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Immunoassays Articles & Analysis
19 articles found
Advantages of Colored Polystyrene Particles in Immunoassays Latex particles formed from amorphous polymer (usually polystyrene) represent a class of particles that have applications in many different aspects of biotechnology. These monodisperse particles range in size from 20 nm to 160 µm, with 100-400 nm covering the typical range used in lateral flow ...
High Specificity and Accuracy The assay employs a homogeneous immunoassay format, eliminating the need for washing steps that can introduce variability. ...
Diagnostic Tools In diagnostics, synthetic peptides serve as antigens in immunoassays and biosensors, helping to detect the presence of antibodies or pathogens in biological samples with high specificity and sensitivity. ...
Compared with ELISA and Western blotting, it offers higher specificity and coverage.Multiplex Immunoassay TechniquesFor example, using platforms based on multiple antibodies, multiple HCPs can be detected simultaneously.When conducting host cell protein (HCP) residual detection, it is essential to consider the specific host system used for the production of bioproducts, as ...
HCP detection and control requirements According to the International Conference on Harmonization (ICH) guideline Q6B, for host cell protein detection, a more sensitive method is usually required. For example, an immunoassay that can detect a variety of protein impurities. The polyclonal antibody (pAb) used in the test is produced by immunizing a production cell preparation ...
GlyFn, pregnancyassociated plasma protein-A2 (PAPPA2), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured by immunoassay. GlyFn was also determined using a rapid point-of care (POC) test format. ...
With the deepening of the research on the three-dimensional structure, binding characteristics and stability of biotin and avidin, the application of BAS and its related technologies in a variety of automated immunoassay techniques has further promoted the development of sensitive, rapid and accurate determination techniques for some trace substances in plasma and body fluids ...
The different microspheres bind proteins (antibodies or antigens for immunoassays) against different substances to be detected. The detection antibody is labeled with biotin and stained with a highly sensitive fluorescent dye. ...
BetaLifeScience provides high-quality MMP-3 antigens and antibodies that have been validated on LF (Lateral Flow) and CLIA (Chemiluminescent Immunoassay) platforms, contributing to the development of in vitro diagnostic test kits. ...
In addition, two types of ELISA immunoassays are used to quantitatively measure the ADC analytes: The first type measures total antibodies, namely ADCs with DAR greater than or equal to zero. ...
Our standard gold nanocages are citrate stabilized, and are suitable for applications such as targeting cancer cells, contrast enhancement agents, photothermal therapy, and biological immunoassay. Other ligands such as aromatics, carboxyls, amines are available upon request. ...
It is widely used not only in several biochemical assays but also in immunoassay (ELISA) kits. As a key component of the color development system of several kits, peroxidase has an important impact on the quality of the kits. ...
IL-6 is also associated with some autoimmune diseases, and IL-6 blockers are approved for the treatment of rheumatic diseases and other autoimmune diseases. Comprehensive immunoassays of matched samples of irEC tissue and normal tissue from patients treated with immune checkpoint blockade (12 in the observation group and 11 in the validation group) showed different immune ...
We maintain our commitment to their diagnosis, with kits for the in vitro diagnosis of the following rare diseases*: Rare Disease : Diagnostic tests Cystic fibrosis or fibrocystic disease of the pancreas : Determination of 50 cystic fibrosis mutations in patients and relatives by genetic analysis Multiple sclerosis : Determination of anti-ganglioside and anti-myelin-associated glycoprotein ...
Until now, diagnosis of HIT mainly involves the clinical probability evaluation, testing for presence of heparin-dependent antibodies (IgG isotype) with an immunoassay, and confirmation with a functional assay (rarely available on site). ...
Immunoassays for heparin dependent antibodies have been introduced since the discovery of PF4 as the major target antigen in presence of heparin. Different immunoassay presentations are available, and interestingly heparin can be replaced by polyanions complexes and its native structure is then altered as shown on figure 3. ...
Analysis supports validation and verification of factory cleaning and investigation of recalls and incidents. Immunoassay based food allergen detection methods rely on the use of antibodies to detect allergens present in food, it follows that such detection may be effected by processing. ...
Has LC-MS Become a Generally Accepted Tool for Complementing Immunoassay-based HCP Analysis? My colleague Catalin Doneanu and I just returned from Lisbon, Portugal, where we attended the BEBPA Conference on Host Cell Protein (HCP) analysis. Along with the other 120 attendees, we participated in open and thoughtful discussions on the best practices for HCP analysis using ...
Our vitamin D accuracy by mass spec is on the order of +/- 5%, as compared to +/-25% with immunoassays. We can identify the different forms of vitamin D, which is very important to be able to do, and we have reduced turnaround time significantly compared to what we had been doing. ...