immune development Articles
-
Immunity development following oral vaccination against Actinobacillus pleuropneumoniae in a mouse model
Porcine contagious pleuropneumonia caused by Actinobacillus pleuropneumoniae (Ap) is a deadly disease in pigs. In this work, we attempt to determine immunogenic properties of an oral Ap vaccine in a mouse model. Formalin-inactivated, whole-cell Ap suspension is included in two vaccine formulations: the classic injectable form with aluminium adjuvant and the oral form encapsulated into ...
-
Possible role of molecular mimicry in pathogenesis of Ebola virus: implications for a rational vaccine design
Ebola Virus (EBOV) presents a challenge for vaccine development because immune correlates of protection in humans are not well known. In earlier studies we developed a concept of local similarity which refers to resemblance of structural patterns of unrelated proteins as a function of their amino acid composition. The search for local similarities between human and EBOV proteins was performed. ...
-
Breaking the Mould: Building a Research-Based Biotech Company in Australia from Scratch
Australia is a very challenging environment for early-stage biotechnology companies. Risk capital is hard to find, and investors are wary of over-promising and under-delivering start-ups, that commonly go aground because of limited resources pitched against the costly demands and long timeframes of drug development. For public companies, there is often a disconnect between the stock market ...
-
Education’s Role in Fighting Infectious Diseases
Misinformation can have a profound impact on public health, experts say that education might be the key to combating it. According to the World Health Organization (WHO), immunization saves millions of lives each year. But given that many are still hesitant to get vaccinated for COVID-19, it is apparent that we are amidst an ‘infodemic’. “We’re not just battling ...
-
Introduction to Protein N-glycosylation
Glycosylation is one of the most important protein post-translational modifications in organisms, occurring in 50%-70% of proteins in cells. It is associated with many diseases as it can affect essential life activities, such as cell recognition, differentiation, adhesion, signal transduction, and immune response. Immune diseases, congenital sugar defects, and dozens of genetic diseases, as well ...
-
Runny or stuffy nose in children. What to do?
Just stay calm! We’re here to help you. A stuffy or runny nose is a struggle for the child, and as a result, for the whole family, but it should not be dangerous if you know how to treat it properly. In this article, you will learn what causes a runny/stuffy nose in a baby or infant, and how to relieve the symptoms. Why does a runny/stuffy nose occur? A runny or blocked nose is caused ...
By Nosiboo
-
Flu shots urged as Madison’s FluGen plays role in effort for universal vaccine
David Wahlberg, Wisconsin State Journal October 18, 2018 With flu season approaching, health officials say people should get flu shots by the end of October, yet acknowledge that the annual vaccine generally works less than 60 percent of the time. The Madison company FluGen is part of a renewed national effort to improve the odds by developing a universal flu vaccine, which would protect ...
By FluGen, Inc.
-
CD Genomics Supports Immune and Cancer Research with TCR-Seq Service
CD Genomics is a world-leading genomics services company that continues to innovate in high throughput sequencing services for the genomics industry, as well as genotyping, bioinformatics, microarrays, and more. The company has recently launched TCR-seq, a powerful service that enables rapid and efficient analysis of T-cell receptor (TCR) diversity and clonality, providing critical support for ...
By CD Genomics
-
Introduction to AAV as a Gene Therapy Vector, Part 2
What are AAVs? and what makes them good candidates for gene therapy? Introduction In the first part of our three part series introducing AAV as a gene therapy vector, we talked about basic AAV vector biology. In this post, we’re going to take a step back to answer the question of “Why AAV?” and look at some opportunities in the AAV engineering space. Why AAV? Viral vectors ...
-
Don`t Throw Away Your Shot...the Cold Truth About Vaccine Handling and Storage
Overview In modern times, vaccines have been widely used to keep people healthy by protecting them from serious illnesses and diseases. Worldwide, vaccines annually prevent millions of deaths, and their utilization is responsible, in many parts of the globe, for the nearly total eradication of numerous diseases, including polio, measles, and smallpox. According to the U.S. Centers for Disease ...
-
Antigenic variation in plasmodium falciparum: gene organization and regulation of the var multigene family
Plasmodium falciparum imposes an enormous burden upon the developing world, with 300 to 500 million cases and 1 to 2 million deaths per year (94). Despite extensive esearch efforts, development of parasite drug resistance is a growing problem, and an ffective vaccine is still lacking. Individuals living in areas of high P. falciparum ransmission acquire protective immunity to severe ...
-
Developing Plasmodium falciparum malaria vaccines for populations living in areas with stable parasite transmission
Individuals living in areas with stable transmission of Plasmodium falciparum parasites develop substantial protective immunity to the disease during childhood. Because of naturally acquired immunity, which appears mainly to target parasite-encoded Variable Surface Antigens (VSA) on the Infected Erythrocytes (IE), severe and life-threatening disease among adults in such areas is rare. However, ...
-
CADM: A New Generation of Tumor Suppressor Genes
About Tumor Suppressor Genes A tumor suppressor gene, also known as anti-onco gene, is an essential component of the body's defense against cancer. It usually facilitates apoptosis. With its absence, the human body will be functioning without its “brake” of cell proliferation. Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. Here are some key ...
-
Brushing Your Allergies Away
Derek Lacarrubba was allergic to New York City. Lacarrubba, 31, got stuffed up around cats, dogs, three kinds of dust mites and several varieties of native New Yorkers - trees, that is. He couldn't sleep. He had trouble going to the gym. And as an attorney, he was too busy to commit to the years-long treatments doctors typically recommend: weekly shots at the doctor's office or holding liquid ...
-
Cytokine Involvement in Inflammatory Immune Disorders
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
-
Understanding the Benefits of Probiotic Formula for Gut Health
The gut microbiota, a diverse community of microorganisms residing in our gastrointestinal tract, plays a crucial role in maintaining our overall health. Probiotics, live microorganisms with potential health benefits, have garnered significant attention for their ability to promote gut health. In this article, we will delve into the science behind probiotic formulas, exploring their mechanisms of ...
-
What Are the Cytokines?
Cytokines are a class of small molecule proteins secreted by cells that mediate and regulate immune processes, and they act in an autocrine, paracrine and endocrine manner. More than 200 types of human cytokines have been identified, which can be generally classified into interleukins, interferons, tumor necrosis factors, colony-stimulating factors, chemokines, growth factors, etc. according to ...
-
The Importance of Vaccine Research and Quality Control
The controversy over vaccines and immunizations have become one of the most heavily debated topics. Vaccines have had the ability to save countless individuals from unnecessary illness, death, and have even helped to eliminate certain diseases. Over the last eight months, COVID-19 has created a global pandemic, to which there is currently no cure. As the virus continues to claim lives worldwide, ...
-
Oxygen therapy for rheumatology
HBOT is a very effective adjunctive treatment for Rheumatoid Arthritis procedures Rheumatoid arthritis is a chronic inflammatory autoimmune disorder that can affect the lining of the joints and cause painful swelling that will result in the erosion of bones and the deformation of joints, which aggravated, leads to physical disabilities. As an autoimmune disorder, rheumatoid arthritis ...
-
The Health Effects of Probiotics on the Human Body
Probiotics are a type of active microorganisms that play a role by improving the balance of the host's intestinal microflora. They can produce definite health effects to improve the host's microecological balance and play a beneficial role. In 2001, the World Food and Agriculture Organization (FAO) and the World Health Organization (WHO) also defined probiotics as follows: Live bacteria that can ...
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you