In Vitro Models Articles & Analysis: Older
29 articles found
Cancer is a worldwide disease and one of the leading causes of morbidity and mortality today. Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation ...
Determine Cytotoxicity and EfficacyEvaluating the toxicity and killing effects of ADC on target cancer cells through in vitro and in vivo models is a key step in verifying its efficacy. These tests can help determine effective doses and potential side effects, thereby guiding the design of clinical trials.4. ...
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage. Benefits and advantages of iPSC differentiation to ...
Immunogenicity assessment involves a multifaceted approach, including in vitro studies, animal models, and clinical trials, to thoroughly evaluate the immunogenic potential of a candidate molecule. ...
The complexity and diversity of these conditions necessitate the development of detailed medical models for a comprehensive understanding of the diseases. Over time, Type 1 and Type 2 Diabetes Mellitus Models, Metabolic Disease Models, and generalized Diabetes Models have become integral to diabetes research and treatment ...
These models stem from animal models to in vitro and in silico models, each playing a unique role in observing the disease. ...
With the continuous development of various in vitro and electronic models, it is now possible to predict the immunogenicity of HCP impurities based on their amino acid sequences. However, these models have limited experience in clinical trials and their correlation with clinical outcomes has yet to be investigated in more depth, thus the ...
These models stem from animal models to in vitro and in silico models, each playing a unique role in observing the disease. ...
Organoids can be started from two main types of stem cells: (1) pluripotent embryonic stem (ES) cells or synthetically induced pluripotent stem (iPS) cells and (2) organ-restricted stem cells. In vitro models of SARS-CoV-2 infection are critical for understanding the host and viral factors that support cellular tropism and the viral replication cycle. ...
Contexte Myasthenia gravis (MG) is an autoimmune disease caused by the presence of antibodies directed against components of the muscle membrane located at the neuromuscular junction. In the majority of cases, these are autoantibodies directed against the acetylcholine receptor (AChR). The origin of the autoimmune response is not known, but thymic abnormalities and defective regulation of the ...
The addition of BOC amino acids to the environment leads to the synthesis of the Cas9 protein, which stimulates the activity of the gene editing system. Using in vitro cell culture models and transgenic mouse models, the researchers demonstrated that this novel CRISPR/Cas9 gene editing system exhibits gene editing activity only in the presence ...
The strategy to support "first-come" sequential combination therapy with anticancer targeted drugs is currently obtained in in vitro cell models and needs to be further validated in in vivo animal models. ...
We have demonstrated the suitability of this bone graft substitute both in in-vitro and in-vivo models. In the in-vitro model, rhBMP-2 release was sustained for 28 days. ...
Both current in vitro and in vivo models used in the development of candidate therapies for the treatment of intestinal diseases have severe limitations. ...
The selected 3D bioprinting approach offers an attractive tool for fabrication of 3D in-vitro human alveolar lung models. Discover more here : http://ijb.whioce.com/index.php/int-j-bioprinting/article/view/332 ABSTRACT The global prevalence of respiratory diseases caused by infectious pathogens has resulted in an increased demand for realistic ...
ByRegenhu
RepliGut® Advantages Altis Biosystems is developing in vitro human gut models for use in various applications. These RepliGut® models are derived from human donor stem cells. ...
Developing an Inflammatory RepliGut® Model There are currently no in vitro models that completely model inflammatory diseases of the intestine. ...
The liver plays an incredibly important role in the human body by metabolizing drugs and other compounds. Developing accurate in vitro liver models to study is a critical step in better understanding the biological dynamics of our bodies and removing our dependence on animal models. In their recent publication, Allevi authors Marie Cuvellier, ...
RepliGut® tissue constructs have been designed to meet this need. Lack of Robust in Vitro Gut Models Very few in vitro models available accurately represent the gut. ...
A recent study on FucoVital using an in vitro model of non-alcoholic fatty liver was conducted by Joseph Tarn, Ph.D., head of the Obesity and Metabolism Laboratory and director of the Multidisciplinary Center for Cannabinoid Research, Faculty of Medicine, at The Hebrew University of Jerusalem. ...
ByAlgatech