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Histopathological Articles & Analysis
23 articles found
Furthermore, the integration of artificial intelligence and machine learning into histopathology is still a work in progress, necessitating rigorous validation to ensure reliability. ...
Posterolateral Rabbit Spinal Fusion Study I. Introduction Autologous bone has long been the gold standard for bone graft substitute in spinal fusion procedures. The limited supply and morbidity associated with using autologous graft material led to the development of alternative bone grafting materials. Bioactive glass has a long history of biomedical use and has been shown to facilitate mineral ...
The test sample is graded by comparing the difference in the degree of tissue reaction (histopathology) between the test sample and the negative control. Systemic toxicityWe conduct tests on mice to detect medical devices that may produce systemic (but not local) toxic effects. ...
On the other hand, both linkers showed similar buffer stability, cathepsin B release efficiency, cellular activity, and histopathological characteristics. The tetrapeptide Gly-Gly-Phe-Gly exhibits all the properties of a stable and efficient cleavable linker used in the marketed ADC drug Enhertu. ...
The results, supported by light microscopy and histopathology evaluations, revealed that the exposure to the mixture of NNK and BaP triggered the occurrence of lung cancer. ...
The aim of the project was to develop a Polish complementary system of molecular surgical navigation for the treatment of ...
In 2016, they served a population of circa one million inhabitants and were processing about 64,000 histopathology specimens per year with just 23 pathologists, leaving them struggling with many of the same problems that persist for labs all over the world today. ...
Since the 19th century, the practice of tissue processing has remained largely unchanged, resulting in solidified, paraffin-embedded tissue blocks for sectioning. As staining procedures have advanced and immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurate interpretation of disease ...
These results suggest that bacteriocins can exert multiple positive responses in the host, such as altered immunogenic responses, altered inflammatory responses, and reduced infection-related biochemical and histopathological parameters. On the other hand, 20% of studies conducted in surrogate models assessed antibacterial activity but did not report toxicity. ...
The digital pathology software company PathPresenter (Montville, New Jersey) and the precision oncology platform firm 4D Path have entered into a partnership that could improve the diagnostic accuracy of breast tumor profiling. PathPresenter has developed a digital workflow tool for clinicians, pathologists and pharma companies to aggregate medical data. ...
In a rat renal I/R injury model, Gal-3 levels, renal function, and histopathology were evaluated in rats pretreated with P-MCP for one week (n = 16) compared to controls (n = 16). ...
Formalin-fixed lung samples were subject to histopathology and immunohistochemistry (IHC) examinations. Results Feed homogenates from theTreatment I (NC) remained PRRSV PCR negative throughout the 0-21 d in vitro experiment. ...
Following BTLT implantation on the surface of the liver in mice expressing the mutant human form of alpha-1 antitrypsin (PiZ mouse), human albumin, transferrin, alpha-1 antitrypsin (AAT) and fibrinogen were detected in the circulation as early as 7 days, with increasing levels of human albumin detected for at least 90 days post-implantation. Histopathologic evaluation of ...
Methods: Two cohorts, consisting of men with histopathologically negative index biopsies, followed by a positive or negative repeat biopsy, were combined. ...
Adult female mink and a subsequent F1 generation were exposed to Aroclor 1268 through diet, and effects on enzyme induction, histopathology, thyroid hormone regulation, hematology, organ weights, and body condition index were compared to a negative control and a 3,3',4,4',5‐pentachlorobiphenyl (PCB 126) positive control. ...
Gill ventilation rate, a measure of oxidative stress, did not change in contrast to other studies finding enhanced osmoregulatory disturbance and gill histopathology following atrazine exposure. To more closely reflect field conditions, we recommend that laboratory studies should focus more on examining the effects of commercial pesticide formulations which contain additional ...
Histopathological assessments of fish from aquatic ecotoxicology studies are being performed with increasing frequency. Aquatic ecotoxicology studies performed for submission to regulatory agencies are usually conducted with multiple subjects (e.g., fish) in each of multiple vessels (replicates) within a water control and within each of several concentrations of a test ...
Chronic administration to Wistar rats of Mild Silver Protein (MSP) to a dose of 222 mg Ag/kg/day in the drinking water for six months showed that the MSP produces argyria, with histopathological lesions in the kidney, the organ where silver accumulates. The histopathology of the kidney showed capillary damage, with alteration of the vascular wall, increased ...
Bisphenol A (BPA) is an intermediate used to produce epoxy resins and polycarbonate plastics. Although BPA degrades rapidly in the environment with aquatic half‐lives from 0.5 to 6 d, it can be found in aquatic systems from widespread use. To evaluate potential effects from chronic exposure, fathead minnows were exposed for 164 d to nominal concentrations of 1, 16, 64, 160, and 640 µg/L BPA. ...
Activity of hepatic CYP1A enzymes in adult and juvenile mink exposed to TCDD, PeCDF, or TCDD was generally greater compared with controls, but changes in other CYP1A endpoints were less consistent. Histopathology of the mandible and maxilla of juvenile mink suggested a dose‐related increase in the incidence of jaw lesions. ...