In Vivo Drug Articles & Analysis
9 articles found
In the realm of pharmacology and drug development, the assessment of drug permeability is essential. One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. ...
This article explores the diverse applications of copper-free click chemistry in biomedical research, highlighting its potential for clickable drug surrogates, labeling cellular membrane lipids and proteins, in vivo imaging, and in vivo drug delivery. ...
Radioactive drug conjugates (RDCs), as a particular form of coupling drugs, are formed by combining radioactive isotopes with disease-targeting molecules. ...
It is also increasingly applied in drug development. FC not only can detect intracellular and extracellular components, but also detect soluble analytes in serum or plasma samples, such as cytokines, drug complexes, or anti-drug antibodies (ADA). ...
Biological Analysis of ADC In order to characterize the PK characteristics of different ADC components, several analytical methods are required: (1) ELISA determines the kinetic curves of the conjugate and total antibody. (2) TFC-MS/MS can quantify the free drugs or metabolites. (3) High-resolution mass spectrometry for in vivo drug antibody ...
Advantages of Liposomes as Drug Delivery Vehicles l As drug delivery vehicles, liposomes have low toxicity and immunogenicity, and the high biocompatibility and biodegradability of their components—phospholipids can increase the in vivo drug concentrations and protect drugs from degradation. l They can be ...
These enzymes can activate, deactivate or reactivate drugs through structural changes in their composition. The direct effect of microorganisms on drug response is that the intestinal flora affects the bioavailability of a drug by altering its chemical structure. ...
Drug development platform, BIOiSIM™, was used to narrow down two different drug classes with distinct modes of action and modalities. ...
Nanoconjugates have matured from simple devices to multifunctional, biodegradable, non–toxic and non–immunogenic constructs, capable of delivering synergistically functioning drugs in vivo. The present study evaluates the efficacy of drug polymer self folding nano–conjugates of pectin–cisplatin to enhance blood circulating levels of cisplatin. ...