Immune Response Profiles Articles & Analysis
4 articles found
COVID-19 shares similarities with other respiratory infections, yet we still have a limited understanding of the immune response to SARS-CoV-2. To better understand the immune landscape of patients with severe COVID-19, a study led by Drs. Vick, Frutoso, Prlic, and Lund characterized the immune profile of ...
Bacteriocins are small, thermostable, ribosomally synthesized antimicrobial peptides produced by bacteria that are active against other bacteria and to which the producer is immune. They exhibit considerable diversity in size, structure, mechanism of action, inhibitory profile, immune mechanism, and target cell receptors. ...
However, they tend to trigger strong immune responses in humans, which limits their applicability for gene therapy applications, particularly in immunocompromised patients [1]. Compared to adenovirus and lentivirus, AAV offers a low immune profile, relative safety, long-lasting expression in non-dividing cells, and a long ...
The challenges of evading both pre-existing immunity and de novo adaptive immune responses against AAV vectors are made especially difficult by the heterogeneous nature of patient immune responses and immune histories. ...