immune related Articles
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Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. ...
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ELISpot for measuring human immune responses to vaccines
The enzyme-linked immunosorbent spot (ELISpot) assay is one of the most commonly used methods to measure antigen-specific T cells in both mice and humans. Some of the primary reasons for the popularity of the method are that ELISpot is highly quantitative, can measure a broad range of magnitudes of response and is capable of assessing critical cellular immune-related activities such as IFN-g ...
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The power of autoantibodies as biomarkers of the immune response to cancer
How autoantibody profiling can further unlock the success of CPI therapy Immunotherapy has revolutionised the treatment of cancers, improving the prognosis for a variety of malignancies. One of the key elements in the immunotherapy war chest are checkpoint inhibitors (CPIs) which have been the main drivers behind this progress. These pioneering drugs, however, are not perfect, with a ...
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THE IMPACT OF ENDOCRINE‐DISRUPTING CHEMICALS ON OXIDATIVE STRESS AND INNATE IMMUNE RESPONSE IN ZEBRAFISH EMBRYOS
Bisphenol A (BPA) and nonylphenol (NP) are well‐known endocrine‐disrupting chemicals (EDCs) ubiquitous in the aquatic environment, and present an ecotoxicological risk for the health of aquatic organisms. Limited attention has been given to the immunotoxicity of these chemicals. The present study revealed a concentration‐dependent increase of reactive oxygen species content and an induced ...
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Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in mice
Abstract Gut microbiota play a major role in host physiology and immunity. Inflammatory bowel diseases (IBDs), the important immune-related diseases, can occur through immune system malfunction originating due to dysregulation of the gut microbiota. The aim of this study was to investigate the capabilities and mechanisms of Lactobacillus acidophilus (L. acidophilus) KBL402 and KBL409 treatment ...
By KoBioLabs
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Researchers Prepared New Tools for the Production of Exosome Drug Carriers
Recently, Yang Hui, a researcher at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, developed a nanofluidic chip technology to achieve high-throughput preparation of exosome drug carriers and experimentally verify the anti-tumor effect of novel exosome drug carriers. Exosomes are nanoscale particles that can be secreted into the extracellular space or body fluids by ...
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Long Read Sequencing Helps HLA Typing
HLA, human leukocyte surface antigen, a series of tightly interlocking motifs on the short arm of human chromosome 6, is the central basis for the immune system to recognize and differentiate between allogeneic substances. It is highly polymorphic and corresponds to a complex acquired immune system. It is importantly associated with a variety of autoimmune diseases, tumors, and infectious ...
By CD Genomics
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Antioxidant therapy and its stability on Chernobyl clean-up workers
This paper describes the effects of prolonged antioxidant therapy, its stability and association with spectral parameters of the fluorescent probe ABM in blood plasma and indices of albumin auto-fluorescence in Chernobyl clean-up workers from Latvia. Patients were divided into two groups. Group 1 received placebos of identical appearance to antioxidants. Group 2 received antioxidants (vitamin E + ...
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Novel Biomarkers May Help Predict the Susceptibility of a Population to Rheumatoid Arthritis
Genetics (i.e., mutations) are considered to be the main factor predisposing to the etiology of rheumatoid arthritis (RA), but they account for only a few changes in RA disease risk, and in contrast to genetics, the environment may have an important impact on epigenetic properties associated with disease etiology. Recently, in a study published in the journal Scientific Reports entitled ...
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Cytokine Involvement in Inflammatory Immune Disorders
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
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Cytokine Storms and Viral Infections
Cytokines are small soluble proteins that are secreted by immune cells and tissue cells to play a regulatory role between cells, including interferon (IFN), interleukin (IL), chemokines, colony-stimulating factors (CSF), tumor necrosis factors (TNF) and so on. Cytokines function in autocrine, paracrine or endocrine forms, and can regulate cell growth and differentiation, modulate immune response ...
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B7-H3: Broad Prospects of Emerging Tumor Immunotherapy Targets
Recently, in the renowned academic journal Nature Medicine, the Kimmel Cancer Center at Johns Hopkins University published Phase 2 clinical results regarding enoblituzumab, a monoclonal antibody targeting B7-H3, for the treatment of prostate cancer. The results demonstrate that enoblituzumab can successfully induce the body's anti-cancer activity, showing favorable therapeutic efficacy and safety ...
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The Role of Exosome RNA in Cancer
The Relationship Between Exosomes and Cancer Exosomes are nanoscale vesicles derived from intracellular lysosomes that shuttle a variety of biomolecules, such as nucleic acids, proteins, lipids, amino acids and metabolites, and play a key role in regulating intercellular communication. Exosomes can be secreted by almost all types of cells, including immune cells, blood cells, neuronal cells, ...
By CD Genomics
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12 Functional Food & Beverage Trends
Research and market data illustrate a confluence of consumer desires for functional foods and beverages, fueled by science demonstrating benefits of health-promoting ingredients. Take drinks alone. Ohad Cohen, Chief Executive Officer, Gadot Biochemical Industries, points to data from Grand View Research: The global functional drinks market size was estimated to be worth $204.8 billion in 2022, ...
By Nuritas Ltd.
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Remote Oncology Care: Review of Current Technology and Future Directions
Abstract Cancer patients frequently develop tumor and treatment-related complications, leading to diminished quality of life, shortened survival, and overutilization of emergency department and hospital services. Outpatient oncology treatment has potential to leave cancer patients unmonitored for long periods while at risk of clinical deterioration which has been exaggerated during the COVID19 ...
By Oncodisc
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Point of care pulmonary function testing: Important now, more than ever
As the relentless waves of the COVID-19 pandemic continue to wash over the world, much attention has been focused on the idea of hospital bed shortages. As cases strain hospital systems everywhere, the most-commonly reported metrics one hears have to do with beds; how many ICU beds left, how many emergency beds, how many beds overall. While it is of course critical to understand how much physical ...
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Cell Transplantation Promising for Treatment of Biliary Diseases
Biliary disease is a term used to describe diseases that affect the biliary system, which can result in inflammation, fibrosis, bile duct destruction, and eventually liver failure. It also frequently leads to secondary infections and chronic irritation, such as bile duct stones, which can lead to malignant tumors. There is currently no cure for biliary tract diseases other than liver ...
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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using Lactobacillus paracaseiKBL382 isolated from the feces of healthy Koreans. Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 109 CFU ...
By KoBioLabs
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Spatial profiling of chromatin accessibility in mouse and human tissues
Abstract Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1. The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping2,3,4,5, but the ability to capture spatial epigenetic information of tissue at the cellular level and genome scale is lacking. Here we ...
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