immune suppression Articles
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The enhancement of Th1 immunity and the suppression of tumour growth by low-dose γ-radiation
To address if the modulation of immunity balance by low dose radiation is involved in the enhancement of the anti-tumour function, we examined the effect of 0.5 Gy γ-irradiation on the Th1/Th2 immunity balance in Ehrlich Solid Tumour (EST)-bearing mice. Repeated 0.5 Gy γ-irradiation significantly delayed the growth of tumours. The cytotoxic activities of Natural Killer (NK) cells and Cytotoxic T ...
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New and dangerous mold
Cryptococcus gattii was considered to be a mold found only in semi tropical and topical climates until it was found recently in the Pacific Northwest. It seems to have adapted to the cool, wet environment on Vancouver Island, Canada and spread from there to western Canada, Washington (state) and Oregon. It may have already spread to Idaho and California. Normally, Cryptococcus molds are capable ...
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Ozette’s computationally-driven analysis aids advancement of cancer drug development - Case study
Summary Inflammation is a hallmark of the tumor microenvironment and an area of active investigation. To better understand how tumor inflammation differs from general inflammation, such as in gum disease, Drs. Prilic, Mair, and Erikson employed novel methods, which included high parameter flow cytometry and Ozette’s foundational technology–full annotation using ...
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Your Herd Vaccinations May not Always be Successful? Why?
We hear a lot about how to protect yourself and others right now… and it is especially important to me because I am in a high-risk group (over 65 with underlining health conditions). In the Dairy Industry, we deal with high-risk groups every day–cows that have just calved and newborn calves less than 75 days of age. Herd immunity threshold (percent of animals that are immune) ...
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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using Lactobacillus paracaseiKBL382 isolated from the feces of healthy Koreans. Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 109 CFU ...
By KoBioLabs
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Saving Us from Ourselves: Harnessing the Power of CAR-T to Combat Autoimmunity
What is autoimmune disease? Autoimmune disease a condition in which the body’s immune system mistakenly attacks the body itself. Thus far, more than 80 different autoimmune diseases have been identified, with some of the most prevalent including rheumatoid arthritis, Crohn’s disease, type 1 diabetes, and multiple sclerosis [1]. Autoimmune disease is one of the top ten causes of ...
By Indee Labs
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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Gamma delta T cells in tumor immunotherapy
Immunotherapy, in addition to surgery, chemotherapy, and radiotherapy, has now become the fourth pillar of anticancer treatment, with T cell-based immunotherapy being a successful cancer treatment technique. T cells can be separated into two subpopulations based on the expression of T-cell receptors (TCRs). αβ T cells, expressing expressing αβ TCR, recognize peptide antigens, such as those ...
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Unveiling the Role of CD73: A Key Player in Immune Regulation and Beyon
What is CD73? CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. However, this mechanism is often hijacked ...
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Proteins That Provide Key Information to Identify Patients with Poor Prognosis Found
In recent years, immune-based cancer treatment methods have given doctors and patients a lot of hope. Drugs called immune checkpoint inhibitors have provided life-saving benefits to more and more people suffering from melanoma, lung cancer, bladder cancer, and many other types of cancer. Although these drugs are exciting, a frustrating sticking point is that doctors cannot predict who will ...
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Antacids, Prescription Drugs or Digestive Enzymes? Your Best Bet for Better Digestion
Upset stomach, heartburn, diarrhea? There are few symptoms as disruptive to your daily life as ones that originate in the digestive system. And if you’re struggling with any of these symptoms, you know exactly how difficult they are to get rid of for good. Doctors recommend a variety of treatments, but there are three biggies they suggest most often for patients who are dealing with both ...
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The Health Effects of Probiotics on the Human Body
Probiotics are a type of active microorganisms that play a role by improving the balance of the host's intestinal microflora. They can produce definite health effects to improve the host's microecological balance and play a beneficial role. In 2001, the World Food and Agriculture Organization (FAO) and the World Health Organization (WHO) also defined probiotics as follows: Live bacteria that can ...
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Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis
Abstract Gut microbiota play an important role in immune responses and energy metabolism. In this study, we evaluated whether administration of Lactobacillus fermentum (L. fermentum) KBL375 isolated from healthy Korean feces improves the atopic dermatitis using the house dust mite (Dermatophagoides farinae)-induced atopic dermatitis (AD) mouse model. Administration of L. fermentum KBL375 ...
By KoBioLabs
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