hormone level Articles
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What’s Safe in Your Medicine Cabinet: Dietary Supplements in the U.S.
Abstract: What's Safe in Your Medicine Cabinet: Dietary Supplements in the U.S. From regulating hormone levels to supplementing nutritional deficiencies in children, dietary supplements have a broad spectrum of needs to cater to. Popping a vitamin pill or biting down on an energy bar is not as simple as it once was though. The plethora of products available to supplement your diet are so ...
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Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish
Pentachlorophenol (PCP) is frequently detected in the aquatic environment and has been implicated as an endocrine disruptor in fish. In the present study, 4‐month‐old zebrafish (Danio rerio) were exposed to 1 of 4 concentrations of PCP (0.1, 1, 9, and 27 µg/L) for 70 d. The effects of PCP exposure on plasma thyroid hormone levels, and the expression levels of selected genes, were measured in ...
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The endocrine effects of dietary BDE‐47 exposure, measured across multiple levels of biological organization, in breeding fathead minnows
The goal of the present study was to evaluate the reproductive function of fathead minnows (Pimephales promelas) exposed to brominated diphenyl ether 47 (BDE‐47) at doses lower than used in previous studies. This was accomplished by evaluating the impacts of BDE‐47 exposures across multiple levels of biological organization. Breeding pairs were exposed to BDE‐47 via diet for 21 days during ...
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Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine‐related genes in vitro and in vivo
Perfluorooctane sulfonate (PFOS) is a widespread and persistent chemical in the environment. We investigated the endocrine‐disrupting effects of PFOS using a combination of in vitro and in vivo assays. Reporter gene assays were used to detect receptor‐mediated (anti‐)estrogenic, (anti‐)androgenic, and (anti‐)thyroid hormone activities. The effect of PFOS on steroidogenesis was assessed both at ...
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A three‐generational study of in ovo exposure to PBDE‐99 in the zebra finch
Based on a literature review of avian data for polybrominated diphenyl ethers (PBDEs), ecologically relevant doses, low (10 ng/egg), medium (100 ng/egg), and high (1,000 ng/egg) of the 2,2',4,4',5‐pentabromodiphenyl ether (BDE‐99) congener along with dimethylsulfoxide (DMSO) control were injected into the yolk sac of un‐incubated eggs of zebra finch, Taeniopygia guttata. Offspring development ...
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Endocrine disruption by di‐(2‐ethylhexyl)‐phthalate (DEHP) in Chinese rare minnow (Gobiocypris rarus)
Great concern has been raised over the potential impact of environmental contaminants on fish populations that inhabit in the Three Gorge Reservoir (TGR). In the present study, we investigated the endocrine disrupting effects of di‐(2‐ethylhexyl)‐phthalate (DEHP), on the Chinese rare minnow (Gobiocypris rarus), an endemic fish distributing upstream waters in the Yangtze River. Adult rare ...
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Seasonal and sex-related variations in serum steroid hormone levels in wild and farmed brown trout
Salmo trutta L. in the north-west of SpainSerum steroid profiles were investigated in order to evaluate the potential use of circulating sex steroid levels as a tool for sex identification in brown trout. Changes in the serum concentrations of testosterone (T), progesterone (P), 17-β-estradiol (E2), and cortisol (F) in wild and farmed mature female and male brown trout, Salmo trutta L., were measured in each season (January, ...
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Bisphenol S alters embryonic viability, development, gallbladder size, and mRNA expression in chicken embryos exposed via egg injection
Amid concerns about the toxicological effects and environmental prevalence of bisphenol A (BPA), efforts to find suitable, safer replacement alternatives are essential. Bisphenol S (BPS) is one potential chemical substitute for BPA; however, few studies are available confirming it has a more desirable ecotoxicological profile. In the present study, BPS was injected into the air cell of ...
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Effects of progesterone and norethindrone on female fathead minnow (Pimephales promelas) steroidogenesis
As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (norethindrone, 168 ± 7.5 ng/L) and endogenous progestogen (progesterone, 34 ± 4.1 ng/L) on steroidogenesis in adult female fathead minnows ...
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Rani Therapeutics prices $73M IPO for robotic drug-delivery pill tech
Rani Therapeutics Holdings (NSDQ:RANI), developer of a robotic drug-delivery pill system, generated $73.3 million in its underwritten initial public offering (IPO) of Class A common stock. The San Jose, Calif.–based company’s IPO of 6.7 million shares priced at $11 a share, generating gross proceeds of $73.3 million. The company initially targeted an IPO worth approximately $100 ...
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How Sleep Deprivation Can Lead to Weight Gain
Sleep is an important factor to help maintain health and well-being. It’s recommended that an adult should get at least 7 hours of sleep a night. Getting a good night’s sleep has many benefits such as better memory, reduced stress levels and lowers the risk of heart disease. On the flip side, not getting enough sleep regularly can have serious repercussions such as a weaker immune ...
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Detailed Introduction to Steroids Analysis
Steroid hormone is a class of compounds that contain cyclopentane polyhydrophenanthrene structure formed by cholesterol and catalyzed by cytochrome P450 enzymes. Steroid hormones mainly include adrenocorticotropic hormones secreted by the adrenal cortex and sex hormones secreted by the gonads, which are mainly divided into four categories: progesterone, corticosteroid, estrogen and androgen. ...
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Assessment of multiple hormonal activities in wastewater at different stages of treatment
Changes in the endocrine potency of municipal wastewater at 3 wastewater treatment plants (WWTPs) in Australia were investigated using a panel of in vitro receptor‐driven transactivation assays. The assays were based on human estrogen receptor α, androgen receptor, progesterone receptor, glucocorticoid receptor, and peroxisome proliferator‐activated receptor γ2. Total removal efficiencies for ...
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Rani developing technology for oral delivery of injectable biologics
(NASDAQ:RANI) is developing a disruptive technology to solve the problem of converting biologic injectable drugs, including antibodies, peptides and proteins, into oral therapies with its RaniPill that bypasses destruction in the stomach to deliver its payload to the vascular intestinal wall in the GI tract. “This is not a new idea, although previous attempts were based on chemistry and ...
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