B or C virus infection; (2) autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis; (3) gastrointestinal cancers or hepatocellular carcinoma; (4) drug-induced steatosis or liver injury; (5) Wilson disease or hemochromatosis; (6) excessive alcohol consumption ...

ByKoBioLabs


Degradation of splicing factor SRSF3 contributes to progressive liver disease

Degradation of splicing factor SRSF3 contributes to progressive liver disease

As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRSF3 is decreased in human liver samples with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), or cirrhosis that was associated with alterations in RNA splicing of known SRSF3 ...

ByJohnson Controls, Inc.


Expanded and Activated Natural Killer Cells for Immunotherapy of Hepatocellular Carcinoma

Expanded and Activated Natural Killer Cells for Immunotherapy of Hepatocellular Carcinoma

Abstract Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a therapeutic role for NK-cell infusions in HCC. ...

ByNkarta, Inc.


Labelling of albumin microspheres with 188Re: a possible agent for radiotherapy

Labelling of albumin microspheres with 188Re: a possible agent for radiotherapy

Labelled microspheres were found to be stable in vitro; 43 h after labelling, 87% of 188Re was bound to the microspheres.Keywords: albumin microspheres, labelling methods, 188Re, radiotherapy, endoradiotherapy, tumours, radiolabelling, beta emitters, hepatocellular ...

ByInderscience Publishers

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