human papillomavirus Articles
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NFX1 interacts with msin3a/histone deacetylase to repress htert transcription in keratinocytes
Transcription of the catalytic subunit of telomerase (hTERT) in keratinocytes can be induced by human papillomavirus type 16 (HPV16) E6/E6AP ubiquitin ligase through degradation of the repressor, NFX1-91. Here, we demonstrate that NFX1-91 interacts with the corepressor complex mSin3A/histone deacetylase (HDAC) at the hTERT promoter. By degrading NFX1-91, E6/E6AP changes the chromatin structure at ...
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Addressing the cervical cancer burden in developing countries: Vietnam as a case study
Like most global diseases, the burden of the cervical cancer is borne primarily by women in less developed nations. In Vietnam, the government and certain private players are attempting to address the high mortality and morbidity rates of the disease. Vietnam promises to be an example of a relatively effective government approach for tackling cervical cancer that other similarly situated nations ...
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HPV-16 E7-Specific Cellular Immune Response
HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study High-risk human papillomavirus (HPV) infection is the cause of almost all cervical cancers. HPV16 is one of the main risk subtypes. Although screening programs have greatly reduced the prevalence of cervical cancer in ...
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A Bayesian design for phase I cancer therapeutic vaccine trials
Abstract Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage. However, these designs are poorly applicable for the development of cancer therapeutic vaccines because the expected safety concerns for these vaccines are not ...
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CD Genomics Perspective: Introduction to Virus Identification Using RNA Sequencing
RNA sequencing (RNA-Seq) is a high-throughput RNA profiling technique that uses next-generation sequencing (NGS) platforms, and offers accurate abundance estimations over a wide dynamic range. Both high and low expression levels in individual viral RNA sequencing experiments can be determined using a wide dynamic range, which greatly improves analysis efficiency. As a result, RNA-seq has played ...
By CD Genomics
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Overview of Microbial Epigenetics
Introduction to Microbial Epigenetics Epigenetics has been defined as the study of stable alterations in gene expression potentials that arise during development and cell proliferation, or alterations in DNA function without alterations in DNA sequence. Modern epigenetic features refer to the alteration of DNA and/or associated proteins without nucleotide sequence variance, which transmits the ...
By CD Genomics
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Legal Lookout: HPV Challenge Program: EPA Goes After Orphan
EPA recently posted on its Chemical Right-to-Know website a new policy, entitled Policy Regarding Acceptance of New Commitments to the High Production Volume (HPV) Challenge Program, available at www.epa.gov/chemrtk/hpvpolcy.pdf. The policy outlines how companies can commit to sponsor any of the remaining so-called “orphan chemicals,” which include the 300 chemicals that are currently ...
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How does your Vaginal Microbiome Affect your Cancer Risk?
When you hear about the vaginal microbiome (VMB), your first thought may be the role it plays in stuff like yeast infections or bacterial vaginosis (BV). But with improved research, we’re uncovering more of the VMB’s long-term effects, like its role in a healthy pregnancy and delivery. The complex community of organisms living in your vagina even plays a part in your risk of ...
By Juno Bio
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Preventive cancer vaccine based on neoantigens gets put to the test
Studying the vaccine in dogs could provide insight into its effectiveness in people What if someone told you that a vaccine shot could prevent you from getting multiple types of cancer—ones as different from each other as breast cancer and lymphoma? Stephen A. Johnston, cofounder of the health-care start-up Calviri and a scientist at Arizona State University’s Biodesign Institute, ...
By Calviri
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Myths vs Facts: HPV and Cervical Cancer
Cervical cancer is the second most common cancer affecting and causing deaths among women in India. Cervical cancer is caused by the Human Papilloma Virus or HPV. The lower part of the uterus known as Cervix is affected due to HPV infection. This cancer develops very slowly and most of the times is asymptomatic during the development stage. HPV infection is a sexually transmitted infection (STI) ...
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Sexually Transmitted Infections and Disease: The Silent Pandemic
Twenty-five years ago, the Institute of Medicine (IOM) published a report on confronting sexually transmitted diseases (STDs) as the “hidden epidemic of tremendous health and economic consequence in the United States, and that the scope, impact, and consequences of STDs are under recognized by the public and in healthcare.”1 Today, the United States is in the midst of a major ...
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